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PMID: 1322675 Published · ppublish English Comparative Study Journal Article Review

Two TNF receptors.

Immunology today ·Vol. 13 ·No. 5 ·1992-05-00 ·Pages 151-3

Tartaglia LA, Goeddel DV

Abstract

In the past few years, considerable progress has been made on the identification and characterization of tumor necrosis factor (TNF) receptors. The relative roles played by the two receptor types in signaling the diverse functions of TNF are less clear. Here, Louis Tartaglia and David Goeddel summarize progress to date and propose a model of TNF receptor triggering that reconciles the seemingly conflicting data.

MeSH Terms

Animals Antibodies/immunology Cell Line Cloning, Molecular Genes Humans Mice Models, Biological Molecular Weight Receptor Aggregation Receptors, Cell Surface/classification,genetics,immunology,isolation & purification,physiology Receptors, Tumor Necrosis Factor Sequence Homology, Nucleic Acid Signal Transduction Tumor Necrosis Factor-alpha

Chemicals

Antibodies Receptors, Cell Surface Receptors, Tumor Necrosis Factor Tumor Necrosis Factor-alpha

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Tartaglia L A

Genentech, South San Francisco, CA 94080.

Goeddel D V

Article Info

Journal

Immunology today

Abbr.

Immunol Today

ISSN

0167-5699

DOI

10.1016/0167-5699(92)90116-O

Published

1992-05-00

Pages

151-3

Language

English

Region

England

NLM ID

8008346

Subset

External Links

PubMed source DOI: 10.1016/0167-5699(92)90116-O

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Two TNF receptors.

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