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PMID: 22033837 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Protein intrinsic disorder as a flexible armor and a weapon of HIV-1.

Cellular and molecular life sciences : CMLS ·Vol. 69 ·No. 8 ·2012-04-00 ·Pages 1211-59

Xue B, Mizianty MJ, Kurgan L, Uversky VN

Abstract

Many proteins and protein regions are disordered in their native, biologically active states. These proteins/regions are abundant in different organisms and carry out important biological functions that complement the functional repertoire of ordered proteins. Viruses, with their highly compact genomes, small proteomes, and high adaptability for fast change in their biological and physical environment utilize many of the advantages of intrinsic disorder. In fact, viral proteins are generally rich in intrinsic disorder, and intrinsically disordered regions are commonly used by viruses to invade the host organisms, to hijack various host systems, and to help viruses in accommodation to their hostile habitats and to manage their economic usage of genetic material. In this review, we focus on the structural peculiarities of HIV-1 proteins, on the abundance of intrinsic disorder in viral proteins, and on the role of intrinsic disorder in their functions.

MeSH Terms
HIV-1/chemistry,enzymology,metabolism Models, Molecular Protein Conformation Retroviridae Proteins/chemistry,metabolism
Chemicals
Retroviridae Proteins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Xue Bin
Department of Molecular Medicine, University of South Florida, College of Medicine, Tampa, FL 33612, USA.
Mizianty Marcin J
Kurgan Lukasz
Uversky Vladimir N
References (483)
483 references, click to expand
  1. Gulliver's travels in HIVland.
    Nature. 2001 Apr 19;410(6831):963-7 PMID: 11309625
  2. Chemical synthesis and single channel properties of tetrameric and pentameric TASPs (template-assembled synthetic proteins) derived from the transmembrane domain of HIV virus protein u (Vpu).
    J Biol Chem. 2004 Apr 23;279(17):17483-9 PMID: 14752102
  3. CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5.
    Nature. 1996 Nov 14;384(6605):184-7 PMID: 8906796
  4. Protein intrinsic disorder and human papillomaviruses: increased amount of disorder in E6 and E7 oncoproteins from high risk HPVs.
    J Proteome Res. 2006 Aug;5(8):1829-42 PMID: 16889404
  5. Effect of mutations affecting the p6 gag protein on human immunodeficiency virus particle release.
    Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3195-9 PMID: 2014240
  6. Selective assembly of HIV-1 Vif-Cul5-ElonginB-ElonginC E3 ubiquitin ligase complex through a novel SOCS box and upstream cysteines.
    Genes Dev. 2004 Dec 1;18(23):2867-72 PMID: 15574593
  7. Expression, purification, and activities of full-length and truncated versions of the integral membrane protein Vpu from HIV-1.
    Protein Sci. 2002 Mar;11(3):546-57 PMID: 11847278
  8. Domains upstream of the protease (PR) in human immunodeficiency virus type 1 Gag-Pol influence PR autoprocessing.
    J Virol. 1995 Jun;69(6):3878-84 PMID: 7745738
  9. Crystal structure of human cyclophilin A bound to the amino-terminal domain of HIV-1 capsid.
    Cell. 1996 Dec 27;87(7):1285-94 PMID: 8980234
  10. The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu protein.
    Cell Host Microbe. 2008 Apr 17;3(4):245-52 PMID: 18342597
  11. Detection of a trimeric human immunodeficiency virus type 1 Gag intermediate is dependent on sequences in the matrix protein, p17.
    J Virol. 1998 Sep;72(9):7659-63 PMID: 9696871
  12. Delineation of a region of the human immunodeficiency virus type 1 gp120 glycoprotein critical for interaction with the CD4 receptor.
    Cell. 1987 Sep 11;50(6):975-85 PMID: 2441877
  13. HIV1 Nef: the Machiavelli of cellular activation.
    Res Virol. 1997 Jan-Feb;148(1):58-64 PMID: 9017836
  14. Amyloidogenesis of natively unfolded proteins.
    Curr Alzheimer Res. 2008 Jun;5(3):260-87 PMID: 18537543
  15. Equine Infectious Anemia Virus (EIAV): what has HIV's country cousin got to tell us?
    Vet Res. 2004 Jul-Aug;35(4):485-512 PMID: 15236678
  16. Solution structure and orientation of the transmembrane anchor domain of the HIV-1-encoded virus protein U by high-resolution and solid-state NMR spectroscopy.
    Biochemistry. 1999 Apr 20;38(16):5272-82 PMID: 10213635
  17. Structural preordering in the N-terminal region of ribosomal protein S4 revealed by heteronuclear NMR spectroscopy.
    Biochemistry. 2000 Nov 7;39(44):13602-13 PMID: 11063598
  18. Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners.
    BMC Genomics. 2008;9 Suppl 1:S1 PMID: 18366598
  19. Structures of the HIV-1 capsid protein dimerization domain at 2.6 A resolution.
    Acta Crystallogr D Biol Crystallogr. 1999 Jan;55(Pt 1):85-92 PMID: 10089398
  20. Role of HIV-1 Vpr in AIDS pathogenesis: relevance and implications of intravirion, intracellular and free Vpr.
    Biomed Pharmacother. 2003 Jan;57(1):20-4 PMID: 12642033
  21. Conformational changes induced in the envelope glycoproteins of the human and simian immunodeficiency viruses by soluble receptor binding.
    J Virol. 1993 Dec;67(12):7383-93 PMID: 7693970
  22. Potent suppression of viral infectivity by the peptides that inhibit multimerization of human immunodeficiency virus type 1 (HIV-1) Vif proteins.
    J Biol Chem. 2003 Feb 21;278(8):6596-602 PMID: 12480936
  23. Cyclophilin A is required for TRIM5{alpha}-mediated resistance to HIV-1 in Old World monkey cells.
    Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14849-53 PMID: 16203999
  24. Nucleocapsid zinc fingers detected in retroviruses: EXAFS studies of intact viruses and the solution-state structure of the nucleocapsid protein from HIV-1.
    Protein Sci. 1992 May;1(5):563-74 PMID: 1304355
  25. vpu transmembrane peptide structure obtained by site-specific fourier transform infrared dichroism and global molecular dynamics searching.
    Biophys J. 1999 Sep;77(3):1594-601 PMID: 10465770
  26. HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages.
    Nat Med. 1999 Sep;5(9):997-103 PMID: 10470075
  27. Structure of the amino-terminal core domain of the HIV-1 capsid protein.
    Science. 1996 Jul 12;273(5272):231-5 PMID: 8662505
  28. Polyglutamine diseases: protein cleavage and aggregation.
    Curr Opin Neurobiol. 1999 Oct;9(5):566-70 PMID: 10508741
  29. The Vpr protein of human immunodeficiency virus type 1 binds to nucleocapsid protein p7 in vitro.
    Biochem Biophys Res Commun. 1996 Jan 5;218(1):352-5 PMID: 8573160
  30. The angiogenesis induced by HIV-1 tat protein is mediated by the Flk-1/KDR receptor on vascular endothelial cells.
    Nat Med. 1996 Dec;2(12):1371-5 PMID: 8946838
  31. Intrinsically disordered proteins in human diseases: introducing the D2 concept.
    Annu Rev Biophys. 2008;37:215-46 PMID: 18573080
  32. Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein.
    Nature. 2002 Aug 8;418(6898):646-50 PMID: 12167863
  33. Structure-function relationships of the HIV-1 envelope V3 loop tropism determinant: evidence for two distinct conformations.
    AIDS. 1993 May;7(5):639-46 PMID: 7686374
  34. HIV and apoptosis death and the mitochondrion.
    J Exp Med. 2001 Feb 19;193(4):F11-4 PMID: 11181706
  35. The HIV-1 transcriptional activator Tat has potent nucleic acid chaperoning activities in vitro.
    Nucleic Acids Res. 2008 Jun;36(10):3389-400 PMID: 18442994
  36. p6Gag is required for particle production from full-length human immunodeficiency virus type 1 molecular clones expressing protease.
    J Virol. 1995 Nov;69(11):6810-8 PMID: 7474093
  37. Mass spectrometry analysis of HIV-1 Vif reveals an increase in ordered structure upon oligomerization in regions necessary for viral infectivity.
    Proteins. 2007 Nov 1;69(2):270-84 PMID: 17598142
  38. NMR structure of the HIV-1 regulatory protein Vpr in H2O/trifluoroethanol. Comparison with the Vpr N-terminal (1-51) and C-terminal (52-96) domains.
    Eur J Biochem. 2002 Aug;269(15):3779-88 PMID: 12153575
  39. Effect of mutations in the nucleocapsid protein (NCp7) upon Pr160(gag-pol) and tRNA(Lys) incorporation into human immunodeficiency virus type 1.
    J Virol. 1997 Jun;71(6):4378-84 PMID: 9151827
  40. The multifaceted role of HIV Nef.
    Res Virol. 1997 Jan-Feb;148(1):30-3 PMID: 9017830
  41. Role of vif in replication of human immunodeficiency virus type 1 in CD4+ T lymphocytes.
    J Virol. 1992 Nov;66(11):6489-95 PMID: 1357189
  42. Vif is a RNA chaperone that could temporally regulate RNA dimerization and the early steps of HIV-1 reverse transcription.
    Nucleic Acids Res. 2007;35(15):5141-53 PMID: 17660191
  43. Oligomerization state and supramolecular structure of the HIV-1 Vpu protein transmembrane segment in phospholipid bilayers.
    Protein Sci. 2010 Oct;19(10):1877-96 PMID: 20669237
  44. Characterization of deletion mutations in the capsid region of human immunodeficiency virus type 1 that affect particle formation and Gag-Pol precursor incorporation.
    J Virol. 1995 Oct;69(10):6106-14 PMID: 7666514
  45. HIV-1 Vif blocks the antiviral activity of APOBEC3G by impairing both its translation and intracellular stability.
    Mol Cell. 2003 Sep;12(3):591-601 PMID: 14527406
  46. RNA and DNA binding properties of HIV-1 Vif protein: a fluorescence study.
    J Biol Chem. 2007 Sep 7;282(36):26361-8 PMID: 17609216
  47. Intracellular delivery of large molecules and small particles by cell-penetrating proteins and peptides.
    Adv Drug Deliv Rev. 2005 Feb 28;57(4):637-51 PMID: 15722168
  48. In vitro nuclear interactome of the HIV-1 Tat protein.
    Retrovirology. 2009 May 19;6:47 PMID: 19454010
  49. Pre-structured motifs in the natively unstructured preS1 surface antigen of hepatitis B virus.
    Protein Sci. 2007 Oct;16(10):2108-17 PMID: 17766372
  50. HIV-1 Vif binds to APOBEC3G mRNA and inhibits its translation.
    Nucleic Acids Res. 2010 Jan;38(2):633-46 PMID: 19910370
  51. Identification of an ion channel activity of the Vpu transmembrane domain and its involvement in the regulation of virus release from HIV-1-infected cells.
