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PMID: 21173796 Published · ppublish English Journal Article Review

Non-canonical NF-κB signaling pathway.

Cell research ·Vol. 21 ·No. 1 ·2011-01-00 ·Pages 71-85

Sun SC

Abstract

The non-canonical NF-κB pathway is an important arm of NF-κB signaling that predominantly targets activation of the p52/RelB NF-κB complex. This pathway depends on the inducible processing of p100, a molecule functioning as both the precursor of p52 and a RelB-specific inhibitor. A central signaling component of the non-canonical pathway is NF-κB-inducing kinase (NIK), which integrates signals from a subset of TNF receptor family members and activates a downstream kinase, IκB kinase-α (IKKα), for triggering p100 phosphorylation and processing. A unique mechanism of NIK regulation is through its fate control: the basal level of NIK is kept low by a TRAF-cIAP destruction complex and signal-induced non-canonical NF-κB signaling involves NIK stabilization. Tight control of the fate of NIK is important, since deregulated NIK accumulation is associated with lymphoid malignancies.

MeSH Terms
Endonucleases Humans I-kappa B Kinase/metabolism NF-kappa B/metabolism,physiology Nuclear Proteins/metabolism Protein Serine-Threonine Kinases/metabolism Signal Transduction
Chemicals
NF-kappa B Nuclear Proteins Protein Serine-Threonine Kinases I-kappa B Kinase NF-kappa B kinase Endonucleases SND1 protein, human
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Sun Shao-Cong
Department of Immunology, The University of Texas MD Anderson Cancer Center, The University of Texas Graduate School of Biomedical Sciences at Houston, 7455 Fannin Street, Box 902, Houston, TX 77030, USA. ssun@mdanderson.org
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Article Info
Journal
Cell research
Abbr.
Cell Res
ISSN
1748-7838
DOI
10.1038/cr.2010.177
Email
ssun@mdanderson.org
Published
2011-01-00
Epub
2010-00-21
Pages
71-85
Language
English
Region
England
NLM ID
9425763
PMCID
PMC3193406
Subset
IM
External Links
PubMed source DOI: 10.1038/cr.2010.177 PMC Full Text View journal details
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