A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA.

3T3 Cells Amino Acid Sequence Animals Bacterial Proteins/genetics CHO Cells Cell Nucleus/enzymology Chemoreceptor Cells Cloning, Molecular Cricetinae Cyclin C Cyclin T Cyclin-Dependent Kinases/metabolism Cyclins/genetics,metabolism DNA Footprinting Escherichia coli Proteins Gene Expression Regulation, Viral/physiology Gene Products, tat/metabolism HIV-1 Humans Membrane Proteins/genetics Mice Molecular Sequence Data Nucleic Acid Conformation Positive Transcriptional Elongation Factor B Protein Serine-Threonine Kinases/metabolism RNA Polymerase II/metabolism RNA, Viral/chemistry,metabolism Receptors, Cell Surface/genetics Recombinant Proteins/genetics Ribonucleases Substrate Specificity Transcription, Genetic/physiology tat Gene Products, Human Immunodeficiency Virus

Bacterial Proteins CCNC protein, human CCNT1 protein, human Ccnc protein, mouse Ccnt1 protein, mouse Cyclin C Cyclin T Cyclins Escherichia coli Proteins Gene Products, tat Membrane Proteins RNA, Viral Receptors, Cell Surface Recombinant Proteins Tar protein, E coli tat Gene Products, Human Immunodeficiency Virus Positive Transcriptional Elongation Factor B Protein Serine-Threonine Kinases Cyclin-Dependent Kinases RNA Polymerase II Ribonucleases