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PMID: 20852771 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Mutanobactin A from the human oral pathogen Streptococcus mutans is a cross-kingdom regulator of the yeast-mycelium transition.

Organic & biomolecular chemistry ·Vol. 8 ·No. 24 ·2010-12-21 ·Pages 5486-9

Joyner PM, Liu J, Zhang Z, Merritt J, Qi F, Cichewicz RH

Abstract

The recent investigation of a gene cluster encoding for a hybrid PKS-NRPS metabolite in the oral pathogen Streptococcus mutans UA159 yielded evidence that this natural product might play an important role regulating a range of stress tolerance factors. We have now characterized the major compound generated from this gene cluster, mutanobactin A, and demonstrated that this secondary metabolite is also capable of influencing the yeast-mycelium transition of Candida albicans.

MeSH Terms
Molecular Structure Multigene Family Peptides, Cyclic/chemistry,isolation & purification Streptococcus mutans/chemistry,genetics,growth & development
Chemicals
Peptides, Cyclic mutanobactin A
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Joyner P Matthew
Natural Products Discovery Group, Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, 101 Stephenson Parkway, University of Oklahoma, Norman, OK 73019, USA.
Liu Jinman
Zhang Zhijun
Merritt Justin
Qi Fengxia
Cichewicz Robert H
References (16)
16 references, click to expand
  1. Strategies for the discovery of new natural products by genome mining.
    Chembiochem. 2009 Mar 2;10(4):625-33 PMID: 19165837
  2. Streptococcus mutans inhibits Candida albicans hyphal formation by the fatty acid signaling molecule trans-2-decenoic acid (SDSF).
    Chembiochem. 2010 Jul 26;11(11):1552-62 PMID: 20572249
  3. Marfey's reagent for chiral amino acid analysis: a review.
    Amino Acids. 2004 Dec;27(3-4):231-47 PMID: 15503232
  4. Endosymbiont-dependent host reproduction maintains bacterial-fungal mutualism.
    Curr Biol. 2007 May 1;17(9):773-7 PMID: 17412585
  5. Intercellular communication in bacteria.
    Crit Rev Microbiol. 2009;35(2):69-80 PMID: 19514909
  6. The microbes of the intestine: an introduction to their metabolic and signaling capabilities.
    Endocrinol Metab Clin North Am. 2008 Dec;37(4):857-71 PMID: 19026936
  7. Chemical sensing in mammalian host-bacterial commensal associations.
    Proc Natl Acad Sci U S A. 2010 May 25;107(21):9831-6 PMID: 20457895
  8. Inter-kingdom signaling: chemical language between bacteria and host.
    Curr Opin Microbiol. 2009 Apr;12(2):192-8 PMID: 19318290
  9. Genomic island TnSmu2 of Streptococcus mutans harbors a nonribosomal peptide synthetase-polyketide synthase gene cluster responsible for the biosynthesis of pigments involved in oxygen and H2O2 tolerance.
    Appl Environ Microbiol. 2010 Sep;76(17):5815-26 PMID: 20639370
  10. Translating metabolic exchange with imaging mass spectrometry.
    Nat Chem Biol. 2009 Dec;5(12):885-7 PMID: 19915536
  11. Metabolites from symbiotic bacteria.
    Nat Prod Rep. 2009 Mar;26(3):338-62 PMID: 19240945
  12. Inter-kingdom encounters: recent advances in molecular bacterium-fungus interactions.
    Curr Genet. 2009 Jun;55(3):233-43 PMID: 19337734
  13. Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans.
    Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14558-63 PMID: 19666480
  14. Staphylococcus aureus nonribosomal peptide secondary metabolites regulate virulence.
    Science. 2010 Jul 16;329(5989):294-6 PMID: 20522739
  15. Streptococcus mutans competence-stimulating peptide inhibits Candida albicans hypha formation.
    Eukaryot Cell. 2009 Nov;8(11):1658-64 PMID: 19717744
  16. Medically important bacterial-fungal interactions.
    Nat Rev Microbiol. 2010 May;8(5):340-9 PMID: 20348933
Article Info
Journal
Organic & biomolecular chemistry
Abbr.
Org Biomol Chem
ISSN
1477-0539
DOI
10.1039/c0ob00579g
Published
2010-12-21
Epub
2010-00-20
Pages
5486-9
Language
English
Region
England
NLM ID
101154995
PMCID
PMC2992086
Subset
IM
Grants
NIDCR NIH HHS · R01 DE018893-03 · United States
NIDCR NIH HHS · R01 DE018893 · United States
NIAID NIH HHS · R01 AI085161-01 · United States
NIAID NIH HHS · 1R01AI085161-01 · United States
NIGMS NIH HHS · R01 GM092219 · United States
NIGMS NIH HHS · R01 GM092219-01 · United States
NIAID NIH HHS · R01 AI085161 · United States
External Links
PubMed source DOI: 10.1039/c0ob00579g PMC Full Text View journal details
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