    FEBS Lett. 1996 Nov 25;398(1):12-8 PMID: 8946945
  52. Human immunodeficiency virus type 1 nucleocapsid protein specifically stimulates Mg2+-dependent DNA integration in vitro.
    J Virol. 1997 Aug;71(8):6225-9 PMID: 9223522
  53. HIV-1 accessory proteins--ensuring viral survival in a hostile environment.
    Cell Host Microbe. 2008 Jun 12;3(6):388-98 PMID: 18541215
  54. HIV-1 Tat interaction with Dicer: requirement for RNA.
    Retrovirology. 2006 Dec 20;3:95 PMID: 17181864
  55. Lower in vivo mutation rate of human immunodeficiency virus type 1 than that predicted from the fidelity of purified reverse transcriptase.
    J Virol. 1995 Aug;69(8):5087-94 PMID: 7541846
  56. Improved sequence-based prediction of disordered regions with multilayer fusion of multiple information sources.
    Bioinformatics. 2010 Sep 15;26(18):i489-96 PMID: 20823312
  57. Status of APOBEC3G/F in cells and progeny virions modulated by Vif determines HIV-1 infectivity.
    Microbes Infect. 2010 Feb;12(2):166-71 PMID: 19944180
  58. Biochemical and structural analysis of isolated mature cores of human immunodeficiency virus type 1.
    J Virol. 2000 Feb;74(3):1168-77 PMID: 10627527
  59. Human immunodeficiency virus type 1 Vif is efficiently packaged into virions during productive but not chronic infection.
    J Virol. 2003 Jan;77(2):1131-40 PMID: 12502829
  60. The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus.
    Nature. 1984 Dec 20-1985 Jan 2;312(5996):763-7 PMID: 6096719
  61. Solution structural dynamics of HIV-1 reverse transcriptase heterodimer.
    Biochemistry. 2009 Aug 18;48(32):7646-55 PMID: 19594135
  62. Mutational analysis of the cleavage sequence of the human immunodeficiency virus type 1 envelope glycoprotein precursor gp160.
    J Virol. 1989 Nov;63(11):4670-5 PMID: 2677400
  63. Intrinsic disorder is a common feature of hub proteins from four eukaryotic interactomes.
    PLoS Comput Biol. 2006 Aug 4;2(8):e100 PMID: 16884331
  64. Molecular structure and biochemical properties of the HCCH-Zn2+ site in HIV-1 Vif.
    Biochemistry. 2009 Aug 25;48(33):7969-78 PMID: 19588889
  65. DNA deamination mediates innate immunity to retroviral infection.
    Cell. 2003 Jun 13;113(6):803-9 PMID: 12809610
  66. Multiple integrase functions are required to form the native structure of the human immunodeficiency virus type I intasome.
    J Biol Chem. 1999 Jun 11;274(24):17358-64 PMID: 10358097
  67. Structural basis for targeting HIV-1 Gag proteins to the plasma membrane for virus assembly.
    Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11364-9 PMID: 16840558
  68. Subcellular localization of the Vif protein of human immunodeficiency virus type 1.
    J Virol. 1994 Feb;68(2):704-12 PMID: 8289374
  69. Predicting Protein Disorder for N-, C-, and Internal Regions.
    Genome Inform Ser Workshop Genome Inform. 1999;10:30-40 PMID: 11072340
  70. Suppression of an intrinsic strand transfer activity of HIV-1 Tat protein by its second-exon sequences.
    Virology. 2003 Mar 1;307(1):154-63 PMID: 12667823
  71. The host cell MAP kinase ERK-2 regulates viral assembly and release by phosphorylating the p6gag protein of HIV-1.
    J Biol Chem. 2004 Jul 30;279(31):32426-34 PMID: 15155723
  72. A patch of positively charged amino acids surrounding the human immunodeficiency virus type 1 Vif SLVx4Yx9Y motif influences its interaction with APOBEC3G.
    J Virol. 2009 Sep;83(17):8674-82 PMID: 19535450
  73. Tat protein of HIV-1 stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patients.
    Nature. 1990 May 3;345(6270):84-6 PMID: 2184372
  74. Disordered domains and high surface charge confer hubs with the ability to interact with multiple proteins in interaction networks.
    FEBS Lett. 2006 Apr 3;580(8):2041-5 PMID: 16542654
  75. Malleable machines in transcription regulation: the mediator complex.
    PLoS Comput Biol. 2008 Dec;4(12):e1000243 PMID: 19096501
  76. Local structural elements in the mostly unstructured transcriptional activation domain of human p53.
    J Biol Chem. 2000 Sep 22;275(38):29426-32 PMID: 10884388
  77. Human immunodeficiency virus type 1 Vpu protein is an oligomeric type I integral membrane protein.
    J Virol. 1993 Aug;67(8):5056-61 PMID: 8331740
  78. In-silico prediction of disorder content using hybrid sequence representation.
    BMC Bioinformatics. 2011 Jun 17;12:245 PMID: 21682902
  79. Nuclear RNA export.
    J Cell Sci. 2003 Feb 15;116(Pt 4):587-97 PMID: 12538759
  80. HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim.
    EMBO J. 2002 Dec 16;21(24):6801-10 PMID: 12486001
  81. HIV-1 Nef membrane association depends on charge, curvature, composition and sequence.
    Nat Chem Biol. 2010 Jan;6(1):46-53 PMID: 19935658
  82. Assembly and morphology of HIV: potential effect of structure on viral function.
    AIDS. 1991 Jun;5(6):617-37 PMID: 1652977
  83. Alpha helix-RNA major groove recognition in an HIV-1 rev peptide-RRE RNA complex.
    Science. 1996 Sep 13;273(5281):1547-51 PMID: 8703216
  84. Hydrophilic peptides derived from the transframe region of Gag-Pol inhibit the HIV-1 protease.
    Biochemistry. 1998 Feb 24;37(8):2105-10 PMID: 9485357
  85. Identification of a novel regulatory domain in Bcl-X(L) and Bcl-2.
    EMBO J. 1997 Mar 3;16(5):968-77 PMID: 9118958
  86. Identification of residues in the N-terminal acidic domain of HIV-1 Vpr essential for virion incorporation.
    Virology. 1995 Feb 20;207(1):297-302 PMID: 7871742
  87. Human immunodeficiency virus type 1 Vpu protein induces rapid degradation of CD4.
    J Virol. 1992 Dec;66(12):7193-200 PMID: 1433512
  88. Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid protein.
    Science. 1997 Oct 31;278(5339):849-53 PMID: 9346481
  89. Mutations in the highly conserved SLQYLA motif of Vif in a simian-human immunodeficiency virus result in a less pathogenic virus and are associated with G-to-A mutations in the viral genome.
    Virology. 2009 Jan 20;383(2):362-72 PMID: 19027134
  90. Nuclear export of 60s ribosomal subunits depends on Xpo1p and requires a nuclear export sequence-containing factor, Nmd3p, that associates with the large subunit protein Rpl10p.
    Mol Cell Biol. 2001 May;21(10):3405-15 PMID: 11313466
  91. Unfoldomics of human diseases: linking protein intrinsic disorder with diseases.
    BMC Genomics. 2009 Jul 07;10 Suppl 1:S7 PMID: 19594884
  92. Isolation of human immunodeficiency virus type 1 cores: retention of Vpr in the absence of p6(gag).
    J Virol. 2000 Jul;74(13):6198-202 PMID: 10846106
  93. Retrovirus variation and reverse transcription: abnormal strand transfers result in retrovirus genetic variation.
    Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):6900-3 PMID: 7688465
  94. Oligomeric modeling and electrostatic analysis of the gp120 envelope glycoprotein of human immunodeficiency virus.
    J Virol. 2000 Feb;74(4):1961-72 PMID: 10644369
  95. Expression and characterization of the integrase of bovine immunodeficiency virus.
    Virology. 2008 Feb 20;371(2):309-21 PMID: 17976681
  96. Kick-sTARting HIV-1 transcription elongation by 7SK snRNP deporTATion.
    Nat Struct Mol Biol. 2010 Aug;17(8):928-30 PMID: 20683478
  97. Replicative and cytopathic potential of HTLV-III/LAV with sor gene deletions.
    Science. 1986 Mar 28;231(4745):1549-53 PMID: 3006244
  98. Strong human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte activity in Sydney Blood Bank Cohort patients infected with nef-defective HIV type 1.
    J Virol. 1999 Jan;73(1):436-43 PMID: 9847349
  99. Uncoupling human immunodeficiency virus type 1 Gag and Pol reading frames: role of the transframe protein p6* in viral replication.
    J Virol. 2009 Jul;83(14):7210-20 PMID: 19403679
  100. Probing the structure of the HIV-1 Rev trans-activator protein by functional analysis.
    Protein Eng. 1997 Feb;10(2):103-7 PMID: 9089809
  101. Fragments of the HIV-1 Tat protein specifically bind TAR RNA.
    Science. 1990 Sep 14;249(4974):1281-5 PMID: 2205002
  102. Head-to-tail dimers and interdomain flexibility revealed by the crystal structure of HIV-1 capsid protein (p24) complexed with a monoclonal antibody Fab.
    EMBO J. 1999 Mar 1;18(5):1124-36 PMID: 10064580
  103. Vif overcomes the innate antiviral activity of APOBEC3G by promoting its degradation in the ubiquitin-proteasome pathway.
    J Biol Chem. 2004 Feb 27;279(9):7792-8 PMID: 14672928
  104. Association of human immunodeficiency virus type 1 Vif with RNA and its role in reverse transcription.
    J Virol. 2000 Oct;74(19):8938-45 PMID: 10982337
  105. Abundance of intrinsic disorder in protein associated with cardiovascular disease.
    Biochemistry. 2006 Sep 5;45(35):10448-60 PMID: 16939197
  106. Functional anthology of intrinsic disorder. 2. Cellular components, domains, technical terms, developmental processes, and coding sequence diversities correlated with long disordered regions.
    J Proteome Res. 2007 May;6(5):1899-916 PMID: 17391015
  107. The major homology region of the HIV-1 gag precursor influences membrane affinity.
    Biochemistry. 1996 Nov 12;35(45):14268-75 PMID: 8916912
  108. Role of auxiliary proteins in retroviral morphogenesis.
    Curr Top Microbiol Immunol. 1996;214:219-35 PMID: 8791729
  109. Permeability of the blood-brain barrier to HIV-1 Tat.
    Exp Neurol. 2005 May;193(1):218-27 PMID: 15817280
  110. Part II: alpha-synuclein and its molecular pathophysiological role in neurodegenerative disease.
    Neuropharmacology. 2003 Jul;45(1):14-44 PMID: 12814657
  111. Binding and susceptibility to postentry restriction factors in monkey cells are specified by distinct regions of the human immunodeficiency virus type 1 capsid.
