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PMID: 2311579 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Members of the RCK potassium channel family are differentially expressed in the rat nervous system.

The EMBO journal ·Vol. 9 ·No. 3 ·1990-03-00 ·Pages 777-82

Beckh S, Pongs O

Abstract

mRNAs encoding four members of the RCK potassium channel family, named RCK1, RCK3, RCK4 and RCK5 have been analyzed by RNA blot hybridization experiments using specific RNA probes. Each probe recognizes a single mRNA species, their sizes ranging from approximately 4600 nucleotides up to approximately 11,000 nucleotides. The expression of RCK mRNAs as well as their developmental appearance in different regions of the central and peripheral rat nervous system has been investigated. The two most abundant RCK potassium channel mRNAs (RCK1 and RCK5) are predominantly expressed in the adult nervous system. RCK3 and RCK4 mRNAs are present throughout all developmental stages studied. The temporal and regional patterns observed are specific for each RCK potassium channel mRNA indicating that specific regulation of expression occurs. Differential mRNA expression might provide one mechanism for the generation of potassium channel diversity in vivo.

MeSH Terms
Animals Brain/metabolism Cranial Nerves/metabolism Ganglia, Spinal/metabolism Gene Expression Regulation Membrane Proteins/genetics Multigene Family Nucleic Acid Hybridization Peripheral Nerves/metabolism Plasmids Potassium Channels/metabolism RNA, Messenger/analysis,genetics Rats Rats, Inbred Strains Restriction Mapping Spinal Cord/metabolism Transcription, Genetic
Chemicals
Membrane Proteins Potassium Channels RNA, Messenger
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Beckh S
Lehrstuhl für Biochemie, Ruhr-Universität Bochum, FRG.
Pongs O
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33 references, click to expand
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1990-03-00
Pages
777-82
Language
English
Region
England
NLM ID
8208664
PMCID
PMC551736
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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