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PMID: 22307041 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Peli: a family of signal-responsive E3 ubiquitin ligases mediating TLR signaling and T-cell tolerance.

Cellular & molecular immunology ·Vol. 9 ·No. 2 ·2012-03-00 ·Pages 113-22

Jin W, Chang M, Sun SC

Abstract

E3 ubiquitin ligases play a crucial role in regulating immune receptor signaling and modulating immune homeostasis and activation. One emerging family of such E3s is the Pelle-interacting (Peli) proteins, characterized by the presence of a cryptic forkhead-associated domain involved in substrate binding and an atypical RING domain mediating formation of both lysine (K) 63- and K48-linked polyubiquitin chains. A well-recognized function of Peli family members is participation in the signal transduction mediated by Toll-like receptors (TLRs) and IL-1 receptor. Recent gene targeting studies have provided important insights into the in vivo functions of Peli1 in the regulation of TLR signaling and inflammation. These studies have also extended the biological functions of Peli1 to the regulation of T-cell tolerance. Consistent with its immunoregulatory functions, Peli1 responds to different immune stimuli for its gene expression and catalytic activation. In this review, we discuss the recent progress, as well as the historical perspectives in the regulation and biological functions of Peli.

MeSH Terms
Animals Humans Immune Tolerance Immunomodulation Nuclear Proteins/immunology Receptors, Interleukin-1/immunology Signal Transduction/immunology T-Lymphocytes/immunology Toll-Like Receptors/immunology Ubiquitin-Protein Ligases/immunology
Chemicals
Nuclear Proteins Receptors, Interleukin-1 Toll-Like Receptors PELI1 protein, human Ubiquitin-Protein Ligases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Jin Wei
Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. JinW@mskcc.org
Chang Mikyoung
Sun Shao-Cong
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Article Info
Journal
Cellular & molecular immunology
Abbr.
Cell Mol Immunol
ISSN
2042-0226
DOI
10.1038/cmi.2011.60
Email
jinw@mskcc.org
Published
2012-03-00
Epub
2012-00-06
Pages
113-22
Language
English
Region
China
NLM ID
101242872
PMCID
PMC4002811
Subset
IM
Grants
NIAID NIH HHS · R01 AI064639 · United States
NIAID NIH HHS · AI064639 · United States
NIAID NIH HHS · R01 AI057555 · United States
NIGMS NIH HHS · GM84459 · United States
NIAID NIH HHS · R37 AI064639 · United States
NIAID NIH HHS · AI057555 · United States
NIGMS NIH HHS · R01 GM084459 · United States
External Links
PubMed source DOI: 10.1038/cmi.2011.60 PMC Full Text View journal details
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