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PMID: 22265227 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Insulators, long-range interactions, and genome function.

Current opinion in genetics & development ·Vol. 22 ·No. 2 ·2012-04-00 ·Pages 86-92

Yang J, Corces VG

Abstract

Insulators are DNA-protein complexes that can mediate interactions in cis or trans between different regions of the genome. Although originally defined on the basis of their ability to block enhancer-promoter communication or to serve as barriers against the spreading of heterochromatin in reporter systems, recent information suggests that their function is more nuanced and depends on the nature of the sequences brought together by contacts between specific insulator sites. Here we provide an overview of new evidence that has uncovered a wide range of functions for these sequences in addition to their two classical roles.

MeSH Terms

Animals Chromatin/genetics Enhancer Elements, Genetic Genome Humans Insulator Elements Recombination, Genetic

Chemicals

Chromatin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Yang Jingping

Department of Biology, Emory University, Atlanta, GA 30322, USA.

Corces Victor G

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Article Info

Journal

Current opinion in genetics & development

Abbr.

Curr Opin Genet Dev

ISSN

1879-0380

DOI

10.1016/j.gde.2011.12.007

Published

2012-04-00

Epub

2012-00-19

Pages

86-92

Language

English

Region

England

NLM ID

9111375

PMCID

PMC3337973

Subset

Grants

NIGMS NIH HHS · R01 GM035463 · United States

NIGMS NIH HHS · R01 GM035463-25 · United States

NIGMS NIH HHS · GM35463 · United States

External Links

PubMed source DOI: 10.1016/j.gde.2011.12.007 PMC Full Text View journal details

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Insulators, long-range interactions, and genome function.

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