    J Virol. 2004 May;78(10):5423-37 PMID: 15113921
  112. Retroviral integrases and their cousins.
    Curr Opin Struct Biol. 1996 Feb;6(1):76-83 PMID: 8696976
  113. Structural studies of HIV-1 Tat protein.
    J Mol Biol. 1995 Apr 7;247(4):529-35 PMID: 7723010
  114. Major glycoprotein antigens that induce antibodies in AIDS patients are encoded by HTLV-III.
    Science. 1985 May 31;228(4703):1091-4 PMID: 2986290
  115. Drug resistance mutations can effect dimer stability of HIV-1 protease at neutral pH.
    Protein Sci. 1999 Aug;8(8):1702-7 PMID: 10452615
  116. Nuclear import, virion incorporation, and cell cycle arrest/differentiation are mediated by distinct functional domains of human immunodeficiency virus type 1 Vpr.
    J Virol. 1997 Sep;71(9):6339-47 PMID: 9261351
  117. Virion incorporation of human immunodeficiency virus type-1 Vif is determined by intracellular expression level and may not be necessary for function.
    Virology. 1998 Sep 1;248(2):182-7 PMID: 9721227
  118. Human immunodeficiency virus type 1 Vpu protein regulates the formation of intracellular gp160-CD4 complexes.
    J Virol. 1992 Jan;66(1):226-34 PMID: 1727486
  119. A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA.
    Cell. 1998 Feb 20;92(4):451-62 PMID: 9491887
  120. Molecular biology and pathogenesis of animal lentivirus infections.
    Clin Microbiol Rev. 1996 Jan;9(1):100-17 PMID: 8665473
  121. Stability and proteolytic domains of Nef protein from human immunodeficiency virus (HIV) type 1.
    Eur J Biochem. 1994 Apr 15;221(2):811-9 PMID: 8174561
  122. Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business.
    Trends Genet. 2003 Apr;19(4):207-16 PMID: 12683974
  123. Identification of individual human immunodeficiency virus type 1 gp120 amino acids important for CD4 receptor binding.
    J Virol. 1990 Dec;64(12):5701-7 PMID: 2243375
  124. Human immunodeficiency virus type 1 Vpr is a positive regulator of viral transcription and infectivity in primary human macrophages.
    J Exp Med. 1998 Apr 6;187(7):1103-11 PMID: 9529326
  125. HIV-1 Vif: HIV's weapon against the cellular defense factor APOBEC3G.
    Curr HIV Res. 2005 Oct;3(4):339-44 PMID: 16250885
  126. Cyclophilin interactions with incoming human immunodeficiency virus type 1 capsids with opposing effects on infectivity in human cells.
    J Virol. 2005 Jan;79(1):176-83 PMID: 15596813
  127. Enhancement of SIV infection with soluble receptor molecules.
    Science. 1990 Mar 2;247(4946):1084-8 PMID: 2309120
  128. Intrinsic disorder and functional proteomics.
    Biophys J. 2007 Mar 1;92(5):1439-56 PMID: 17158572
  129. Intravirion processing of the human immunodeficiency virus type 1 Vif protein by the viral protease may be correlated with Vif function.
    J Virol. 2002 Sep;76(18):9112-23 PMID: 12186895
  130. The ancient Virus World and evolution of cells.
    Biol Direct. 2006 Sep 19;1:29 PMID: 16984643
  131. Human immunodeficiency virus type 1 Vif protein binds to the Pr55Gag precursor.
    J Virol. 1997 Dec;71(12):9358-65 PMID: 9371595
  132. Charged amino acid residues of human immunodeficiency virus type 1 nucleocapsid p7 protein involved in RNA packaging and infectivity.
    J Virol. 1996 Oct;70(10):6607-16 PMID: 8794295
  133. Conservation of amino-acid sequence motifs in lentivirus Vif proteins.
    Virus Genes. 1992 Jan;6(1):95-102 PMID: 1312756
  134. HIV accessory genes Vif and Vpu.
    Adv Pharmacol. 2007;55:199-232 PMID: 17586316
  135. Shattuck lecture--neurodegenerative diseases and prions.
    N Engl J Med. 2001 May 17;344(20):1516-26 PMID: 11357156
  136. Functional anthology of intrinsic disorder. 3. Ligands, post-translational modifications, and diseases associated with intrinsically disordered proteins.
    J Proteome Res. 2007 May;6(5):1917-32 PMID: 17391016
  137. Interactions between Nef and AIP1 proliferate multivesicular bodies and facilitate egress of HIV-1.
    Retrovirology. 2006 Jun 09;3:33 PMID: 16764724
  138. CDF it all: consensus prediction of intrinsically disordered proteins based on various cumulative distribution functions.
    FEBS Lett. 2009 May 6;583(9):1469-74 PMID: 19351533
  139. Prediction and functional analysis of native disorder in proteins from the three kingdoms of life.
    J Mol Biol. 2004 Mar 26;337(3):635-45 PMID: 15019783
  140. Augmentation of virus secretion by the human immunodeficiency virus type 1 Vpu protein is cell type independent and occurs in cultured human primary macrophages and lymphocytes.
    J Virol. 1995 Dec;69(12):7699-711 PMID: 7494279
  141. HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription.
    Mol Cell. 2010 May 14;38(3):428-38 PMID: 20471948
  142. Late budding domains and host proteins in enveloped virus release.
    Virology. 2006 Jan 5;344(1):55-63 PMID: 16364736
  143. Mining alpha-helix-forming molecular recognition features with cross species sequence alignments.
    Biochemistry. 2007 Nov 27;46(47):13468-77 PMID: 17973494
  144. The HIV-1 Vpu protein: a multifunctional enhancer of viral particle release.
    Microbes Infect. 2003 Sep;5(11):1029-39 PMID: 12941395
  145. Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients.
    Science. 1995 Nov 10;270(5238):988-91 PMID: 7481804
  146. Refined solution structure and backbone dynamics of HIV-1 Nef.
    Protein Sci. 1997 Jun;6(6):1248-63 PMID: 9194185
  147. The C-terminal moiety of HIV-1 Vpr induces cell death via a caspase-independent mitochondrial pathway.
    Cell Death Differ. 2002 Nov;9(11):1212-9 PMID: 12404120
  148. Endogenously expressed nef uncouples cytokine and chemokine production from membrane phenotypic maturation in dendritic cells.
    J Immunol. 2002 Oct 15;169(8):4172-82 PMID: 12370346
  149. Functional characterization of HIV-1 Nef mutants in the context of viral infection.
    Virology. 2006 Aug 1;351(2):322-39 PMID: 16684552
  150. Viral protein U counteracts a human host cell restriction that inhibits HIV-1 particle production.
    Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15154-9 PMID: 14657387
  151. Solution structure of the RNase H domain of the HIV-1 reverse transcriptase in the presence of magnesium.
    Biochemistry. 2003 Jan 28;42(3):639-50 PMID: 12534276
  152. The zinc fingers of HIV nucleocapsid protein NCp7 direct interactions with the viral regulatory protein Vpr.
    J Biol Chem. 1997 Dec 5;272(49):30753-9 PMID: 9388214
  153. The HIV-1 Rev protein.
    Annu Rev Microbiol. 1998;52:491-532 PMID: 9891806
  154. Cyclin box structure of the P-TEFb subunit cyclin T1 derived from a fusion complex with EIAV tat.
    J Mol Biol. 2007 Jul 27;370(5):826-36 PMID: 17540406
  155. A general model for the transmembrane proteins of HIV and other retroviruses.
    AIDS Res Hum Retroviruses. 1989 Aug;5(4):431-40 PMID: 2788443
  156. Importance of the proline-rich multimerization domain on the oligomerization and nucleic acid binding properties of HIV-1 Vif.
    Nucleic Acids Res. 2011 Mar;39(6):2404-15 PMID: 21076154
  157. Part of the C-terminal tail of the envelope gp41 transmembrane glycoprotein of human immunodeficiency virus type 1 is exposed on the surface of infected cells and is involved in virus-mediated cell fusion.
    J Gen Virol. 2005 Jan;86(Pt 1):131-138 PMID: 15604440
  158. Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein.
    EMBO J. 2001 Dec 17;20(24):7333-43 PMID: 11743009
  159. HIV-1 Tat potentiates TNF-induced NF-kappa B activation and cytotoxicity by altering the cellular redox state.
    EMBO J. 1995 Feb 1;14(3):546-54 PMID: 7859743
  160. Structural disorder in viral proteins.
    Protein Pept Lett. 2010 Aug;17(8):930-1 PMID: 20653563
  161. A leucine triplet repeat sequence (LXX)4 in p6gag is important for Vpr incorporation into human immunodeficiency virus type 1 particles.
    J Virol. 1995 Nov;69(11):6873-9 PMID: 7474102
  162. Crystal structure of dimeric HIV-1 capsid protein.
    Nat Struct Biol. 1996 Sep;3(9):763-70 PMID: 8784350
  163. Folding regulates autoprocessing of HIV-1 protease precursor.
    J Biol Chem. 2005 Mar 25;280(12):11369-78 PMID: 15632156
  164. Entropic switch regulates myristate exposure in the HIV-1 matrix protein.
    Proc Natl Acad Sci U S A. 2004 Jan 13;101(2):517-22 PMID: 14699046
  165. Modifications in host cell cytoskeleton structure and function mediated by intracellular HIV-1 Tat protein are greatly dependent on the second coding exon.
    Nucleic Acids Res. 2010 Jun;38(10):3287-307 PMID: 20139419
  166. The human immunodeficiency virus type 1 Vpu protein specifically binds to the cytoplasmic domain of CD4: implications for the mechanism of degradation.
    J Virol. 1995 Mar;69(3):1510-20 PMID: 7853484
  167. The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates.
    Cell. 1996 Jun 28;85(7):1135-48 PMID: 8674119
  168. Identification of a human immunodeficiency virus type 1 Tat epitope that is neuroexcitatory and neurotoxic.
    J Virol. 1996 Mar;70(3):1475-80 PMID: 8627665
  169. The two biological activities of human immunodeficiency virus type 1 Vpu protein involve two separable structural domains.
    J Virol. 1996 Feb;70(2):809-19 PMID: 8551619
  170. Intrinsic disorder and function of the HIV-1 Tat protein.
    Protein Pept Lett. 2010 Aug;17(8):999-1011 PMID: 20450479
  171. The solution structure of the amino-terminal HHCC domain of HIV-2 integrase: a three-helix bundle stabilized by zinc.
