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PMID: 21824527 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

The functional cycle of visual arrestins in photoreceptor cells.

Progress in retinal and eye research ·Vol. 30 ·No. 6 ·2011-11-00 ·Pages 405-30

Gurevich VV, Hanson SM, Song X, Vishnivetskiy SA, Gurevich EV

Abstract

Visual arrestin-1 plays a key role in the rapid and reproducible shutoff of rhodopsin signaling. Its highly selective binding to light-activated phosphorylated rhodopsin is an integral part of the functional perfection of rod photoreceptors. Structure-function studies revealed key elements of the sophisticated molecular mechanism ensuring arrestin-1 selectivity and paved the way to the targeted manipulation of the arrestin-1 molecule to design mutants that can compensate for congenital defects in rhodopsin phosphorylation. Arrestin-1 self-association and light-dependent translocation in photoreceptor cells work together to keep a constant supply of active rhodopsin-binding arrestin-1 monomer in the outer segment. Recent discoveries of arrestin-1 interaction with other signaling proteins suggest that it is a much more versatile signaling regulator than previously thought, affecting the function of the synaptic terminals and rod survival. Elucidation of the fine molecular mechanisms of arrestin-1 interactions with rhodopsin and other binding partners is necessary for the comprehensive understanding of rod function and for devising novel molecular tools and therapeutic approaches to the treatment of visual disorders.

MeSH Terms
Animals Arrestins/chemistry,metabolism Humans Photoreceptor Cells/metabolism Protein Transport/physiology Signal Transduction/physiology
Chemicals
Arrestins
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Gurevich Vsevolod V
Department of Pharmacology, Vanderbilt University, 2200 Pierce Ave, PRB, Rm 417D, Nashville, TN 37232, USA. vsevolod.gurevich@vanderbilt.edu
Hanson Susan M
Song Xiufeng
Vishnivetskiy Sergey A
Gurevich Eugenia V
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Article Info
Journal
Progress in retinal and eye research
Abbr.
Prog Retin Eye Res
ISSN
1873-1635
DOI
10.1016/j.preteyeres.2011.07.002
Email
vsevolod.gurevich@vanderbilt.edu
Published
2011-11-00
Epub
2011-00-29
Pages
405-30
Language
English
Region
England
NLM ID
9431859
PMCID
PMC3196764
Subset
IM
Grants
NIGMS NIH HHS · R01 GM081756-04 · United States
NIGMS NIH HHS · GM081756 · United States
NIGMS NIH HHS · R01 GM081756 · United States
NINDS NIH HHS · NS065868 · United States
NIGMS NIH HHS · R01 GM077561-04 · United States
NEI NIH HHS · EY011500 · United States
NEI NIH HHS · P30 EY008126 · United States
NINDS NIH HHS · NS045117 · United States
NIDA NIH HHS · R21 DA030103-01A1 · United States
NINDS NIH HHS · R01 NS045117 · United States
NINDS NIH HHS · R01 NS065868 · United States
NINDS NIH HHS · R01 NS065868-03 · United States
NIGMS NIH HHS · R01 GM077561 · United States
NIGMS NIH HHS · GM077561 · United States
NIDA NIH HHS · R21 DA030103 · United States
NEI NIH HHS · R01 EY011500 · United States
NEI NIH HHS · R01 EY011500-17 · United States
External Links
PubMed source DOI: 10.1016/j.preteyeres.2011.07.002 PMC Full Text View journal details
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