Protein database searches for multiple alignments.
Protein database searches frequently can reveal biologically significant sequence relationships useful in understanding structure and function. Weak but meaningful sequence patterns can be obscured, however, by other similarities due only to chance. By searching a database for multiple as opposed to pairwise alignments, distant relationships are much more easily distinguished from background noise. Recent statistical results permit the power of this approach to be analyzed. Given a typical query sequence, an algorithm described here permits the current protein database to be searched for three-sequence alignments in less than 4 min. Such searches have revealed a variety of subtle relationships that pairwise search methods would be unable to detect.
17 references, click to expand
-
Close structural resemblance between putative polymerase of a Drosophila transposable genetic element 17.6 and pol gene product of Moloney murine leukaemia virus.EMBO J. 1985 May;4(5):1267-72 PMID: 2408886
-
Rapid and sensitive protein similarity searches.Science. 1985 Mar 22;227(4693):1435-41 PMID: 2983426
-
Nucleotide sequence of SRV-1, a type D simian acquired immune deficiency syndrome retrovirus.Science. 1986 Mar 28;231(4745):1567-72 PMID: 3006247
-
Nucleotide sequence of the CytR regulatory gene of E. coli K-12.Nucleic Acids Res. 1986 Mar 11;14(5):2215-28 PMID: 3515317
-
Amino acid sequence of human plasma alpha 1B-glycoprotein: homology to the immunoglobulin supergene family.Proc Natl Acad Sci U S A. 1986 Apr;83(8):2363-7 PMID: 3458201
-
Identification of protein sequence homology by consensus template alignment.J Mol Biol. 1986 Mar 20;188(2):233-58 PMID: 3088284
-
Profile analysis: detection of distantly related proteins.Proc Natl Acad Sci U S A. 1987 Jul;84(13):4355-8 PMID: 3474607
-
Detecting homology of distantly related proteins with consensus sequences.J Mol Biol. 1987 Dec 20;198(4):567-77 PMID: 3430622
-
Sequence of the ebgR gene of Escherichia coli: evidence that the EBG and LAC operons are descended from a common ancestor.Mol Biol Evol. 1985 Nov;2(6):478-83 PMID: 3939708
-
The immunoglobulin superfamily--domains for cell surface recognition.Annu Rev Immunol. 1988;6:381-405 PMID: 3289571
-
Automatic generation of primary sequence patterns from sets of related protein sequences.Proc Natl Acad Sci U S A. 1990 Jan;87(1):118-22 PMID: 2296575
-
Methods for assessing the statistical significance of molecular sequence features by using general scoring schemes.Proc Natl Acad Sci U S A. 1990 Mar;87(6):2264-8 PMID: 2315319
-
A general method applicable to the search for similarities in the amino acid sequence of two proteins.J Mol Biol. 1970 Mar;48(3):443-53 PMID: 5420325
-
Structural similarity in the DNA-binding domains of catabolite gene activator and cro repressor proteins.Proc Natl Acad Sci U S A. 1982 May;79(10):3097-100 PMID: 6212926
-
The nucleotide sequence of the B gene of bacteriophage Mu.Nucleic Acids Res. 1984 Nov 26;12(22):8627-38 PMID: 6095204
-
Mutational studies with the trp repressor of Escherichia coli support the helix-turn-helix model of repressor recognition of operator DNA.Proc Natl Acad Sci U S A. 1985 Jan;82(2):483-7 PMID: 3881764
-
Partition of unit-copy miniplasmids to daughter cells. III. The DNA sequence and functional organization of the P1 partition region.J Mol Biol. 1985 Sep 20;185(2):261-72 PMID: 3903163
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: product@genelibs.com
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