    Curr Biol. 1997 Oct 1;7(10):739-46 PMID: 9368756
  172. The human immunodeficiency virus type 1 vpr gene prevents cell proliferation during chronic infection.
    J Virol. 1995 Feb;69(2):882-8 PMID: 7815556
  173. Human immunodeficiency virus type 1 nucleocapsid protein promotes efficient strand transfer and specific viral DNA synthesis by inhibiting TAR-dependent self-priming from minus-strand strong-stop DNA.
    J Virol. 1997 Jul;71(7):5178-88 PMID: 9188585
  174. Cooperative and specific binding of Vif to the 5' region of HIV-1 genomic RNA.
    J Mol Biol. 2005 Nov 18;354(1):55-72 PMID: 16236319
  175. HIV-1 mediated immune pathogenesis: spotlight on the role of viral protein R (Vpr).
    Curr HIV Res. 2009 Mar;7(2):169-77 PMID: 19275586
  176. Core structure of gp41 from the HIV envelope glycoprotein.
    Cell. 1997 Apr 18;89(2):263-73 PMID: 9108481
  177. Assessment of disorder predictions in CASP8.
    Proteins. 2009;77 Suppl 9:210-6 PMID: 19774619
  178. Crystal structure of HIV-1 Tat complexed with human P-TEFb.
    Nature. 2010 Jun 10;465(7299):747-51 PMID: 20535204
  179. Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA.
    Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):6320-4 PMID: 7687065
  180. Myristoylation-dependent replication and assembly of human immunodeficiency virus 1.
    Proc Natl Acad Sci U S A. 1990 Jan;87(2):523-7 PMID: 2405382
  181. Solution structure of the DNA binding domain of HIV-1 integrase.
    Biochemistry. 1995 Aug 8;34(31):9826-33 PMID: 7632683
  182. HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes.
    Nature. 1998 Jan 22;391(6665):397-401 PMID: 9450757
  183. Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytes.
    Virology. 1995 Feb 1;206(2):935-44 PMID: 7531918
  184. HIV-1 encoded virus protein U (Vpu) solution structure of the 41-62 hydrophilic region containing the phosphorylated sites Ser52 and Ser56.
    Int J Biol Macromol. 2002 Mar 8;30(1):23-40 PMID: 11893391
  185. The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA.
    Nature. 2003 Jul 3;424(6944):94-8 PMID: 12808465
  186. A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif.
    Mol Cell. 1998 Mar;1(4):565-74 PMID: 9660940
  187. Solution structure of the human immunodeficiency virus type 1 p6 protein.
    J Biol Chem. 2005 Dec 30;280(52):42515-27 PMID: 16234236
  188. Three-dimensional solution structure of the 44 kDa ectodomain of SIV gp41.
    EMBO J. 1998 Aug 17;17(16):4572-84 PMID: 9707417
  189. Ubiquitination of APOBEC3 proteins by the Vif-Cullin5-ElonginB-ElonginC complex.
    Virology. 2006 Jan 20;344(2):263-6 PMID: 16303161
  190. A solution to limited genomic capacity: using adaptable binding surfaces to assemble the functional HIV Rev oligomer on RNA.
    Mol Cell. 2008 Sep 26;31(6):824-34 PMID: 18922466
  191. Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection.
    N Engl J Med. 1995 Jan 26;332(4):228-32 PMID: 7808489
  192. Particle size determinants in the human immunodeficiency virus type 1 Gag protein.
    J Virol. 1998 Jun;72(6):4667-77 PMID: 9573230
  193. Intrinsic structural disorder and sequence features of the cell cycle inhibitor p57Kip2.
    Proteins. 2002 Jan 1;46(1):1-7 PMID: 11746698
  194. Role of the C terminus Gag protein in human immunodeficiency virus type 1 virion assembly and maturation.
    J Gen Virol. 1995 Dec;76 ( Pt 12):3171-9 PMID: 8847526
  195. Human immunodeficiency virus type 1 Vif- mutant particles from restrictive cells: role of Vif in correct particle assembly and infectivity.
    J Virol. 1995 Apr;69(4):2058-67 PMID: 7884851
  196. Structural and functional studies in vitro on the p6 protein from the HIV-1 gag open reading frame.
    Biochim Biophys Acta. 1993 Sep 8;1182(2):157-61 PMID: 8357847
  197. HIV-1 Tat-mediated effects on focal adhesion assembly and permeability in brain microvascular endothelial cells.
    J Immunol. 2004 Nov 15;173(10):6228-33 PMID: 15528360
  198. What properties characterize the hub proteins of the protein-protein interaction network of Saccharomyces cerevisiae?
    Genome Biol. 2006;7(6):R45 PMID: 16780599
  199. The dimerization domain of HIV-1 viral infectivity factor Vif is required to block virion incorporation of APOBEC3G.
    Retrovirology. 2007 Nov 24;4:81 PMID: 18036235
  200. Identification of the Nef-associated kinase as p21-activated kinase 2.
    Curr Biol. 1999 Dec 2;9(23):1407-10 PMID: 10607567
  201. Influence of extended mutations of the HIV-1 transframe protein p6 on Nef-dependent viral replication and infectivity in vitro.
    Virology. 2009 Apr 25;387(1):200-10 PMID: 19269660
  202. A novel motif in HIV-1 Nef that regulates MIP-1beta chemokine release in macrophages.
    J Virol. 2010 Aug;84(16):8327-31 PMID: 20504918
  203. Structural insight into the human immunodeficiency virus Vif SOCS box and its role in human E3 ubiquitin ligase assembly.
    J Virol. 2008 Sep;82(17):8656-63 PMID: 18562529
  204. RNA-mediated displacement of an inhibitory snRNP complex activates transcription elongation.
    Nat Struct Mol Biol. 2010 Jul;17(7):815-21 PMID: 20562857
  205. The Vif and Gag proteins of human immunodeficiency virus type 1 colocalize in infected human T cells.
    J Virol. 1997 Jul;71(7):5259-67 PMID: 9188594
  206. Identification of the principal neutralizing determinant of human immunodeficiency virus type 1 as a fusion domain.
    J Virol. 1991 Jan;65(1):190-4 PMID: 1985197
  207. A conformational switch controlling HIV-1 morphogenesis.
    EMBO J. 2000 Jan 4;19(1):103-13 PMID: 10619849
  208. Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain.
    Mol Cell. 2002 Mar;9(3):575-86 PMID: 11931765
  209. NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1.
    Nat Struct Mol Biol. 2010 Nov;17(11):1367-76 PMID: 20972448
  210. Improved disorder prediction by combination of orthogonal approaches.
    PLoS One. 2009;4(2):e4433 PMID: 19209228
  211. The HIV 'A' (sor) gene product is essential for virus infectivity.
    Nature. 1987 Aug 20-26;328(6132):728-30 PMID: 2441266
  212. Determination of the structure of the nucleocapsid protein NCp7 from the human immunodeficiency virus type 1 by 1H NMR.
    EMBO J. 1992 Aug;11(8):3059-65 PMID: 1639074
  213. Human immunodeficiency virus type 1 Vpr: functions and molecular interactions.
    J Gen Virol. 2009 Aug;90(Pt 8):1795-1805 PMID: 19458171
  214. Export of importin alpha from the nucleus is mediated by a specific nuclear transport factor.
    Cell. 1997 Sep 19;90(6):1061-71 PMID: 9323134
  215. A large nucleoprotein assembly at the ends of the viral DNA mediates retroviral DNA integration.
    EMBO J. 1997 Dec 15;16(24):7511-20 PMID: 9405379
  216. Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm.
    J Mol Biol. 1999 Oct 22;293(2):321-31 PMID: 10550212
  217. Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility.
    Proc Natl Acad Sci U S A. 2010 Jan 19;107(3):1166-71 PMID: 20080564
  218. Structural basis of the association of HIV-1 matrix protein with DNA.
    PLoS One. 2010 Dec 23;5(12):e15675 PMID: 21203471
  219. Structure-based inhibitors of HIV-1 protease.
    Annu Rev Biochem. 1993;62:543-85 PMID: 8352596
  220. The hunt for HIV-1 integrase inhibitors.
    AIDS Patient Care STDS. 2006 Jul;20(7):489-501 PMID: 16839248
  221. Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions.
    Mol Cell. 1999 Jun;3(6):729-39 PMID: 10394361
  222. The N-terminal basic domain of the HIV-1 matrix protein does not contain a conventional nuclear localization sequence but is required for DNA binding and protein self-association.
    Biochemistry. 2008 Feb 19;47(7):2199-210 PMID: 18225865
  223. Human immunodeficiency virus type 1 Vif-derived peptides inhibit the viral protease and arrest virus production.
    FEBS Lett. 1998 Dec 28;441(3):419-26 PMID: 9891983
  224. The origin of viruses.
    Res Microbiol. 2009 Sep;160(7):466-72 PMID: 19647075
  225. Towards a mechanism of function of the viral ion channel Vpu from HIV-1.
    J Biomol Struct Dyn. 2007 Jun;24(6):589-96 PMID: 17508781
  226. NPS@: network protein sequence analysis.
    Trends Biochem Sci. 2000 Mar;25(3):147-50 PMID: 10694887
  227. Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein.
    Biochem Biophys Res Commun. 1984 Aug 16;122(3):1131-5 PMID: 6236805
  228. UV and X-ray structural studies of a 101-residue long Tat protein from a HIV-1 primary isolate and of its mutated, detoxified, vaccine candidate.
    Proteins. 2010 May 1;78(6):1441-56 PMID: 20034112
  229. Bundles consisting of extended transmembrane segments of Vpu from HIV-1: computer simulations and conductance measurements.
    Biochemistry. 2002 Jun 11;41(23):7359-65 PMID: 12044168
  230. Domain assembly, surface accessibility and sequence conservation in full length HIV-1 Nef.
    FEBS Lett. 2001 May 11;496(2-3):91-5 PMID: 11356189
  231. Cyclophilin A modulates the sensitivity of HIV-1 to host restriction factors.
    Nat Med. 2003 Sep;9(9):1138-43 PMID: 12897779
  232. Coiled coils in both intracellular vesicle and viral membrane fusion.
    Cell. 1998 Dec 23;95(7):871-4 PMID: 9875840
  233. Assembly and release of HIV-1 precursor Pr55gag virus-like particles from recombinant baculovirus-infected insect cells.
    Cell. 1989 Oct 6;59(1):103-12 PMID: 2676191
  234. Mutations in HIV reverse transcriptase which alter RNase H activity and decrease strand transfer efficiency are suppressed by HIV nucleocapsid protein.
    Proc Natl Acad Sci U S A. 1997 Jun 24;94(13):6700-5 PMID: 9192628
  235. Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody.
