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PMID: 2254444 Published · ppublish English Comparative Study Journal Article Review

Nuclear thyroid hormone receptors.

The Journal of clinical investigation ·Vol. 86 ·No. 6 ·1990-12-00 ·Pages 1777-82

Lazar MA, Chin WW

Abstract

暂无摘要

MeSH Terms
Animals Base Sequence Cloning, Molecular DNA-Binding Proteins/physiology Gene Expression Regulation Humans Molecular Sequence Data Proto-Oncogene Proteins/physiology Receptors, Thyroid Hormone/physiology Regulatory Sequences, Nucleic Acid Triiodothyronine/physiology
Chemicals
DNA-Binding Proteins Proto-Oncogene Proteins Receptors, Thyroid Hormone Triiodothyronine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Lazar M A
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104.
Chin W W
References (76)
76 references, click to expand
  1. Chromosomal localisation of the human homologues to the oncogenes erbA and B.
    EMBO J. 1984 Jan;3(1):159-63 PMID: 6323162
  2. Hormonal regulation of the growth hormone gene. Relationship of the rate of transcription to the level of nuclear thyroid hormone-receptor complexes.
    J Biol Chem. 1984 May 25;259(10):6284-91 PMID: 6327674
  3. A human c-erbA oncogene homologue is closely proximal to the chromosome 17 breakpoint in acute promyelocytic leukemia.
    Proc Natl Acad Sci U S A. 1984 Jul;81(14):4495-9 PMID: 6589608
  4. Domain structure of human glucocorticoid receptor and its relationship to the v-erb-A oncogene product.
    Nature. 1985 Dec 19-1986 Jan 1;318(6047):670-2 PMID: 3841189
  5. Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A.
    Nature. 1986 Mar 13-19;320(6058):134-9 PMID: 3754034
  6. Cloning of the chicken progesterone receptor.
    Proc Natl Acad Sci U S A. 1986 Aug;83(15):5424-8 PMID: 2426697
  7. Molecular cloning of the chicken progesterone receptor.
    Science. 1986 Aug 15;233(4765):767-70 PMID: 2426779
  8. Functional domains of the human glucocorticoid receptor.
    Cell. 1986 Aug 29;46(5):645-52 PMID: 3742595
  9. Cloning and sequence analysis of rabbit progesterone-receptor complementary DNA.
    Proc Natl Acad Sci U S A. 1986 Dec;83(23):9045-9 PMID: 3538016
  10. A superfamily of potentially oncogenic hormone receptors.
    Nature. 1986 Dec 18-31;324(6098):615-7 PMID: 3025739
  11. The c-erb-A protein is a high-affinity receptor for thyroid hormone.
    Nature. 1986 Dec 18-31;324(6098):635-40 PMID: 2879242
  12. The c-erb-A gene encodes a thyroid hormone receptor.
    Nature. 1986 Dec 18-31;324(6098):641-6 PMID: 2879243
  13. Molecular cloning of complementary DNA encoding the avian receptor for vitamin D.
    Science. 1987 Mar 6;235(4793):1214-7 PMID: 3029866
  14. Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor.
    Science. 1987 Jul 17;237(4812):268-75 PMID: 3037703
  15. Thyroid hormone receptor binds to a site in the rat growth hormone promoter required for induction by thyroid hormone.
    Proc Natl Acad Sci U S A. 1987 Aug;84(16):5670-4 PMID: 3475698
  16. Identification of a novel thyroid hormone receptor expressed in the mammalian central nervous system.
    Science. 1987 Sep 25;237(4822):1610-4 PMID: 3629259
  17. Advances in our understanding of thyroid hormone action at the cellular level.
    Endocr Rev. 1987 Aug;8(3):288-308 PMID: 3308445
  18. A c-erb-A binding site in rat growth hormone gene mediates trans-activation by thyroid hormone.
    Nature. 1987 Oct 22-28;329(6141):738-41 PMID: 3313046
  19. A novel thyroid hormone receptor encoded by a cDNA clone from a human testis library.
    Science. 1987 Nov 6;238(4828):788-91 PMID: 3672126
  20. A human retinoic acid receptor which belongs to the family of nuclear receptors.
    Nature. 1987 Dec 3-9;330(6147):444-50 PMID: 2825025
  21. Identification of a receptor for the morphogen retinoic acid.
    Nature. 1987 Dec 17-23;330(6149):624-9 PMID: 2825036
  22. Zinc fingers: gilt by association.
    Cell. 1988 Jan 15;52(1):1-3 PMID: 3125980
  23. Regulation of gene expression by thyroid hormone.
    J Clin Invest. 1988 Apr;81(4):957-67 PMID: 3280604
  24. Molecular cloning of human and rat complementary DNA encoding androgen receptors.
    Science. 1988 Apr 15;240(4850):324-6 PMID: 3353726
  25. Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus.
    Cell. 1989 Apr 7;57(1):31-9 PMID: 2539258
  26. Identification of a thyroid hormone receptor that is pituitary-specific.
    Science. 1989 Apr 7;244(4900):76-9 PMID: 2539642
  27. Thyroid hormone regulation of the rat glycoprotein hormone alpha-subunit gene promoter activity.
