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PMID: 15602548 Published · ppublish English Journal Article Review

Lessons from natural molecules.

Nature ·Vol. 432 ·No. 7019 ·2004-12-16 ·Pages 829-37

Clardy J, Walsh C

Abstract

Natural products have inspired chemists and physicians for millennia. Their rich structural diversity and complexity has prompted synthetic chemists to produce them in the laboratory, often with therapeutic applications in mind, and many drugs used today are natural products or natural-product derivatives. Recent years have seen considerable advances in our understanding of natural-product biosynthesis. Coupled with improvements in approaches for natural-product isolation, characterization and synthesis, these could be opening the door to a new era in the investigation of natural products in academia and industry.

MeSH Terms
Animals Biological Factors/chemistry,isolation & purification,metabolism,pharmacology Drug Industry Humans Oxidation-Reduction Pharmaceutical Preparations/chemical synthesis,chemistry Structure-Activity Relationship
Chemicals
Biological Factors Pharmaceutical Preparations
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Clardy Jon
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA. jon_clardy@hms.harvard.edu
Walsh Christopher
Article Info
Journal
Nature
Abbr.
Nature
ISSN
1476-4687
Published
2004-12-16
Pages
829-37
Language
English
Region
England
NLM ID
0410462
Subset
IM
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