    Nature. 1998 Jun 18;393(6686):648-59 PMID: 9641677
  236. A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.
    Science. 1991 Feb 8;251(4994):675-8 PMID: 1899488
  237. Disorder and sequence repeats in hub proteins and their implications for network evolution.
    J Proteome Res. 2006 Nov;5(11):2985-95 PMID: 17081050
  238. Chromatin remodeling and modification during HIV-1 Tat-activated transcription.
    Curr HIV Res. 2003 Jul;1(3):343-62 PMID: 15046258
  239. Molecular recognition of the human coactivator CBP by the HIV-1 transcriptional activator Tat.
    Biochemistry. 2003 Feb 4;42(4):910-6 PMID: 12549909
  240. Identification of a protein encoded by the vpu gene of HIV-1.
    Nature. 1988 Aug 11;334(6182):532-4 PMID: 3043230
  241. Modulation of HIV-like particle assembly in vitro by inositol phosphates.
    Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10875-9 PMID: 11526217
  242. Functional characterization of the human immunodeficiency virus type 1 Nef acidic domain.
    J Virol. 2008 Oct;82(19):9657-67 PMID: 18653452
  243. The structural biology of HIV assembly.
    Curr Opin Struct Biol. 2008 Apr;18(2):203-17 PMID: 18406133
  244. A spring-loaded mechanism for the conformational change of influenza hemagglutinin.
    Cell. 1993 May 21;73(4):823-32 PMID: 8500173
  245. Specific and distinct determinants mediate membrane binding and lipid raft incorporation of HIV-1(SF2) Nef.
    Virology. 2006 Nov 25;355(2):175-91 PMID: 16916529
  246. Biogenesis and nuclear export of ribosomal subunits in higher eukaryotes depend on the CRM1 export pathway.
    J Cell Sci. 2003 Jun 15;116(Pt 12):2409-19 PMID: 12724356
  247. Intrinsic disorder in cell-signaling and cancer-associated proteins.
    J Mol Biol. 2002 Oct 25;323(3):573-84 PMID: 12381310
  248. Protein dynamics: dancing on an ever-changing free energy stage.
    Curr Opin Pharmacol. 2010 Dec;10(6):706-8 PMID: 20951643
  249. Biological activity of human immunodeficiency virus type 1 Vif requires membrane targeting by C-terminal basic domains.
    J Virol. 1995 Nov;69(11):7196-204 PMID: 7474141
  250. Identification of a cyclin T-binding domain in Hexim1 and biochemical analysis of its binding competition with HIV-1 Tat.
    J Biol Chem. 2005 Jul 1;280(26):24968-77 PMID: 15855166
  251. Conformational analysis of a peptide approximating the HCCH motif in HIV-1 Vif.
    Biopolymers. 2009;92(5):417-25 PMID: 19382167
  252. Endoproteolytic cleavage of gp160 is required for the activation of human immunodeficiency virus.
    Cell. 1988 Apr 8;53(1):55-67 PMID: 2450679
  253. In vitro assembly properties of human immunodeficiency virus type 1 Gag protein lacking the p6 domain.
    J Virol. 1999 Mar;73(3):2270-9 PMID: 9971810
  254. Role of HIV-1 envelope V3 loop cleavage in cell tropism.
    AIDS Res Hum Retroviruses. 1993 Oct;9(10):1007-15 PMID: 8280475
  255. Evidence for a cytopathogenicity determinant in HIV-1 Vpr.
    Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9503-8 PMID: 12093916
  256. Analysis of the viral elements required in the nuclear import of HIV-1 DNA.
    J Virol. 2010 Jan;84(2):729-39 PMID: 19889772
  257. HIV accessory proteins and surviving the host cell.
    Curr HIV/AIDS Rep. 2004 Apr;1(1):47-53 PMID: 16091223
  258. The protein trinity--linking function and disorder.
    Nat Biotechnol. 2001 Sep;19(9):805-6 PMID: 11533628
  259. Sequence complexity of disordered protein.
    Proteins. 2001 Jan 1;42(1):38-48 PMID: 11093259
  260. Human immunodeficiency virus type 1 Vif protein is an integral component of an mRNP complex of viral RNA and could be involved in the viral RNA folding and packaging process.
    J Virol. 2000 Sep;74(18):8252-61 PMID: 10954522
  261. Cooperative interaction between HIV-1 regulatory proteins Tat and Vpr modulates transcription of the viral genome.
    J Biol Chem. 2000 Nov 10;275(45):35209-14 PMID: 10931842
  262. Assembly of a rod-shaped chimera of a trimeric GCN4 zipper and the HIV-1 gp41 ectodomain expressed in Escherichia coli.
    Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6065-9 PMID: 9177169
  263. Biophysical characterization of Vpu from HIV-1 suggests a channel-pore dualism.
    Proteins. 2008 Mar;70(4):1488-97 PMID: 17910056
  264. Alzheimer's disease in Down's syndrome: clinicopathologic studies.
    Neurology. 1985 Jul;35(7):957-61 PMID: 3159974
  265. Differential requirement for conserved tryptophans in human immunodeficiency virus type 1 Vif for the selective suppression of APOBEC3G and APOBEC3F.
    J Virol. 2006 Mar;80(6):3112-5 PMID: 16501124
  266. The role of CD4 in HIV binding and entry.
    Philos Trans R Soc Lond B Biol Sci. 1993 Oct 29;342(1299):59-66 PMID: 7904348
  267. The HIV-1 Nef protein acts as a connector with sorting pathways in the Golgi and at the plasma membrane.
    Immunity. 1997 Jan;6(1):67-77 PMID: 9052838
  268. Cell surface CD4 downregulation and resistance to superinfection induced by a defective provirus of HIV-1.
    Virology. 1994 Dec;205(2):578-82 PMID: 7975260
  269. Molecular motions of human HIV-1 gp120 envelope glycoproteins.
    J Mol Model. 2008 Sep;14(9):857-70 PMID: 18594881
  270. The evolution of RNA viruses.
    Annu Rev Microbiol. 1982;36:47-73 PMID: 6756295
  271. Tat stimulates cotranscriptional capping of HIV mRNA.
    Mol Cell. 2002 Sep;10(3):585-97 PMID: 12408826
  272. HIV-1 matrix organizes as a hexamer of trimers on membranes containing phosphatidylinositol-(4,5)-bisphosphate.
    Virology. 2009 May 10;387(2):466-72 PMID: 19327811
  273. Structural studies of tau protein and Alzheimer paired helical filaments show no evidence for beta-structure.
    J Biol Chem. 1994 Sep 30;269(39):24290-7 PMID: 7929085
  274. Structure of full-length HIV-1 CA: a model for the mature capsid lattice.
    Cell. 2007 Oct 5;131(1):70-9 PMID: 17923088
  275. A minimal lentivirus Tat.
    J Virol. 1991 Dec;65(12):7012-5 PMID: 1658392
  276. Dissection of the HIV Vif interaction with human E3 ubiquitin ligase.
    J Virol. 2010 Jul;84(14):7135-9 PMID: 20463065
  277. AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding.
    Cell. 2003 Sep 19;114(6):689-99 PMID: 14505569
  278. Understanding protein non-folding.
    Biochim Biophys Acta. 2010 Jun;1804(6):1231-64 PMID: 20117254
  279. HIV-1 Tat protein alters tight junction protein expression and distribution in cultured brain endothelial cells.
    J Neurosci Res. 2003 Oct 15;74(2):255-65 PMID: 14515355
  280. The importance of intrinsic disorder for protein phosphorylation.
    Nucleic Acids Res. 2004 Feb 11;32(3):1037-49 PMID: 14960716
  281. Bacterial transposases and retroviral integrases.
    Mol Microbiol. 1995 Jan;15(1):13-23 PMID: 7752887
  282. The late-domain-containing protein p6 is the predominant phosphoprotein of human immunodeficiency virus type 1 particles.
    J Virol. 2002 Feb;76(3):1015-24 PMID: 11773377
  283. Molecular architecture of native HIV-1 gp120 trimers.
    Nature. 2008 Sep 4;455(7209):109-13 PMID: 18668044
  284. Deep penetration of an alpha-helix into a widened RNA major groove in the HIV-1 rev peptide-RNA aptamer complex.
    Nat Struct Biol. 1996 Dec;3(12):1026-33 PMID: 8946856
  285. Identification of a novel WxSLVK motif in the N terminus of human immunodeficiency virus and simian immunodeficiency virus Vif that is critical for APOBEC3G and APOBEC3F neutralization.
    J Virol. 2009 Sep;83(17):8544-52 PMID: 19535447
  286. HIV-1 Tat protein as a potential AIDS vaccine.
    Nat Med. 1996 Sep;2(9):960-4 PMID: 8782444
  287. HIV-1 Tat is a natively unfolded protein: the solution conformation and dynamics of reduced HIV-1 Tat-(1-72) by NMR spectroscopy.
    J Biol Chem. 2006 Mar 31;281(13):8347-56 PMID: 16423825
  288. Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels.
    EMBO J. 1985 Nov;4(11):2757-63 PMID: 4065091
  289. Intrinsic disorder in pathogenic and non-pathogenic microbes: discovering and analyzing the unfoldomes of early-branching eukaryotes.
    Mol Biosyst. 2008 Apr;4(4):328-40 PMID: 18354786
  290. Human immunodeficiency virus type 1 Vif binds the viral protease by interaction with its N-terminal region.
    J Gen Virol. 2002 Sep;83(Pt 9):2225-2230 PMID: 12185277
  291. Implications for viral capsid assembly from crystal structures of HIV-1 Gag(1-278) and CA(N)(133-278).
    Biochemistry. 2006 Sep 26;45(38):11257-66 PMID: 16981686
  292. Nef and the Nef-associated kinase.
    Res Virol. 1997 Jan-Feb;148(1):47-52 PMID: 9017834
  293. Integrase inhibitors to treat HIV/AIDS.
    Nat Rev Drug Discov. 2005 Mar;4(3):236-48 PMID: 15729361
  294. HIV-1, Vpr and the cell cycle.
    Curr Biol. 1996 Sep 1;6(9):1096-103 PMID: 8805364
  295. Peptides derived from HIV-1 Vif: a non-substrate based novel type of HIV-1 protease inhibitors.
    J Mol Biol. 1999 Mar 19;287(1):93-101 PMID: 10074409
  296. CRM1 is an export receptor for leucine-rich nuclear export signals.
    Cell. 1997 Sep 19;90(6):1051-60 PMID: 9323133
  297. Primate lentiviral virion infectivity factors are substrate receptors that assemble with cullin 5-E3 ligase through a HCCH motif to suppress APOBEC3G.
    Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11444-9 PMID: 16076960
  298. Structural insights into the cyclin T1-Tat-TAR RNA transcription activation complex from EIAV.
    Nat Struct Mol Biol. 2008 Dec;15(12):1287-92 PMID: 19029897
  299. Putative alpha-helical structures in the human immunodeficiency virus type 1 Vpu protein and CD4 are involved in binding and degradation of the CD4 molecule.