    J Biol Chem. 1989 Apr 25;264(12):6886-91 PMID: 2468663
  28. Retinoic acid regulates growth hormone gene expression.
    Nature. 1989 May 18;339(6221):231-4 PMID: 2716850
  29. Regulation of expression of the alternative mRNAs of the rat alpha-thyroid hormone receptor gene.
    J Biol Chem. 1989 May 25;264(15):8900-4 PMID: 2722806
  30. A novel member of the thyroid/steroid hormone receptor family is encoded by the opposite strand of the rat c-erbA alpha transcriptional unit.
    Mol Cell Biol. 1989 Mar;9(3):1128-36 PMID: 2542765
  31. Thyroid hormones regulate rat thyrotropin beta gene promoter activity expressed in GH3 cells.
    Mol Endocrinol. 1989 Apr;3(4):709-16 PMID: 2542780
  32. Trans-activation by thyroid hormone receptors: functional parallels with steroid hormone receptors.
    Proc Natl Acad Sci U S A. 1989 May;86(10):3494-8 PMID: 2726731
  33. Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist.
    Nature. 1989 Jun 22;339(6226):593-7 PMID: 2733791
  34. Repression of transcription mediated at a thyroid hormone response element by the v-erb-A oncogene product.
    Nature. 1989 Jul 20;340(6230):242-4 PMID: 2569164
  35. Dual regulatory role for thyroid-hormone receptors allows control of retinoic-acid receptor activity.
    Nature. 1989 Aug 24;340(6235):653-6 PMID: 2549424
  36. Nuclear and nucleolar targeting sequences of c-erb-A, c-myb, N-myc, p53, HSP70, and HIV tat proteins.
    J Biol Chem. 1989 Oct 25;264(30):18019-23 PMID: 2553699
  37. Cloning of human androgen receptor complementary DNA and localization to the X chromosome.
    Science. 1988 Apr 15;240(4850):327-30 PMID: 3353727
  38. Characterization of a thyroid hormone receptor expressed in human kidney and other tissues.
    Proc Natl Acad Sci U S A. 1988 Apr;85(8):2781-5 PMID: 3357890
  39. The N-terminal region of the chicken progesterone receptor specifies target gene activation.
    Nature. 1988 May 12;333(6169):185-8 PMID: 2835683
  40. Cloning and expression of full-length cDNA encoding human vitamin D receptor.
    Proc Natl Acad Sci U S A. 1988 May;85(10):3294-8 PMID: 2835767
  41. Rat growth hormone gene expression. Both cell-specific and thyroid hormone response elements are required for thyroid hormone regulation.
    J Biol Chem. 1988 Jun 5;263(16):7821-9 PMID: 2836398
  42. Isolation of a cDNA clone encoding a biologically active thyroid hormone receptor.
    Proc Natl Acad Sci U S A. 1988 Jul;85(14):5031-5 PMID: 2899322
  43. The thyroid hormone receptor binds with opposite transcriptional effects to a common sequence motif in thyroid hormone and estrogen response elements.
    Cell. 1988 Jul 29;54(3):313-23 PMID: 3396073
  44. Multiple sequences encoding potential thyroid hormone receptors isolated from mouse skeletal muscle cDNA libraries.
    Nucleic Acids Res. 1988 Jul 11;16(13):6248 PMID: 3399404
  45. Thyroid hormone receptor alpha isoforms generated by alternative splicing differentially activate myosin HC gene transcription.
    Nature. 1988 Aug 11;334(6182):539-42 PMID: 2841611
  46. Alternative splicing generates messages encoding rat c-erbA proteins that do not bind thyroid hormone.
    Proc Natl Acad Sci U S A. 1988 Aug;85(16):5804-8 PMID: 2901090
  47. Regulation of two c-erbA messenger ribonucleic acids in rat GH3 cells by thyroid hormone.
    Mol Endocrinol. 1988 Jun;2(6):479-84 PMID: 2901667
  48. Sequences essential for activity of the thyroid hormone responsive transcription stimulatory element of the rat growth hormone gene.
    Mol Endocrinol. 1988 Jun;2(6):536-42 PMID: 2843760
  49. The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer.
    Cell. 1988 Oct 7;55(1):145-56 PMID: 3167974
  50. How eukaryotic transcriptional activators work.
    Nature. 1988 Oct 20;335(6192):683-9 PMID: 3050531
  51. Identification of a rat c-erbA alpha-related protein which binds deoxyribonucleic acid but does not bind thyroid hormone.
    Mol Endocrinol. 1988 Oct;2(10):893-901 PMID: 2903438
  52. Retinoic acid and thyroid hormone induce gene expression through a common responsive element.
    Nature. 1988 Nov 17;336(6196):262-5 PMID: 2848197
  53. Functional characterization of the rat growth hormone promoter elements required for induction by thyroid hormone with and without a co-transfected beta type thyroid hormone receptor.
    J Biol Chem. 1989 Jan 5;264(1):178-82 PMID: 2909514
  54. Characterization of a third human thyroid hormone receptor coexpressed with other thyroid hormone receptors in several tissues.
