Home LiteratureArticle Details
PMID: 21594283 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Bacterial symbionts and natural products.

Chemical communications (Cambridge, England) ·Vol. 47 ·No. 27 ·2011-07-21 ·Pages 7559-66

Crawford JM, Clardy J

Abstract

The study of bacterial symbionts of eukaryotic hosts has become a powerful discovery engine for chemistry. This highlight looks at four case studies that exemplify the range of chemistry and biology involved in these symbioses: a bacterial symbiont of a fungus and a marine invertebrate that produce compounds with significant anticancer activity, and bacterial symbionts of insects and nematodes that produce compounds that regulate multilateral symbioses.

MeSH Terms
Actinobacteria/chemistry,physiology Animals Ants/microbiology,physiology Bacteria/chemistry,metabolism Bacterial Physiological Phenomena Biological Products/metabolism Coleoptera/microbiology,physiology Cyanobacteria/chemistry,physiology Fungi/physiology Invertebrates/microbiology,physiology Nematoda/microbiology,physiology Proteobacteria/chemistry,physiology Stilbenes/metabolism Symbiosis Urochordata/microbiology,physiology
Chemicals
Biological Products Stilbenes
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Crawford Jason M
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.
Clardy Jon
References (74)
74 references, click to expand
  1. Shotgun cloning and heterologous expression of the patellamide gene cluster as a strategy to achieving sustained metabolite production.
    Chembiochem. 2005 Oct;6(10):1760-5 PMID: 15988766
  2. A global assembly line for cyanobactins.
    Nat Chem Biol. 2008 Jun;4(6):341-3 PMID: 18425112
  3. Endosymbiont-dependent host reproduction maintains bacterial-fungal mutualism.
    Curr Biol. 2007 May 1;17(9):773-7 PMID: 17412585
  4. Patellamide A and C biosynthesis by a microcin-like pathway in Prochloron didemni, the cyanobacterial symbiont of Lissoclinum patella.
    Proc Natl Acad Sci U S A. 2005 May 17;102(20):7315-20 PMID: 15883371
  5. Identification of an anthraquinone pigment and a hydroxystilbene antibiotic from Xenorhabdus luminescens.
    Appl Environ Microbiol. 1988 Jun;54(6):1602-5 PMID: 3415225
  6. Mutualism and pathogenesis in Xenorhabdus and Photorhabdus: two roads to the same destination.
    Mol Microbiol. 2007 Apr;64(2):260-8 PMID: 17493120
  7. Metabolic diversity of lichen-forming ascomycetous fungi: culturing, polyketide and shikimate metabolite production, and PKS genes.
    Nat Prod Rep. 2008 Feb;25(1):188-200 PMID: 18250902
  8. Friend and foe: the two faces of Xenorhabdus nematophila.
    Nat Rev Microbiol. 2007 Aug;5(8):634-46 PMID: 17618298
  9. Skin microbiota: a source of disease or defence?
    Br J Dermatol. 2008 Mar;158(3):442-55 PMID: 18275522
  10. Infectious history.
    Science. 2000 Apr 14;288(5464):287-93 PMID: 10777411
  11. A hexA homologue from Photorhabdus regulates pathogenicity, symbiosis and phenotypic variation.
    Mol Microbiol. 2003 Mar;47(5):1445-57 PMID: 12603747
  12. A cryptic PKS-NRPS gene locus in the plant commensal Pseudomonas fluorescens Pf-5 codes for the biosynthesis of an antimitotic rhizoxin complex.
    Org Biomol Chem. 2007 Jul 21;5(14):2211-3 PMID: 17609750
  13. Structural insights into nonribosomal peptide enzymatic assembly lines.
    Nat Prod Rep. 2009 Aug;26(8):987-1000 PMID: 19636447
  14. Trading molecules and tracking targets in symbiotic interactions.
    Nat Chem Biol. 2008 Aug;4(8):466-73 PMID: 18641627
  15. Activation of TLR2 by a small molecule produced by Staphylococcus epidermidis increases antimicrobial defense against bacterial skin infections.