    J Virol. 1997 Jun;71(6):4452-60 PMID: 9151836
  300. HIV-1 replication.
    Somat Cell Mol Genet. 2001 Nov;26(1-6):13-33 PMID: 12465460
  301. Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation.
    Genes Dev. 2004 Dec 1;18(23):2861-6 PMID: 15574592
  302. Repression of MHC class I gene promoter activity by two-exon Tat of HIV.
    Science. 1993 May 28;260(5112):1320-2 PMID: 8493575
  303. Replicative function and neutralization sensitivity of envelope glycoproteins from primary and T-cell line-passaged human immunodeficiency virus type 1 isolates.
    J Virol. 1995 Jul;69(7):4413-22 PMID: 7769703
  304. Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu.
    Nature. 2008 Jan 24;451(7177):425-30 PMID: 18200009
  305. Contribution of the Gag-Pol transframe domain p6* and its coding sequence to morphogenesis and replication of human immunodeficiency virus type 1.
    Virology. 2004 Dec 5;330(1):271-83 PMID: 15527852
  306. Human immunodeficiency virus type 1 Vpu protein induces degradation of CD4 in vitro: the cytoplasmic domain of CD4 contributes to Vpu sensitivity.
    J Virol. 1993 Jul;67(7):3877-84 PMID: 8510209
  307. On the origin of NMR dipolar waves in transient helical elements of partially folded proteins.
    J Am Chem Soc. 2008 Aug 27;130(34):11266-7 PMID: 18665596
  308. The Vpu protein of human immunodeficiency virus type 1 forms cation-selective ion channels.
    J Virol. 1996 Oct;70(10):7108-15 PMID: 8794357
  309. Three-dimensional structure of the channel-forming trans-membrane domain of virus protein "u" (Vpu) from HIV-1.
    J Mol Biol. 2003 Oct 17;333(2):409-24 PMID: 14529626
  310. Nuclear targeting sequences--a consensus?
    Trends Biochem Sci. 1991 Dec;16(12):478-81 PMID: 1664152
  311. Local conformational stability of HIV-1 gp120 in unliganded and CD4-bound states as defined by amide hydrogen/deuterium exchange.
    J Virol. 2010 Oct;84(19):10311-21 PMID: 20660185
  312. CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5.
    Nature. 1996 Nov 14;384(6605):179-83 PMID: 8906795
  313. The role of human immunodeficiency virus type 1 envelope glycoproteins in virus infection.
    J Biol Chem. 1995 Oct 13;270(41):23883-6 PMID: 7592573
  314. The presence of human immunodeficiency virus type 1 Vpr correlates with a decrease in the frequency of mutations in a plasmid shuttle vector.
    J Virol. 1999 Sep;73(9):7132-7 PMID: 10438799
  315. Mutational analysis of the HIV-1 auxiliary protein Vif identifies independent domains important for the physical and functional interaction with HIV-1 reverse transcriptase.
    Nucleic Acids Res. 2009 Jun;37(11):3660-9 PMID: 19369217
  316. The challenges of eliciting neutralizing antibodies to HIV-1 and to influenza virus.
    Nat Rev Microbiol. 2008 Feb;6(2):143-55 PMID: 18197170
  317. Use of the two-hybrid system to identify cellular partners of the HIV1 Nef protein.
    Res Virol. 1997 Jan-Feb;148(1):71-3 PMID: 9017839
  318. Characterization and structural analysis of HIV-1 integrase conservation.
    AIDS Rev. 2009 Jan-Mar;11(1):17-29 PMID: 19290031
  319. The relation of polypeptide hormone structure and flexibility to receptor binding: the relevance of X-ray studies on insulins, glucagon and human placental lactogen.
    Mol Cell Biochem. 1975 Jul 31;8(1):5-20 PMID: 170505
  320. Structural similarity between the p17 matrix protein of HIV-1 and interferon-gamma.
    Nature. 1994 Aug 25;370(6491):666-8 PMID: 8065455
  321. Solution structure of the cytoplasmic domain of the human immunodeficiency virus type 1 encoded virus protein U (Vpu).
    Int J Pept Protein Res. 1996 Apr;47(4):297-310 PMID: 8738656
  322. Functional anthology of intrinsic disorder. 1. Biological processes and functions of proteins with long disordered regions.
    J Proteome Res. 2007 May;6(5):1882-98 PMID: 17391014
  323. Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor.
    Science. 1992 Jun 26;256(5065):1783-90 PMID: 1377403
  324. Slide into action: dynamic shuttling of HIV reverse transcriptase on nucleic acid substrates.
    Science. 2008 Nov 14;322(5904):1092-7 PMID: 19008444
  325. Folded monomer of HIV-1 protease.
    J Biol Chem. 2001 Dec 28;276(52):49110-6 PMID: 11598128
  326. Atomic structure of the ectodomain from HIV-1 gp41.
    Nature. 1997 May 22;387(6631):426-30 PMID: 9163431
  327. Malleable machines take shape in eukaryotic transcriptional regulation.
    Nat Chem Biol. 2008 Dec;4(12):728-37 PMID: 19008886
  328. Nuclear mRNA export: insights from virology.
    Trends Biochem Sci. 2003 Aug;28(8):419-24 PMID: 12932730
  329. Three-dimensional structure of the human immunodeficiency virus type 1 matrix protein.
    J Mol Biol. 1994 Nov 25;244(2):198-223 PMID: 7966331
  330. Do viral proteins possess unique biophysical features?
    Trends Biochem Sci. 2009 Feb;34(2):53-9 PMID: 19062293
  331. Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: a model for viral DNA binding.
    Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8233-8 PMID: 10890912
  332. Isolation of a simian immunodeficiency virus related to human immunodeficiency virus type 2 from a west African pet sooty mangabey.
    J Virol. 1991 Aug;65(8):4480-5 PMID: 1840620
  333. HIV-tat protein is a heparin-binding angiogenic growth factor.
    Oncogene. 1996 Jan 18;12(2):289-97 PMID: 8570206
  334. Role of myristoylation and N-terminal basic residues in membrane association of the human immunodeficiency virus type 1 Nef protein.
    J Gen Virol. 2006 Mar;87(Pt 3):563-571 PMID: 16476977
  335. Protein disorder and the evolution of molecular recognition: theory, predictions and observations.
    Pac Symp Biocomput. 1998;:473-84 PMID: 9697205
  336. HIV entry and its inhibition.
    Cell. 1998 May 29;93(5):681-4 PMID: 9630213
  337. HIV-1 Vpr induces defects in mitosis, cytokinesis, nuclear structure, and centrosomes.
    Mol Biol Cell. 2004 Apr;15(4):1793-801 PMID: 14767062
  338. Functional and structural characterization of synthetic HIV-1 Vpr that transduces cells, localizes to the nucleus, and induces G2 cell cycle arrest.
    J Biol Chem. 2000 Oct 13;275(41):32016-26 PMID: 10903315
  339. Human immunodeficiency virus type 1 preintegration complexes: studies of organization and composition.
    J Virol. 1997 Jul;71(7):5382-90 PMID: 9188609
  340. The amino-terminal region of Vpr from human immunodeficiency virus type 1 forms ion channels and kills neurons.
    J Virol. 1999 May;73(5):4230-8 PMID: 10196319
  341. HIV-1 tat binds TAFII250 and represses TAFII250-dependent transcription of major histocompatibility class I genes.
    Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11601-6 PMID: 9751712
  342. The SOCS-box of HIV-1 Vif interacts with ElonginBC by induced-folding to recruit its Cul5-containing ubiquitin ligase complex.
    PLoS Pathog. 2010 Jun 03;6(6):e1000925 PMID: 20532212
  343. High variability of the gag/pol transframe region among HIV-1 isolates.
    C R Acad Sci III. 1994 Feb;317(2):183-9 PMID: 7994608
  344. A protein-chameleon: conformational plasticity of alpha-synuclein, a disordered protein involved in neurodegenerative disorders.
    J Biomol Struct Dyn. 2003 Oct;21(2):211-34 PMID: 12956606
  345. Natural variation in Vif: differential impact on APOBEC3G/3F and a potential role in HIV-1 diversification.
    PLoS Pathog. 2005 Sep;1(1):e6 PMID: 16201018
  346. HIV Tat represses transcription of the beta 2-microglobulin promoter.
    Mol Immunol. 1998 Dec;35(18):1171-8 PMID: 10199391
  347. The role of Tat in HIV-1 replication: an activator and/or a suppressor?
    AIDS Rev. 2002 Jan-Mar;4(1):41-9 PMID: 11998784
  348. High-resolution proton-magnetic-resonance studies of chromatin core particles.
    Eur J Biochem. 1978 Sep 1;89(2):475-82 PMID: 710406
  349. Intrinsically disordered proteins may escape unwanted interactions via functional misfolding.
    Biochim Biophys Acta. 2011 May;1814(5):693-712 PMID: 21440685
  350. HIV-1 gag proteins: diverse functions in the virus life cycle.
    Virology. 1998 Nov 10;251(1):1-15 PMID: 9813197
  351. Protein structure protection commits gene expression patterns.
    Genome Biol. 2008;9(7):R107 PMID: 18606003
  352. NMR solution structure of the RNA-binding peptide from human immunodeficiency virus (type 1) Rev.
    Biochemistry. 1995 Jul 4;34(26):8242-9 PMID: 7599117
  353. Nmd3p is a Crm1p-dependent adapter protein for nuclear export of the large ribosomal subunit.
    J Cell Biol. 2000 Nov 27;151(5):1057-66 PMID: 11086007
  354. A region of the C-terminal tail of the gp41 envelope glycoprotein of human immunodeficiency virus type 1 contains a neutralizing epitope: evidence for its exposure on the surface of the virion.
    J Gen Virol. 2003 Mar;84(Pt 3):591-602 PMID: 12604810
  355. Human immunodeficiency virus (HIV) type 1 transframe protein can restore activity to a dimerization-deficient HIV protease variant.
    J Virol. 2003 Aug;77(15):8216-26 PMID: 12857890
  356. The carboxy-terminal domain is essential for stability and not for virion incorporation of HIV-1 Vpr into virus particles.
    Virology. 1995 Dec 20;214(2):647-52 PMID: 8553570
  357. Predicting Binding Regions within Disordered Proteins.
    Genome Inform Ser Workshop Genome Inform. 1999;10:41-50 PMID: 11072341
  358. Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease.
    Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11282-6 PMID: 8248242
  359. HIV-1: fifteen proteins and an RNA.
    Annu Rev Biochem. 1998;67:1-25 PMID: 9759480
  360. Solution structure of the N-terminal zinc binding domain of HIV-1 integrase.
    Nat Struct Biol. 1997 Jul;4(7):567-77 PMID: 9228950
  361. Structural disorder in the HIV-1 Vif protein and interaction-dependent gain of structure.
    Protein Pept Lett. 2010 Aug;17(8):988-98 PMID: 20450485
  362. Exploring the conformational space of Vpu from HIV-1: a versatile adaptable protein.
    J Comput Chem. 2008 Nov 15;29(14):2416-24 PMID: 18432615
  363. Mutations of the human immunodeficiency virus type 1 p6Gag domain result in reduced retention of Pol proteins during virus assembly.
