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PMID: 2879242 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The c-erb-A protein is a high-affinity receptor for thyroid hormone.

Nature ·Vol. 324 ·No. 6098 ·1986-00-00 ·Pages 635-40

Sap J, Muñoz A, Damm K, Goldberg Y, Ghysdael J, Leutz A, Beug H, Vennström B

Abstract

Hormone binding and localization of the c-erb-A protein suggest that it is a receptor for thyroid hormone, a nuclear protein that binds to DNA and activates transcription. In contrast, the product of the viral oncogene v-erb-A is defective in binding the hormone but is still located in the nucleus.

MeSH Terms

Amino Acid Sequence Animals Base Sequence Cloning, Molecular DNA/metabolism Genes Humans Proto-Oncogene Proteins/genetics,metabolism Proto-Oncogenes Receptors, Thyroid Hormone/genetics Retroviridae/genetics Triiodothyronine/metabolism

Chemicals

Proto-Oncogene Proteins Receptors, Thyroid Hormone Triiodothyronine DNA

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Sap J

Muñoz A

Damm K

Goldberg Y

Ghysdael J

Leutz A

Beug H

Vennström B

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/324635a0

Published

1986-00-00

Pages

635-40

Language

English

Region

England

NLM ID

0410462

Subset

Databases

GENBANK

Y00987

External Links

PubMed source DOI: 10.1038/324635a0 View journal details

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The c-erb-A protein is a high-affinity receptor for thyroid hormone.

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