    J Invest Dermatol. 2010 Sep;130(9):2211-21 PMID: 20463690
  16. Metagenomic approaches to natural products from free-living and symbiotic organisms.
    Nat Prod Rep. 2009 Nov;26(11):1488-503 PMID: 19844642
  17. Regulating alternative lifestyles in entomopathogenic bacteria.
    Curr Biol. 2010 Jan 12;20(1):69-74 PMID: 20022247
  18. Isolation and identification of rhizoxin analogs from Pseudomonas fluorescens Pf-5 by using a genomic mining strategy.
    Appl Environ Microbiol. 2008 May;74(10):3085-93 PMID: 18344330
  19. Antimitotic rhizoxin derivatives from a cultured bacterial endosymbiont of the rice pathogenic fungus Rhizopus microsporus.
    J Am Chem Soc. 2006 Sep 6;128(35):11529-36 PMID: 16939276
  20. Genomics-inspired discovery of natural products.
    Curr Opin Chem Biol. 2011 Feb;15(1):22-31 PMID: 21111667
  21. Mycangimycin, a polyene peroxide from a mutualist Streptomyces sp.
    Org Lett. 2009 Feb 5;11(3):633-6 PMID: 19125624
  22. Byelyankacin: a novel melanogenesis inhibitor produced by Enterobacter sp. B20.
    J Antibiot (Tokyo). 2007 Nov;60(11):717-20 PMID: 18057703
  23. Antibiotic production in relation to bacterial growth and nematode development in Photorhabdus--Heterorhabditis infected Galleria mellonella larvae.
    FEMS Microbiol Lett. 2000 Aug 15;189(2):219-23 PMID: 10930742
  24. Has the microbiota played a critical role in the evolution of the adaptive immune system?
    Science. 2010 Dec 24;330(6012):1768-73 PMID: 21205662
  25. Staphylococcus aureus hijacks a skin commensal to intensify its virulence: immunization targeting β-hemolysin and CAMP factor.
    J Invest Dermatol. 2011 Feb;131(2):401-9 PMID: 21085191
  26. Systematic investigation of the Escherichia coli metabolome for the biosynthetic origin of an isocyanide carbon atom.
    Angew Chem Int Ed Engl. 2005 Nov 4;44(43):7045-8 PMID: 16217820
  27. Natural combinatorial peptide libraries in cyanobacterial symbionts of marine ascidians.
    Nat Chem Biol. 2006 Dec;2(12):729-35 PMID: 17086177
  28. Exploiting a global regulator for small molecule discovery in Photorhabdus luminescens.
    ACS Chem Biol. 2010 Jul 16;5(7):659-65 PMID: 20524642
  29. Polyketide-chain branching by an enzymatic Michael addition.
    Angew Chem Int Ed Engl. 2009;48(27):5001-4 PMID: 19266509
  30. Pathogenesis, parasitism and mutualism in the trophic space of microbe-plant interactions.
    Trends Microbiol. 2010 Aug;18(8):365-73 PMID: 20598545
  31. Masters of conquest and pillage: Xenorhabdus nematophila global regulators control transitions from virulence to nutrient acquisition.