    J Virol. 1998 Apr;72(4):3412-7 PMID: 9525672
  364. Identification of a major co-receptor for primary isolates of HIV-1.
    Nature. 1996 Jun 20;381(6584):661-6 PMID: 8649511
  365. Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling.
    J Mol Recognit. 2005 Sep-Oct;18(5):343-84 PMID: 16094605
  366. Structure of the anchor-domain of myristoylated and non-myristoylated HIV-1 Nef protein.
    J Mol Biol. 1999 May 28;289(1):123-38 PMID: 10339411
  367. The retroviral enzymes.
    Annu Rev Biochem. 1994;63:133-73 PMID: 7526778
  368. Flexible nets of malleable guardians: intrinsically disordered chaperones in neurodegenerative diseases.
    Chem Rev. 2011 Feb 9;111(2):1134-66 PMID: 21086986
  369. Membrane potential depolarization as a triggering mechanism for Vpu-mediated HIV-1 release.
    Biophys J. 2010 Sep 22;99(6):1718-25 PMID: 20858415
  370. Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex.
    Science. 2003 Nov 7;302(5647):1056-60 PMID: 14564014
  371. Coupled folding and binding with alpha-helix-forming molecular recognition elements.
    Biochemistry. 2005 Sep 20;44(37):12454-70 PMID: 16156658
  372. The mysterious unfoldome: structureless, underappreciated, yet vital part of any given proteome.
    J Biomed Biotechnol. 2010;2010:568068 PMID: 20011072
  373. The folding free-energy surface of HIV-1 protease: insights into the thermodynamic basis for resistance to inhibitors.
    J Mol Biol. 2009 Apr 10;387(4):1002-16 PMID: 19150359
  374. Quantitative conformational analysis of partially folded proteins from residual dipolar couplings: application to the molecular recognition element of Sendai virus nucleoprotein.
    J Am Chem Soc. 2008 Jun 25;130(25):8055-61 PMID: 18507376
  375. Carboxyl terminus of hVIP/mov34 is critical for HIV-1-Vpr interaction and glucocorticoid-mediated signaling.
    J Biol Chem. 2002 Dec 6;277(49):47854-60 PMID: 12237292
  376. Sequence-specific resonance assignments of the 1H-NMR spectra and structural characterization in solution of the HIV-1 transframe protein p6.
    Eur J Biochem. 1996 Apr 15;237(2):383-92 PMID: 8647076
  377. Zinc binding to the HCCH motif of HIV-1 virion infectivity factor induces a conformational change that mediates protein-protein interactions.
    Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18475-80 PMID: 17132731
  378. Length-dependent prediction of protein intrinsic disorder.
    BMC Bioinformatics. 2006 Apr 17;7:208 PMID: 16618368
  379. Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infection.
    J Exp Med. 1993 Jun 1;177(6):1561-6 PMID: 8098729
  380. Intracellular destinies: degradation, targeting, assembly, and endocytosis of HIV Gag.
    AIDS Rev. 2007 Jul-Sep;9(3):150-61 PMID: 17982940
  381. Assembly of HIV-1 Vif-Cul5 E3 ubiquitin ligase through a novel zinc-binding domain-stabilized hydrophobic interface in Vif.
    Virology. 2006 Jun 5;349(2):290-9 PMID: 16530799
  382. Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain.
    Cell. 1996 Jun 14;85(6):931-42 PMID: 8681387
  383. The structural biology of type I viral membrane fusion.
    Nat Rev Mol Cell Biol. 2003 Apr;4(4):309-19 PMID: 12671653
  384. Flexible nets. The roles of intrinsic disorder in protein interaction networks.
    FEBS J. 2005 Oct;272(20):5129-48 PMID: 16218947
  385. Operational definition of intrinsically unstructured protein sequences based on susceptibility to the 20S proteasome.
    Proteins. 2008 Mar;70(4):1357-66 PMID: 17879262
  386. Crystal structures of the trimeric human immunodeficiency virus type 1 matrix protein: implications for membrane association and assembly.
    Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):3099-104 PMID: 8610175
  387. Intrinsic protein disorder in complete genomes.
    Genome Inform Ser Workshop Genome Inform. 2000;11:161-71 PMID: 11700597
  388. Structures of HIV-1 gp120 envelope glycoproteins from laboratory-adapted and primary isolates.
    Structure. 2000 Dec 15;8(12):1329-39 PMID: 11188697
  389. Identification of 81LGxGxxIxW89 and 171EDRW174 domains from human immunodeficiency virus type 1 Vif that regulate APOBEC3G and APOBEC3F neutralizing activity.
    J Virol. 2010 Jun;84(11):5741-50 PMID: 20335268
  390. Viruses of the Archaea: a unifying view.
    Nat Rev Microbiol. 2006 Nov;4(11):837-48 PMID: 17041631
  391. Mitogen-activated protein kinase phosphorylates and regulates the HIV-1 Vif protein.
    J Biol Chem. 1998 Nov 6;273(45):29879-87 PMID: 9792705
  392. The HIV-1 Vif PPLP motif is necessary for human APOBEC3G binding and degradation.
    Virology. 2008 Jul 20;377(1):49-53 PMID: 18499212
  393. A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein.
    EMBO J. 1995 Oct 16;14(20):5006-15 PMID: 7588629
  394. HIV-1 Vif protein blocks the cytidine deaminase activity of B-cell specific AID in E. coli by a similar mechanism of action.
    Mol Immunol. 2007 Jan;44(4):583-90 PMID: 16580072
  395. MDM2 is a novel E3 ligase for HIV-1 Vif.
    Retrovirology. 2009 Jan 07;6:1 PMID: 19128510
  396. NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded.
    Biochemistry. 1996 Oct 29;35(43):13709-15 PMID: 8901511
  397. HIV-1 Vif versus the APOBEC3 cytidine deaminases: an intracellular duel between pathogen and host restriction factors.
    Mol Aspects Med. 2010 Oct;31(5):383-97 PMID: 20538015
  398. The emerging shape of the ESCRT machinery.
    Nat Rev Mol Cell Biol. 2007 May;8(5):355-68 PMID: 17450176
  399. Rates of spontaneous mutation.
    Genetics. 1998 Apr;148(4):1667-86 PMID: 9560386
  400. The capsid protein of human immunodeficiency virus: intersubunit interactions during virus assembly.
    FEBS J. 2009 Nov;276(21):6098-109 PMID: 19825044
  401. HIV-1 TAR RNA: the target of molecular interactions between the virus and its host.
    Curr HIV Res. 2005 Jan;3(1):61-71 PMID: 15638724
  402. A novel gene of HIV-1, vpu, and its 16-kilodalton product.
    Science. 1988 Sep 2;241(4870):1221-3 PMID: 3261888
  403. Activities and substrate specificity of the evolutionarily conserved central domain of retroviral integrase.
    Virology. 1995 Jan 10;206(1):448-56 PMID: 7831800
  404. Mutual functional destruction of HIV-1 Vpu and host TASK-1 channel.
    Mol Cell. 2004 Apr 23;14(2):259-67 PMID: 15099524
  405. Intrinsic disorder of Drosophila melanogaster hormone receptor 38 N-terminal domain.
    Proteins. 2011 Feb;79(2):376-92 PMID: 21064127
  406. The human immunodeficiency virus type 1-specific protein vpu is required for efficient virus maturation and release.
    J Virol. 1990 Feb;64(2):621-9 PMID: 2404139
  407. Why are "natively unfolded" proteins unstructured under physiologic conditions?
    Proteins. 2000 Nov 15;41(3):415-27 PMID: 11025552
  408. Mutations of basic amino acids of NCp7 of human immunodeficiency virus type 1 affect RNA binding in vitro.
    J Virol. 1996 Feb;70(2):771-7 PMID: 8551614
  409. Multitude of binding modes attainable by intrinsically disordered proteins: a portrait gallery of disorder-based complexes.
    Chem Soc Rev. 2011 Mar;40(3):1623-34 PMID: 21049125
  410. Virion-associated uracil DNA glycosylase-2 and apurinic/apyrimidinic endonuclease are involved in the degradation of APOBEC3G-edited nascent HIV-1 DNA.
    J Biol Chem. 2007 Apr 20;282(16):11667-75 PMID: 17272283
  411. The C-terminal domain of the HIV-1 Vif protein is natively unfolded in its unbound state.
    Protein Eng Des Sel. 2009 May;22(5):281-7 PMID: 19218568
  412. X-ray structures of the hexameric building block of the HIV capsid.
    Cell. 2009 Jun 26;137(7):1282-92 PMID: 19523676
  413. Characterization of a novel Cullin5 binding domain in HIV-1 Vif.
    J Mol Biol. 2007 Oct 26;373(3):541-50 PMID: 17869271
  414. Atomic structure of a thermostable subdomain of HIV-1 gp41.
    Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12303-8 PMID: 9356444
  415. Intrinsic disorder in proteins associated with neurodegenerative diseases.
    Front Biosci (Landmark Ed). 2009 Jun 01;14:5188-238 PMID: 19482612
  416. HIV-1 attachment: another look.
    Trends Microbiol. 1999 Apr;7(4):144-9 PMID: 10217828
  417. Solution structure of the hydrophilic region of HIV-1 encoded virus protein U (Vpu) by CD and 1H NMR spectroscopy.
    Int J Pept Protein Res. 1995 Jan;45(1):35-43 PMID: 7775007
  418. The HIV Env-mediated fusion reaction.
    Biochim Biophys Acta. 2003 Jul 11;1614(1):36-50 PMID: 12873764
  419. The C-terminal domain of the HIV-1 regulatory protein Vpr adopts an antiparallel dimeric structure in solution via its leucine-zipper-like domain.
    Biochem J. 2005 Apr 15;387(Pt 2):333-41 PMID: 15571493
  420. HIV Rev response element (RRE) directs assembly of the Rev homooligomer into discrete asymmetric complexes.
    Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12481-6 PMID: 20616058
  421. The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis.
    J Biol Chem. 2004 Nov 12;279(46):48197-204 PMID: 15331610
  422. Solution structure of the mature HIV-1 protease monomer: insight into the tertiary fold and stability of a precursor.
    J Biol Chem. 2003 Oct 31;278(44):43311-9 PMID: 12933791
  423. Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement.
