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PMID: 19578367 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Genome-wide association study identifies five susceptibility loci for glioma.

Nature genetics ·Vol. 41 ·No. 8 ·2009-08-00 ·Pages 899-904

Shete S, Hosking FJ, Robertson LB, Dobbins SE, Sanson M, Malmer B, Simon M, Marie Y, Boisselier B, Delattre JY, Hoang-Xuan K, El Hallani S, Idbaih A, Zelenika D, Andersson U, Henriksson R, Bergenheim AT, Feychting M, Lönn S, Ahlbom A, Schramm J, Linnebank M, Hemminki K, Kumar R, Hepworth SJ, Price A, Armstrong G, Liu Y, Gu X, Yu R, Lau C, Schoemaker M, Muir K, Swerdlow A, Lathrop M, Bondy M, Houlston RS

Abstract

To identify risk variants for glioma, we conducted a meta-analysis of two genome-wide association studies by genotyping 550K tagging SNPs in a total of 1,878 cases and 3,670 controls, with validation in three additional independent series totaling 2,545 cases and 2,953 controls. We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 x 10(-15)), 20q13.33 (rs6010620, RTEL1; P = 2.52 x 10(-12)) and 11q23.3 (rs498872, PHLDB1; P = 1.07 x 10(-8)). These data show that common low-penetrance susceptibility alleles contribute to the risk of developing glioma and provide insight into disease causation of this primary brain tumor.

MeSH Terms
Alleles Genetic Predisposition to Disease Genome-Wide Association Study Glioma/genetics Humans Linkage Disequilibrium/genetics Polymorphism, Single Nucleotide/genetics Reproducibility of Results
Authors & Affiliations
37 authors, click to expand affiliations / ORCID
Shete Sanjay
Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.
Hosking Fay J
Robertson Lindsay B
Dobbins Sara E
Sanson Marc
Malmer Beatrice
Simon Matthias
Marie Yannick
Boisselier Blandine
Delattre Jean-Yves
Hoang-Xuan Khe
El Hallani Soufiane
Idbaih Ahmed
Zelenika Diana
Andersson Ulrika
Henriksson Roger
Bergenheim A Tommy
Feychting Maria
Lönn Stefan
Ahlbom Anders
Schramm Johannes
Linnebank Michael
Hemminki Kari
Kumar Rajiv
Hepworth Sarah J
Price Amy
Armstrong Georgina
Liu Yanhong
Gu Xiangjun
Yu Robert
Lau Ching
Schoemaker Minouk
Muir Kenneth
Swerdlow Anthony
Lathrop Mark
Bondy Melissa
Houlston Richard S
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Article Info
Journal
Nature genetics
Abbr.
Nat Genet
ISSN
1546-1718
DOI
10.1038/ng.407
Published
2009-08-00
Epub
2009-00-05
Pages
899-904
Language
English
Region
United States
NLM ID
9216904
PMCID
PMC4501476
Subset
IM
Grants
Wellcome Trust · United Kingdom
NCI NIH HHS · T32 CA096520 · United States
Medical Research Council · G0000934 · United Kingdom
NCI NIH HHS · 5R01 CA119215 · United States
NCI NIH HHS · 5R01 CA070917 · United States
NCI NIH HHS · R01 CA070917 · United States
NCI NIH HHS · R01 CA119215 · United States
Cancer Research UK · C1298/A8362 · United Kingdom
External Links
PubMed source DOI: 10.1038/ng.407 PMC Full Text View journal details
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