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PMID: 22404626 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

RNA polymerase II elongation control.

Annual review of biochemistry ·Vol. 81 ·2012-00-00 ·Pages 119-43

Zhou Q, Li T, Price DH

Abstract

Regulation of the elongation phase of transcription by RNA polymerase II (Pol II) is utilized extensively to generate the pattern of mRNAs needed to specify cell types and to respond to environmental changes. After Pol II initiates, negative elongation factors cause it to pause in a promoter proximal position. These polymerases are poised to respond to the positive transcription elongation factor P-TEFb, and then enter productive elongation only under the appropriate set of signals to generate full-length properly processed mRNAs. Recent global analyses of Pol II and elongation factors, mechanisms that regulate P-TEFb involving the 7SK small nuclear ribonucleoprotein (snRNP), factors that control both the negative and positive elongation properties of Pol II, and the mRNA processing events that are coupled with elongation are discussed.

MeSH Terms
Animals Eukaryota/metabolism Gene Expression Regulation Humans RNA Polymerase II/chemistry,metabolism Transcription Factors Transcription, Genetic
Chemicals
Transcription Factors RNA Polymerase II
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Zhou Qiang
Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA. qzhou@berkeley.edu
Li Tiandao
Price David H
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Article Info
Journal
Annual review of biochemistry
Abbr.
Annu Rev Biochem
ISSN
1545-4509
DOI
10.1146/annurev-biochem-052610-095910
Email
qzhou@berkeley.edu
Published
2012-00-00
Epub
2012-00-09
Pages
119-43
Language
English
Region
United States
NLM ID
2985150R
PMCID
PMC4273853
Subset
IM
Grants
NIAID NIH HHS · R21 AI074392 · United States
NIAID NIH HHS · AI095057 · United States
NIGMS NIH HHS · R01 GM035500 · United States
NIAID NIH HHS · R33 AI074392 · United States
NIAID NIH HHS · R01 AI041757 · United States
NIAID NIH HHS · AI074392 · United States
NIAID NIH HHS · AI41757 · United States
NIGMS NIH HHS · GM35500 · United States
External Links
PubMed source DOI: 10.1146/annurev-biochem-052610-095910 PMC Full Text View journal details
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