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PMID: 21135871 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Expanding role of ubiquitination in NF-κB signaling.

Cell research ·Vol. 21 ·No. 1 ·2011-01-00 ·Pages 6-21

Liu S, Chen ZJ

Abstract

Best known for its role in targeting protein degradation by the proteasome, ubiquitin modification has also emerged as an important mechanism that regulates cell signaling through proteasome-independent mechanisms. The role of ubiquitin as a versatile signaling tag is characteristically illustrated in the NF-κB pathways, which regulate a variety of physiological and pathological processes in response to diverse stimuli. Here, we review the role of ubiquitination in different steps of the NF-κB signaling cascades, focusing on recent advances in understanding the mechanisms of protein kinase activation by polyubiquitin chains in different pathways that converge on NF-κB.

MeSH Terms
Apoptosis Humans I-kappa B Proteins/metabolism NF-kappa B/metabolism,physiology Signal Transduction Tumor Necrosis Factor-alpha/metabolism Ubiquitin/metabolism,physiology Ubiquitination/physiology
Chemicals
I-kappa B Proteins NF-kappa B Tumor Necrosis Factor-alpha Ubiquitin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Liu Siqi
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.
Chen Zhijian J
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Article Info
Journal
Cell research
Abbr.
Cell Res
ISSN
1748-7838
DOI
10.1038/cr.2010.170
Published
2011-01-00
Epub
2010-00-07
Pages
6-21
Language
English
Region
England
NLM ID
9425763
PMCID
PMC3193409
Subset
IM
Grants
NIGMS NIH HHS · R01-GM63692 · United States
Howard Hughes Medical Institute · United States
NIGMS NIH HHS · R01 GM063692-10 · United States
NIGMS NIH HHS · R01 GM063692-09 · United States
NIGMS NIH HHS · R01 GM063692 · United States
External Links
PubMed source DOI: 10.1038/cr.2010.170 PMC Full Text View journal details
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