    Cell Microbiol. 2009 Jul;11(7):1025-33 PMID: 19374654
  32. Pathogenic fungus harbours endosymbiotic bacteria for toxin production.
    Nature. 2005 Oct 6;437(7060):884-8 PMID: 16208371
  33. Endofungal bacteria as producers of mycotoxins.
    Trends Microbiol. 2009 Dec;17(12):570-6 PMID: 19800796
  34. Insect symbioses: a case study of past, present, and future fungus-growing ant research.
    Environ Entomol. 2009 Feb;38(1):78-92 PMID: 19791600
  35. Complete genome sequence of Burkholderia rhizoxinica, an Endosymbiont of Rhizopus microsporus.
    J Bacteriol. 2011 Feb;193(3):783-4 PMID: 21131495
  36. Evolution of host resistance in a toxin-producing bacterial-fungal alliance.
    ISME J. 2008 Jun;2(6):632-41 PMID: 18309361
  37. Photorhabdus and a host of hosts.
    Annu Rev Microbiol. 2009;63:557-74 PMID: 19575559
  38. Life in cellulose houses: symbiotic bacterial biosynthesis of ascidian drugs and drug leads.
    Curr Opin Biotechnol. 2010 Dec;21(6):827-33 PMID: 21050742
  39. Nonribosomal peptide synthetases: structures and dynamics.
    Curr Opin Struct Biol. 2010 Apr;20(2):234-40 PMID: 20153164
  40. Bacterial biosynthesis of a multipotent stilbene.
    Angew Chem Int Ed Engl. 2008;47(10):1942-5 PMID: 18236486
  41. Functionally distinct modules operate two consecutive alpha,beta-->beta,gamma double-bond shifts in the rhizoxin polyketide assembly line.
    Angew Chem Int Ed Engl. 2010 Feb 15;49(8):1460-4 PMID: 20033973
  42. How to discover new antibiotics: harvesting the parvome.
    Curr Opin Chem Biol. 2011 Feb;15(1):5-10 PMID: 21111668
  43. The biosynthetic logic of polyketide diversity.
    Angew Chem Int Ed Engl. 2009;48(26):4688-716 PMID: 19514004
  44. Burkholderia rhizoxinica sp. nov. and Burkholderia endofungorum sp. nov., bacterial endosymbionts of the plant-pathogenic fungus Rhizopus microsporus.
    Int J Syst Evol Microbiol. 2007 Nov;57(Pt 11):2583-2590 PMID: 17978222
  45. Marine drugs from sponge-microbe association--a review.
    Mar Drugs. 2010 Apr 22;8(4):1417-68 PMID: 20479984
  46. Natural products version 2.0: connecting genes to molecules.
    J Am Chem Soc. 2010 Mar 3;132(8):2469-93 PMID: 20121095
  47. Current results on biological activities of lichen secondary metabolites: a review.
    Z Naturforsch C J Biosci. 2010 Mar-Apr;65(3-4):157-73 PMID: 20469633
  48. Biomedical exploitation of the fungus-growing ant symbiosis.
    Drug News Perspect. 2010 Apr;23(3):203-10 PMID: 20440422
  49. Entomopathogenic bacteria as a source of secondary metabolites.
    Curr Opin Chem Biol. 2009 Apr;13(2):224-30 PMID: 19345136
  50. Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injury.
    Nat Med. 2009 Dec;15(12):1377-82 PMID: 19966777
  51. Uncultured microorganisms as a source of secondary metabolites.
    J Antibiot (Tokyo). 2010 Aug;63(8):468-76 PMID: 20648021
  52. They've got a ticket to ride: Xenorhabdus nematophila-Steinernema carpocapsae symbiosis.
    Curr Opin Microbiol. 2007 Jun;10(3):225-30 PMID: 17553732
  53. Natural products from isnA-containing biosynthetic gene clusters recovered from the genomes of cultured and uncultured bacteria.
    J Am Chem Soc. 2007 Oct 10;129(40):12102-3 PMID: 17880089
  54. Cloning and heterologous expression of isocyanide biosynthetic genes from environmental DNA.
    Angew Chem Int Ed Engl. 2005 Nov 4;44(43):7063-5 PMID: 16206308
  55. The regulation of pathogenicity and mutualism in Photorhabdus.
    Curr Opin Microbiol. 2006 Apr;9(2):127-32 PMID: 16480919
  56. Bacterial symbionts: prospects for the sustainable production of invertebrate-derived pharmaceuticals.
    Curr Med Chem. 2006;13(1):39-50 PMID: 16457638
  57. The final steps of bacillaene biosynthesis in Bacillus amyloliquefaciens FZB42: direct evidence for beta,gamma dehydration by a trans-acyltransferase polyketide synthase.
