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PMID: 21717315 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Transcriptional regulatory elements in fungal secondary metabolism.

Journal of microbiology (Seoul, Korea) ·Vol. 49 ·No. 3 ·2011-06-00 ·Pages 329-39

Yin W, Keller NP

Abstract

Filamentous fungi produce a variety of secondary metabolites of diverse beneficial and detrimental activities to humankind. The genes required for a given secondary metabolite are typically arranged in a gene cluster. There is considerable evidence that secondary metabolite gene regulation is, in part, by transcriptional control through hierarchical levels of transcriptional regulatory elements involved in secondary metabolite cluster regulation. Identification of elements regulating secondary metabolism could potentially provide a means of increasing production of beneficial metabolites, decreasing production of detrimental metabolites, aid in the identification of 'silent' natural products and also contribute to a broader understanding of molecular mechanisms by which secondary metabolites are produced. This review summarizes regulation of secondary metabolism associated with transcriptional regulatory elements from a broad view as well as the tremendous advances in discovery of cryptic or novel secondary metabolites by genomic mining.

MeSH Terms
DNA-Binding Proteins/genetics,metabolism Fungal Proteins/genetics,metabolism Fungi/genetics,metabolism Gene Expression Regulation, Fungal Multigene Family Regulatory Elements, Transcriptional/physiology Transcription Factors/genetics,metabolism
Chemicals
DNA-Binding Proteins Fungal Proteins Transcription Factors
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Yin Wenbing
Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53706, USA.
Keller Nancy P
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Article Info
Journal
Journal of microbiology (Seoul, Korea)
Abbr.
J Microbiol
ISSN
1976-3794
DOI
10.1007/s12275-011-1009-1
Published
2011-06-00
Epub
2011-00-30
Pages
329-39
Language
English
Region
Korea (South)
NLM ID
9703165
PMCID
PMC3714018
Subset
IM
Grants
NIGMS NIH HHS · P01 GM084077 · United States
NIGMS NIH HHS · P01GM084077 · United States
External Links
PubMed source DOI: 10.1007/s12275-011-1009-1 PMC Full Text View journal details
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