Home LiteratureArticle Details
PMID: 23109937 Published · epublish English Journal Article

Long non-coding RNAs in cancer progression.

Frontiers in genetics ·Vol. 3 ·2012-00-00 ·Pages 219

Tano K, Akimitsu N

Abstract

Recent large-scale transcriptome analyses have revealed that transcription is spread throughout the mammalian genomes, yielding large numbers of transcripts, including long non-coding RNAs (lncRNAs) with little or no protein-coding capacity. Dozens of lncRNAs have been identified as biologically significant. In many cases, lncRNAs act as key molecules in the regulation of processes such as chromatin remodeling, transcription, and post-transcriptional processing. Several lncRNAs (e.g., MALAT1, HOTAIR, and ANRIL) are associated with human diseases, including cancer. Those lncRNAs associated with cancer are often aberrantly expressed. Although the underlying molecular mechanisms by which lncRNAs regulate cancer development are unclear, recent studies have revealed that such aberrant expression of lncRNAs affects the progression of cancers. In this review, we highlight recent findings regarding the roles of lncRNAs in cancer biology.

Keywords
ANRIL HOTAIR MALAT1 cancer disease large non-coding RNA
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Tano Keiko
Radioisotope Center, The University of Tokyo Tokyo, Japan.
Akimitsu Nobuyoshi
References (49)
49 references, click to expand
  1. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project.
    Nature. 2007 Jun 14;447(7146):799-816 PMID: 17571346
  2. ncRNA- and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs.
    Cell. 2011 Nov 11;147(4):773-88 PMID: 22078878
  3. CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer.
    Nucleic Acids Res. 2010 Sep;38(16):5366-83 PMID: 20423907
  4. Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers.
    Cancer Res. 2011 Oct 15;71(20):6320-6 PMID: 21862635
  5. 3' end processing of a long nuclear-retained noncoding RNA yields a tRNA-like cytoplasmic RNA.
    Cell. 2008 Nov 28;135(5):919-32 PMID: 19041754
  6. A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains.
    BMC Genomics. 2007 Feb 01;8:39 PMID: 17270048
  7. Genome-wide association study identifies three loci associated with melanoma risk.
    Nat Genet. 2009 Aug;41(8):920-5 PMID: 19578364
  8. The long noncoding MALAT-1 RNA indicates a poor prognosis in non-small cell lung cancer and induces migration and tumor growth.
    J Thorac Oncol. 2011 Dec;6(12):1984-92 PMID: 22088988
  9. Long noncoding RNAs: functional surprises from the RNA world.
    Genes Dev. 2009 Jul 1;23(13):1494-504 PMID: 19571179
  10. MALAT-1 enhances cell motility of lung adenocarcinoma cells by influencing the expression of motility-related genes.
    FEBS Lett. 2010 Nov 19;584(22):4575-80 PMID: 20937273
  11. Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility.
    Nat Genet. 2009 Aug;41(8):905-8 PMID: 19578366
  12. Genome-wide determination of RNA stability reveals hundreds of short-lived noncoding transcripts in mammals.
    Genome Res. 2012 May;22(5):947-56 PMID: 22369889
  13. Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a.
    Mol Cell. 2010 Jun 11;38(5):662-74 PMID: 20541999
  14. An architectural role for a nuclear noncoding RNA: NEAT1 RNA is essential for the structure of paraspeckles.
    Mol Cell. 2009 Mar 27;33(6):717-26 PMID: 19217333
  15. Overexpression of the natural antisense hypoxia-inducible factor-1alpha transcript is associated with malignant pheochromocytoma/paraganglioma.
    Endocr Relat Cancer. 2011 Apr 28;18(3):323-31 PMID: 21422080
  16. Upregulated MALAT-1 contributes to bladder cancer cell migration by inducing epithelial-to-mesenchymal transition.
    Mol Biosyst. 2012 Sep;8(9):2289-94 PMID: 22722759
  17. INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosis.
    PLoS One. 2009;4(4):e5027 PMID: 19343170
  18. ANRIL, a long, noncoding RNA, is an unexpected major hotspot in GWAS.
    FASEB J. 2011 Feb;25(2):444-8 PMID: 20956613
  19. Long non-coding RNAs: insights into functions.
    Nat Rev Genet. 2009 Mar;10(3):155-9 PMID: 19188922
  20. Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk.
    PLoS Genet. 2010 Dec 02;6(12):e1001233 PMID: 21151960
  21. Small regulatory RNAs in mammals.
    Hum Mol Genet. 2005 Apr 15;14 Spec No 1:R121-32 PMID: 15809264
