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PMID: 19074864 Published · ppublish English Journal Article Research Support, N.I.H., Intramural Review

Chromosomal rearrangements leading to MLL gene fusions: clinical and biological aspects.

Cancer research ·Vol. 68 ·No. 24 ·2008-12-15 ·Pages 10024-7

Harper DP, Aplan PD

Abstract

Rearrangements of the MLL gene located at 11q23 are common chromosomal abnormalities associated with acute leukemia, especially infant and therapy-related leukemias. A variety of chimeric oncoproteins resulting from these rearrangements has been described; all of these include the NH(2)-terminal region of MLL implicated in protein-protein interactions and transcriptional repression. Although the molecular basis for the oncogenic activity of MLL chimeric proteins is incompletely understood, it seems to be derived, at least in part, through activation of clustered homeobox (HOX) genes. Here, we survey MLL gene rearrangements that are associated with acute leukemia and discuss molecular pathways leading to these rearrangements.

MeSH Terms
Gene Fusion Gene Rearrangement Histone-Lysine N-Methyltransferase Humans Infant Leukemia/genetics Leukemia, Myeloid, Acute/genetics Leukemia, T-Cell/genetics Myeloid-Lymphoid Leukemia Protein/genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics
Chemicals
KMT2A protein, human Myeloid-Lymphoid Leukemia Protein Histone-Lysine N-Methyltransferase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Harper David P
Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20889, USA.
Aplan Peter D
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Article Info
Journal
Cancer research
Abbr.
Cancer Res
ISSN
1538-7445
DOI
10.1158/0008-5472.CAN-08-2208
Published
2008-12-15
Pages
10024-7
Language
English
Region
United States
NLM ID
2984705R
PMCID
PMC2614694
Subset
IM
Grants
Intramural NIH HHS · Z01 SC010379-07 · United States
External Links
PubMed source DOI: 10.1158/0008-5472.CAN-08-2208 PMC Full Text View journal details
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