    Mol Endocrinol. 1988 Nov;2(11):1087-92 PMID: 2464749
  55. Human carboxyl-terminal variant of alpha-type c-erbA inhibits trans-activation by thyroid hormone receptors without binding thyroid hormone.
    Proc Natl Acad Sci U S A. 1989 Oct;86(20):7771-4 PMID: 2554288
  56. Generalized resistance to thyroid hormone associated with a mutation in the ligand-binding domain of the human thyroid hormone receptor beta.
    Proc Natl Acad Sci U S A. 1989 Nov;86(22):8977-81 PMID: 2510172
  57. Positive and negative regulation of gene transcription by a retinoic acid-thyroid hormone receptor heterodimer.
    Cell. 1989 Nov 17;59(4):697-708 PMID: 2555064
  58. A retinoic acid-responsive element is present in the 5' flanking region of the laminin B1 gene.
    Proc Natl Acad Sci U S A. 1989 Dec;86(23):9099-103 PMID: 2556699
  59. Differential and tissue-specific regulation of the multiple rat c-erbA messenger RNA species by thyroid hormone.
    J Clin Invest. 1990 Jan;85(1):101-5 PMID: 2153150
  60. A base mutation of the C-erbA beta thyroid hormone receptor in a kindred with generalized thyroid hormone resistance. Molecular heterogeneity in two other kindreds.
    J Clin Invest. 1990 Jan;85(1):93-100 PMID: 2153155
  61. A domain containing leucine-zipper-like motifs mediate novel in vivo interactions between the thyroid hormone and retinoic acid receptors.
    Mol Endocrinol. 1989 Oct;3(10):1610-26 PMID: 2558297
  62. Binding of thyroid hormone receptors to the rat thyrotropin-beta gene.
    Mol Endocrinol. 1989 Sep;3(9):1359-68 PMID: 2608064
  63. Identification of nuclear factors that enhance binding of the thyroid hormone receptor to a thyroid hormone response element.
    Mol Endocrinol. 1989 Sep;3(9):1434-42 PMID: 2608066
  64. A nuclear factor that enhances binding of thyroid hormone receptors to thyroid hormone response elements.
    J Biol Chem. 1990 Feb 15;265(5):2500-4 PMID: 1968058
  65. A major thyroid hormone response element in the third intron of the rat growth hormone gene.
    EMBO J. 1990 Mar;9(3):887-96 PMID: 2155782
  66. Mutations of the rat growth hormone promoter which increase and decrease response to thyroid hormone define a consensus thyroid hormone response element.
    Mol Endocrinol. 1989 Dec;3(12):1996-2004 PMID: 2628734
  67. Characterization and colocalization of steroid binding and dimerization activities in the mouse estrogen receptor.
    Cell. 1990 Mar 23;60(6):953-62 PMID: 2317866
  68. Binding of 3,5,3'-triiodothyronine (T3) and its analogs to the in vitro translational products of c-erbA protooncogenes: differences in the affinity of the alpha- and beta-forms for the acetic acid analog and failure of the human testis and kidney alpha-2 products to bind T3.
    Mol Endocrinol. 1990 Feb;4(2):227-34 PMID: 2158622
  69. Identification of a thyroid hormone response element in the malic enzyme gene.
    J Biol Chem. 1990 May 5;265(13):7395-400 PMID: 2332433
  70. Identification of multiple thyroid hormone response elements located far upstream from the rat S14 promoter.
    J Biol Chem. 1990 May 15;265(14):8136-43 PMID: 2159469
  71. Isolation of a cDNA encoding human Rev-ErbA alpha: transcription from the noncoding DNA strand of a thyroid hormone receptor gene results in a related protein that does not bind thyroid hormone.
    DNA Cell Biol. 1990 Mar;9(2):77-83 PMID: 1971514
  72. Mutational analysis identifies a new functional domain of the thyroid hormone receptor.
    Mol Endocrinol. 1990 May;4(5):715-20 PMID: 2274055
  73. Thyroid hormone aporeceptor represses T3-inducible promoters and blocks activity of the retinoic acid receptor.
    New Biol. 1989 Dec;1(3):329-36 PMID: 2562125
  74. Inhibition of thyroid hormone action by a non-hormone binding c-erbA protein generated by alternative mRNA splicing.
    Nature. 1989 Feb 16;337(6208):659-61 PMID: 2537467
  75. Growth hormone gene transcription is regulated by thyroid and glucocorticoid hormones in cultured rat pituitary tumor cells.
    J Biol Chem. 1982 Oct 10;257(19):11627-32 PMID: 7118899
  76. Role of the v-erbA and v-erbB oncogenes of avian erythroblastosis virus in erythroid cell transformation.
    Cell. 1983 Aug;34(1):7-9 PMID: 6309413
Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI114906
Published
1990-12-00
Pages
1777-82
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC329808
Subset
IM
External Links
PubMed source DOI: 10.1172/JCI114906 PMC Full Text View journal details
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