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PMID: 21541224 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The multifaceted poliovirus 2A protease: regulation of gene expression by picornavirus proteases.

Journal of biomedicine & biotechnology ·Vol. 2011 ·2011-00-00 ·Pages 369648

Castelló A, Alvarez E, Carrasco L

Abstract

After entry into animal cells, most viruses hijack essential components involved in gene expression. This is the case of poliovirus, which abrogates cellular translation soon after virus internalization. Abrogation is achieved by cleavage of both eIF4GI and eIF4GII by the viral protease 2A. Apart from the interference of poliovirus with cellular protein synthesis, other gene expression steps such as RNA and protein trafficking between nucleus and cytoplasm are also altered. Poliovirus 2A(pro) is capable of hydrolyzing components of the nuclear pore, thus preventing an efficient antiviral response by the host cell. Here, we compare in detail poliovirus 2A(pro) with other viral proteins (from picornaviruses and unrelated families) as regard to their activity on key host factors that control gene expression. It is possible that future analyses to determine the cellular proteins targeted by 2A(pro) will uncover other cellular functions ablated by poliovirus infection. Further understanding of the cellular proteins hydrolyzed by 2A(pro) will add further insight into the molecular mechanism by which poliovirus and other viruses interact with the host cell.

MeSH Terms
Cell Nucleus/metabolism Cysteine Endopeptidases/chemistry,metabolism Eukaryotic Initiation Factor-4G/metabolism Gene Expression Regulation Genome, Viral/genetics Poliovirus/enzymology,genetics Protein Biosynthesis Protein Processing, Post-Translational Structure-Activity Relationship Transcription, Genetic Viral Proteins/chemistry,metabolism
Chemicals
Eukaryotic Initiation Factor-4G Viral Proteins Cysteine Endopeptidases picornain 2A, Picornavirus
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Castelló Alfredo
European Molecular Biology Laboratory (EMBL), Heidelberg, Germany. alfredo.castello@embl.de
Alvarez Enrique
Carrasco Luis
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Article Info
Journal
Journal of biomedicine & biotechnology
Abbr.
J Biomed Biotechnol
ISSN
1110-7251
DOI
10.1155/2011/369648
Email
alfredo.castello@embl.de
Published
2011-00-00
Epub
2011-00-14
Pages
369648
Language
English
Region
United States
NLM ID
101135740
PMCID
PMC3085340
Subset
IM
External Links
PubMed source DOI: 10.1155/2011/369648 PMC Full Text
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