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PMID: 21741842 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

miRNA response to DNA damage.

Trends in biochemical sciences ·Vol. 36 ·No. 9 ·2011-09-00 ·Pages 478-84

Wan G, Mathur R, Hu X, Zhang X, Lu X

Abstract

Faithful transmission of genetic material in eukaryotic cells requires not only accurate DNA replication and chromosome distribution but also the ability to sense and repair spontaneous and induced DNA damage. To maintain genomic integrity, cells undergo a DNA damage response using a complex network of signaling pathways composed of coordinate sensors, transducers and effectors in cell cycle arrest, apoptosis and DNA repair. Emerging evidence has suggested that miRNAs play a crucial role in regulation of DNA damage response. In this review, we discuss the recent findings on how miRNAs interact with the canonical DNA damage response and how miRNA expression is regulated after DNA damage.

MeSH Terms
Apoptosis Cell Cycle Checkpoints Cell Transformation, Neoplastic/genetics,metabolism DNA Damage DNA Repair Gene Expression Regulation, Neoplastic Humans MicroRNAs/genetics,metabolism RNA Processing, Post-Transcriptional RNA Stability Signal Transduction Transcription Factors/genetics,metabolism Transcription, Genetic Transcriptional Activation Tumor Suppressor Protein p53/genetics,metabolism
Chemicals
MicroRNAs TP53 protein, human Transcription Factors Tumor Suppressor Protein p53
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Wan Guohui
Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Mathur Rohit
Hu Xiaoxiao
Zhang Xinna
Lu Xiongbin
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Article Info
Journal
Trends in biochemical sciences
Abbr.
Trends Biochem Sci
ISSN
0968-0004
DOI
10.1016/j.tibs.2011.06.002
Published
2011-09-00
Epub
2011-00-07
Pages
478-84
Language
English
Region
England
NLM ID
7610674
PMCID
PMC3532742
Subset
IM
Grants
NCI NIH HHS · R01 CA136549 · United States
NCI NIH HHS · R01 CA136549-03 · United States
NCI NIH HHS · CA136549 · United States
External Links
PubMed source DOI: 10.1016/j.tibs.2011.06.002 PMC Full Text View journal details
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