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PMID: 2462513 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Potassium channels expressed from rat brain cDNA have delayed rectifier properties.

FEBS letters ·Vol. 242 ·No. 1 ·1988-12-19 ·Pages 199-206

Stühmer W, Stocker M, Sakmann B, Seeburg P, Baumann A, Grupe A, Pongs O

Abstract

Injection into Xenopus oocytes of RNA synthesized in vitro using the rat brain cDNA RCK1 as a template or nuclear injection of the cDNA results in the expression of functional potassium channels. These channels exhibit properties similar to those of the non-inactivating delayed rectifier channel found in mammalian neurons and other excitable cells.

MeSH Terms

4-Aminopyridine Aminopyridines/pharmacology Animals Cell Membrane/metabolism Cerebral Cortex/analysis DNA/genetics Elapid Venoms/pharmacology Electric Conductivity Female Gene Expression Regulation Histamine Release/drug effects Membrane Potentials Oocytes/metabolism Peptides/pharmacology Potassium/pharmacology Potassium Channels/drug effects,physiology Rats Tetraethylammonium Tetraethylammonium Compounds/pharmacology Xenopus

Chemicals

Aminopyridines Elapid Venoms Peptides Potassium Channels Tetraethylammonium Compounds mast cell degranulating peptide Tetraethylammonium dendrotoxin DNA 4-Aminopyridine Potassium

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Stühmer W

Max-Planck-Institut für biophysikalische Chemie, Göttingen, FRG.

Stocker M

Sakmann B

Seeburg P

Baumann A

Grupe A

Pongs O

Article Info

Journal

FEBS letters

Abbr.

FEBS Lett

ISSN

0014-5793

DOI

10.1016/0014-5793(88)81015-9

Published

1988-12-19

Pages

199-206

Language

English

Region

England

NLM ID

0155157

Subset

External Links

PubMed source DOI: 10.1016/0014-5793(88)81015-9 View journal details

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Potassium channels expressed from rat brain cDNA have delayed rectifier properties.

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