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PMID: 22895430 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

The super elongation complex (SEC) family in transcriptional control.

Nature reviews. Molecular cell biology ·Vol. 13 ·No. 9 ·2012-09-00 ·Pages 543-7

Luo Z, Lin C, Shilatifard A

Abstract

The super elongation complex (SEC) consists of the RNA polymerase II (Pol II) elongation factors eleven-nineteen Lys-rich leukaemia (ELL) proteins, positive transcription elongation factor b (P-TEFb) and several frequent mixed lineage leukaemia (MLL) translocation partners. It is one of the most active P-TEFb-containing complexes required for rapid transcriptional induction in the presence or absence of paused Pol II. The SEC was found to regulate the transcriptional elongation checkpoint control (TECC) stage of transcription, and misregulation of this stage is associated with cancer pathogenesis. Recent studies have shown that the SEC belongs to a larger family of SEC-like complexes, which includes SEC-L2 and SEC-L3, each with distinct gene target specificities.

MeSH Terms
Gene Expression Regulation, Neoplastic Histone-Lysine N-Methyltransferase Humans Models, Genetic Multiprotein Complexes/metabolism Myeloid-Lymphoid Leukemia Protein/metabolism Neoplasms/genetics,metabolism,pathology Positive Transcriptional Elongation Factor B/metabolism RNA Polymerase II/metabolism Transcription, Genetic Transcriptional Elongation Factors/metabolism
Chemicals
ELL protein, human KMT2A protein, human Multiprotein Complexes Transcriptional Elongation Factors Myeloid-Lymphoid Leukemia Protein Histone-Lysine N-Methyltransferase Positive Transcriptional Elongation Factor B RNA Polymerase II
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Luo Zhuojuan
Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, Missouri 64110, USA.
Lin Chengqi
Shilatifard Ali
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Article Info
Journal
Nature reviews. Molecular cell biology
Abbr.
Nat Rev Mol Cell Biol
ISSN
1471-0080
DOI
10.1038/nrm3417
Published
2012-09-00
Epub
2012-00-16
Pages
543-7
Language
English
Region
England
NLM ID
100962782
Subset
IM
Grants
NCI NIH HHS · R01CA150265 · United States
NCI NIH HHS · R01CA89455 · United States
External Links
PubMed source DOI: 10.1038/nrm3417 View journal details
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