    Angew Chem Int Ed Engl. 2010 Feb 15;49(8):1465-7 PMID: 20087918
  58. Dentigerumycin: a bacterial mediator of an ant-fungus symbiosis.
    Nat Chem Biol. 2009 Jun;5(6):391-3 PMID: 19330011
  59. Insights into heterocyclization from two highly similar enzymes.
    J Am Chem Soc. 2010 Mar 31;132(12):4089-91 PMID: 20210311
  60. Circular logic: nonribosomal peptide-like macrocyclization with a ribosomal peptide catalyst.
    J Am Chem Soc. 2010 Nov 10;132(44):15499-501 PMID: 20961047
  61. The skin microbiome.
    Nat Rev Microbiol. 2011 Apr;9(4):244-53 PMID: 21407241
  62. An antibiotic produced by an insect-pathogenic bacterium suppresses host defenses through phenoloxidase inhibition.
    Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2419-24 PMID: 17284598
  63. Using marine natural products to discover a protease that catalyzes peptide macrocyclization of diverse substrates.
    J Am Chem Soc. 2009 Feb 18;131(6):2122-4 PMID: 19166292
  64. A gene cluster encoding rhizoxin biosynthesis in "Burkholderia rhizoxina", the bacterial endosymbiont of the fungus Rhizopus microsporus.
    Chembiochem. 2007 Jan 2;8(1):41-5 PMID: 17154220
  65. Photorhabdus: a model for the analysis of pathogenicity and mutualism.
    Cell Microbiol. 2008 Nov;10(11):2159-67 PMID: 18647173
  66. Tubulin-interactive natural products as anticancer agents.
    J Nat Prod. 2009 Mar 27;72(3):507-15 PMID: 19125622
  67. Lessons from natural molecules.
    Nature. 2004 Dec 16;432(7019):829-37 PMID: 15602548
  68. Studies on macrocyclic lactone antibiotics. VII. Structure of a phytotoxin "rhizoxin" produced by Rhizopus chinensis.
    J Antibiot (Tokyo). 1984 Apr;37(4):354-62 PMID: 6547134
  69. Selective antimicrobial action is provided by phenol-soluble modulins derived from Staphylococcus epidermidis, a normal resident of the skin.
    J Invest Dermatol. 2010 Jan;130(1):192-200 PMID: 19710683
  70. The natural history of antibiotics.
    Curr Biol. 2009 Jun 9;19(11):R437-41 PMID: 19515346
  71. Chapter 23. Cyanobactin ribosomally synthesized peptides--a case of deep metagenome mining.
    Methods Enzymol. 2009;458:575-96 PMID: 19374999
  72. Bacterial protection of beetle-fungus mutualism.
    Science. 2008 Oct 3;322(5898):63 PMID: 18832638
  73. The genome sequence of the entomopathogenic bacterium Photorhabdus luminescens.
    Nat Biotechnol. 2003 Nov;21(11):1307-13 PMID: 14528314
  74. Bacterial endophytes: recent developments and applications.
    FEMS Microbiol Lett. 2008 Jan;278(1):1-9 PMID: 18034833
Article Info
Journal
Chemical communications (Cambridge, England)
Abbr.
Chem Commun (Camb)
ISSN
1364-548X
DOI
10.1039/c1cc11574j
Published
2011-07-21
Epub
2011-00-19
Pages
7559-66
Language
English
Region
England
NLM ID
9610838
PMCID
PMC3174269
Subset
IM
Grants
NIAID NIH HHS · U54 AI057159-09 · United States
NIGMS NIH HHS · R01 GM086258 · United States
NIAID NIH HHS · U54 AI057159 · United States
NIAID NIH HHS · U54 AI057159-08 · United States
NIGMS NIH HHS · R01 GM086258-04 · United States
NIGMS NIH HHS · K99 GM097096-01 · United States
NIGMS NIH HHS · K99 GM097096-02 · United States
NIGMS NIH HHS · K99 GM097096 · United States
NIGMS NIH HHS · R00 GM097096 · United States
NIGMS NIH HHS · R01 GM086258-01 · United States
NIGMS NIH HHS · 1K99 GM097096-01 · United States
External Links
PubMed source DOI: 10.1039/c1cc11574j PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2