    Nature. 1997 Feb 13;385(6617):650-3 PMID: 9024665
  424. Helix-loop-helix motif in HIV-1 Rev.
    Biochemistry. 1994 Mar 15;33(10):2988-96 PMID: 7510518
  425. Leucine-rich nuclear-export signals: born to be weak.
    Trends Cell Biol. 2005 Mar;15(3):121-4 PMID: 15752974
  426. Intrinsic disorder in yeast transcriptional regulatory network.
    Proteins. 2007 Aug 15;68(3):602-5 PMID: 17510967
  427. Intrinsically unstructured proteins.
    Trends Biochem Sci. 2002 Oct;27(10):527-33 PMID: 12368089
  428. Target cell cyclophilin A modulates human immunodeficiency virus type 1 infectivity.
    J Virol. 2004 Dec;78(23):12800-8 PMID: 15542632
  429. Functional regions of the envelope glycoprotein of human immunodeficiency virus type 1.
    Science. 1987 Sep 11;237(4820):1351-5 PMID: 3629244
  430. HIV-dementia, Tat-induced oxidative stress, and antioxidant therapeutic considerations.
    Brain Res Brain Res Rev. 2005 Dec 1;50(1):14-26 PMID: 15890409
  431. Intrinsic structural disorder of the C-terminal activation domain from the bZIP transcription factor Fos.
    Biochemistry. 2000 Mar 14;39(10):2708-13 PMID: 10704222
  432. Drugs for 'protein clouds': targeting intrinsically disordered transcription factors.
    Curr Opin Pharmacol. 2010 Dec;10(6):782-8 PMID: 20889377
  433. Recruitment of a protein complex containing Tat and cyclin T1 to TAR governs the species specificity of HIV-1 Tat.
    EMBO J. 1998 Dec 1;17(23):7056-65 PMID: 9843510
  434. Comparing and combining predictors of mostly disordered proteins.
    Biochemistry. 2005 Feb 15;44(6):1989-2000 PMID: 15697224
  435. Peripheral blood mononuclear cells produce normal amounts of defective Vif- human immunodeficiency virus type 1 particles which are restricted for the preretrotranscription steps.
    J Virol. 1995 Apr;69(4):2068-74 PMID: 7884852
  436. Dynamic binding orientations direct activity of HIV reverse transcriptase.
    Nature. 2008 May 8;453(7192):184-9 PMID: 18464735
  437. Structural basis for cooperative RNA binding and export complex assembly by HIV Rev.
    Nat Struct Mol Biol. 2010 Nov;17(11):1337-42 PMID: 20953181
  438. Structural biology of nucleocytoplasmic transport.
    Annu Rev Biochem. 2007;76:647-71 PMID: 17506639
  439. Protein intrinsic disorder toolbox for comparative analysis of viral proteins.
    BMC Genomics. 2008 Sep 16;9 Suppl 2:S4 PMID: 18831795
  440. HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP.
    Mol Cell. 2010 May 14;38(3):439-51 PMID: 20471949
  441. Distribution and three-dimensional structure of AIDS virus envelope spikes.
    Nature. 2006 Jun 15;441(7095):847-52 PMID: 16728975
  442. The role of Vpr in HIV-1 pathogenesis.
    Curr HIV Res. 2005 Jan;3(1):43-51 PMID: 15638722
  443. Role of capsid precursor processing and myristoylation in morphogenesis and infectivity of human immunodeficiency virus type 1.
    Proc Natl Acad Sci U S A. 1989 Aug;86(15):5781-5 PMID: 2788277
  444. Functional consequences of preorganized helical structure in the intrinsically disordered cell-cycle inhibitor p27(Kip1).
    Biochemistry. 2002 Jan 22;41(3):752-9 PMID: 11790096
  445. Phosphorylation of Vif and its role in HIV-1 replication.
    J Biol Chem. 1996 Apr 26;271(17):10121-9 PMID: 8626571
  446. Form, function, and use of retroviral gag proteins.
    AIDS. 1991 Jun;5(6):639-54 PMID: 1883539
  447. Functional role of the V1/V2 region of human immunodeficiency virus type 1 envelope glycoprotein gp120 in infection of primary macrophages and soluble CD4 neutralization.
    J Virol. 1994 Apr;68(4):2253-9 PMID: 8139010
  448. Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts.
    Nature. 2003 Jul 3;424(6944):99-103 PMID: 12808466
  449. Conformational changes induced in the human immunodeficiency virus envelope glycoprotein by soluble CD4 binding.
    J Exp Med. 1991 Aug 1;174(2):407-15 PMID: 1713252
  450. Molecular insight into the conformational dynamics of the Elongin BC complex and its interaction with HIV-1 Vif.
    J Mol Biol. 2010 Oct 8;402(5):892-904 PMID: 20728451
  451. The human immunodeficiency virus type 1 Vif protein reduces intracellular expression and inhibits packaging of APOBEC3G (CEM15), a cellular inhibitor of virus infectivity.
    J Virol. 2003 Nov;77(21):11398-407 PMID: 14557625
  452. A history of AIDS: looking back to see ahead.
    Eur J Immunol. 2007 Nov;37 Suppl 1:S94-102 PMID: 17972351
  453. HIV-1 Vif can directly inhibit apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G-mediated cytidine deamination by using a single amino acid interaction and without protein degradation.
    J Biol Chem. 2005 Mar 11;280(10):8765-75 PMID: 15611076
  454. Intracellular trafficking of HIV-1 Gag: how Gag interacts with cell membranes and makes viral particles.
    AIDS Rev. 2005 Apr-Jun;7(2):84-91 PMID: 16092502
  455. Relation of phenotype evolution of HIV-1 to envelope V2 configuration.
    Science. 1993 Jun 4;260(5113):1513-6 PMID: 8502996
  456. HIV-1 Nef dimerization is required for Nef-mediated receptor downregulation and viral replication.
    J Mol Biol. 2009 Nov 27;394(2):329-42 PMID: 19781555
  457. Thousands of proteins likely to have long disordered regions.
    Pac Symp Biocomput. 1998;:437-48 PMID: 9697202
  458. Interaction between the cytoplasmic domains of HIV-1 Vpu and CD4: role of Vpu residues involved in CD4 interaction and in vitro CD4 degradation.
    Virology. 1996 Sep 15;223(2):381-6 PMID: 8806575
  459. Intrinsic disorder in measles virus nucleocapsids.
    Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9839-44 PMID: 21613569
  460. Role of intrinsic disorder in transient interactions of hub proteins.
    Proteins. 2007 Mar 1;66(4):761-5 PMID: 17154416
  461. NMR studies of the phosphorylation motif of the HIV-1 protein Vpu bound to the F-box protein beta-TrCP.
    Biochemistry. 2003 Dec 23;42(50):14741-51 PMID: 14674748
  462. The DNA-binding domain of HIV-1 integrase has an SH3-like fold.
    Nat Struct Biol. 1995 Sep;2(9):807-10 PMID: 7552753
  463. The p6gag domain of human immunodeficiency virus type 1 is sufficient for the incorporation of Vpr into heterologous viral particles.
    J Virol. 1995 May;69(5):2759-64 PMID: 7707498
  464. The multimerization of human immunodeficiency virus type I Vif protein: a requirement for Vif function in the viral life cycle.
    J Biol Chem. 2001 Feb 16;276(7):4889-93 PMID: 11071884
  465. Protein disorder in the human diseasome: unfoldomics of human genetic diseases.
    BMC Genomics. 2009 Jul 07;10 Suppl 1:S12 PMID: 19594871
  466. HIV-1 Vif protein binds the editing enzyme APOBEC3G and induces its degradation.
    Nat Med. 2003 Nov;9(11):1398-403 PMID: 14528301
  467. TC-1 is a novel tumorigenic and natively disordered protein associated with thyroid cancer.
    Cancer Res. 2004 Apr 15;64(8):2766-73 PMID: 15087392
  468. Human immunodeficiency virus type 1 Vif protein is packaged into the nucleoprotein complex through an interaction with viral genomic RNA.
    J Virol. 2001 Aug;75(16):7252-65 PMID: 11461998
  469. Membrane binding of human immunodeficiency virus type 1 matrix protein in vivo supports a conformational myristyl switch mechanism.
    J Virol. 1997 Sep;71(9):6582-92 PMID: 9261380
  470. Correlation of the structural and functional domains in the membrane protein Vpu from HIV-1.
    Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14336-41 PMID: 10588706
  471. NMR structure of the HIV-1 regulatory protein VPR.
    J Mol Biol. 2003 Mar 14;327(1):215-27 PMID: 12614620
  472. Secondary structure and tertiary fold of the human immunodeficiency virus protein U (Vpu) cytoplasmic domain in solution.
    Eur J Biochem. 1997 May 1;245(3):581-8 PMID: 9182993
  473. Composition Profiler: a tool for discovery and visualization of amino acid composition differences.
    BMC Bioinformatics. 2007 Jun 19;8:211 PMID: 17578581
  474. Collective motions in HIV-1 reverse transcriptase: examination of flexibility and enzyme function.
    J Mol Biol. 1999 Jan 22;285(3):1023-37 PMID: 9887265
  475. HIV-1 integrase inhibitors: update and perspectives.
    Adv Pharmacol. 2008;56:199-228 PMID: 18086413
  476. Transient structure of the amyloid precursor protein cytoplasmic tail indicates preordering of structure for binding to cytosolic factors.
    Biochemistry. 2000 Mar 14;39(10):2714-25 PMID: 10704223
  477. Preformed secondary structure drives the association reaction of GCN4-p1, a model coiled-coil system.
    J Mol Biol. 2000 Mar 3;296(4):1105-16 PMID: 10686107
  478. A zinc-binding region in Vif binds Cul5 and determines cullin selection.
    J Biol Chem. 2006 Jun 23;281(25):17259-17265 PMID: 16636053
  479. Natively unfolded proteins: a point where biology waits for physics.
    Protein Sci. 2002 Apr;11(4):739-56 PMID: 11910019
  480. Requirements for the nuclear export of the small ribosomal subunit.
    J Cell Sci. 2002 Jul 15;115(Pt 14):2985-95 PMID: 12082158
  481. Intrinsically disordered protein.
    J Mol Graph Model. 2001;19(1):26-59 PMID: 11381529
  482. The HIV-1 Vif protein: a paradigm for viral:cell interactions.
    Cell Mol Life Sci. 2003 Oct;60(10):2017-9 PMID: 14618252
  483. Functional role of human immunodeficiency virus type 1 vpu.
    Proc Natl Acad Sci U S A. 1989 Jul;86(13):5163-7 PMID: 2472639
Article Info
Journal
Cellular and molecular life sciences : CMLS
Abbr.
Cell Mol Life Sci
ISSN
1420-9071
DOI
10.1007/s00018-011-0859-3
Published
2012-04-00
Epub
2011-00-28
Pages
1211-59
Language
English
Region
Switzerland
NLM ID
9705402
Subset
IM
External Links
PubMed source DOI: 10.1007/s00018-011-0859-3 View journal details
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