  22. Characterization of a germ-line deletion, including the entire INK4/ARF locus, in a melanoma-neural system tumor family: identification of ANRIL, an antisense noncoding RNA whose expression coclusters with ARF.
    Cancer Res. 2007 Apr 15;67(8):3963-9 PMID: 17440112
  23. Genome-wide association study identifies five susceptibility loci for glioma.
    Nat Genet. 2009 Aug;41(8):899-904 PMID: 19578367
  24. Genome-wide analysis of long noncoding RNA stability.
    Genome Res. 2012 May;22(5):885-98 PMID: 22406755
  25. Malat1 is not an essential component of nuclear speckles in mice.
    RNA. 2012 Aug;18(8):1487-99 PMID: 22718948
  26. Kcnq1ot1 antisense noncoding RNA mediates lineage-specific transcriptional silencing through chromatin-level regulation.
    Mol Cell. 2008 Oct 24;32(2):232-46 PMID: 18951091
  27. HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer.
    Oncogene. 2013 Mar 28;32(13):1616-25 PMID: 22614017
  28. Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs.
    Cell. 2007 Jun 29;129(7):1311-23 PMID: 17604720
  29. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis.
    Nature. 2010 Apr 15;464(7291):1071-6 PMID: 20393566
  30. Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation.
    Ann Surg Oncol. 2011 May;18(5):1243-50 PMID: 21327457
  31. A large noncoding RNA is a marker for murine hepatocellular carcinomas and a spectrum of human carcinomas.
    Oncogene. 2007 Feb 8;26(6):851-8 PMID: 16878148
  32. Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15(INK4B) tumor suppressor gene.
    Oncogene. 2011 Apr 21;30(16):1956-62 PMID: 21151178
  33. Identification of cis- and trans-acting factors involved in the localization of MALAT-1 noncoding RNA to nuclear speckles.
    RNA. 2012 Apr;18(4):738-51 PMID: 22355166
  34. New common variants affecting susceptibility to basal cell carcinoma.
    Nat Genet. 2009 Aug;41(8):909-14 PMID: 19578363
  35. Nuclear speckles: a model for nuclear organelles.
    Nat Rev Mol Cell Biol. 2003 Aug;4(8):605-12 PMID: 12923522
  36. Long noncoding RNA as modular scaffold of histone modification complexes.
    Science. 2010 Aug 6;329(5992):689-93 PMID: 20616235
  37. Upregulation of miR-196a and HOTAIR drive malignant character in gastrointestinal stromal tumors.
    Cancer Res. 2012 Mar 1;72(5):1126-36 PMID: 22258453
  38. The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation.
    Mol Cell. 2010 Sep 24;39(6):925-38 PMID: 20797886
  39. Relationship between CAD risk genotype in the chromosome 9p21 locus and gene expression. Identification of eight new ANRIL splice variants.
    PLoS One. 2009 Nov 02;4(11):e7677 PMID: 19888323
  40. Targeting nuclear RNA for in vivo correction of myotonic dystrophy.
    Nature. 2012 Aug 2;488(7409):111-5 PMID: 22859208
  41. Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all.
    Nat Rev Mol Cell Biol. 2006 Sep;7(9):667-77 PMID: 16921403
  42. Inhibition of metastasis-associated lung adenocarcinoma transcript 1 in CaSki human cervical cancer cells suppresses cell proliferation and invasion.
    Acta Biochim Biophys Sin (Shanghai). 2010 Mar 15;42(3):224-9 PMID: 20213048
  43. Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression.
    PLoS Genet. 2010 Apr 08;6(4):e1000899 PMID: 20386740
  44. Elevated expression of PCGEM1, a prostate-specific gene with cell growth-promoting function, is associated with high-risk prostate cancer patients.
    Oncogene. 2004 Jan 15;23(2):605-11 PMID: 14724589
  45. MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer.
    Oncogene. 2003 Sep 11;22(39):8031-41 PMID: 12970751
  46. MENepsilon/beta noncoding RNAs are essential for structural integrity of nuclear paraspeckles.
    Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2525-30 PMID: 19188602
  47. A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.
    Nat Genet. 2010 Jul;42(7):599-603 PMID: 20512145
  48. Establishment of histone h3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexes.
    Dev Cell. 2003 Apr;4(4):481-95 PMID: 12689588
  49. Genome-wide association study identifies five new breast cancer susceptibility loci.
    Nat Genet. 2010 Jun;42(6):504-7 PMID: 20453838
Article Info
Journal
Frontiers in genetics
Abbr.
Front Genet
ISSN
1664-8021
DOI
10.3389/fgene.2012.00219
Published
2012-00-00
Epub
2012-00-24
Pages
219
Language
English
Region
Switzerland
NLM ID
101560621
PMCID
PMC3479403
External Links
PubMed source DOI: 10.3389/fgene.2012.00219 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2