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PMID: 21472014 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Evidence for a core gut microbiota in the zebrafish.

The ISME journal ·Vol. 5 ·No. 10 ·2011-10-00 ·Pages 1595-608

Roeselers G, Mittge EK, Stephens WZ, Parichy DM, Cavanaugh CM, Guillemin K, Rawls JF

Abstract

Experimental analysis of gut microbial communities and their interactions with vertebrate hosts is conducted predominantly in domesticated animals that have been maintained in laboratory facilities for many generations. These animal models are useful for studying coevolved relationships between host and microbiota only if the microbial communities that occur in animals in lab facilities are representative of those that occur in nature. We performed 16S rRNA gene sequence-based comparisons of gut bacterial communities in zebrafish collected recently from their natural habitat and those reared for generations in lab facilities in different geographic locations. Patterns of gut microbiota structure in domesticated zebrafish varied across different lab facilities in correlation with historical connections between those facilities. However, gut microbiota membership in domesticated and recently caught zebrafish was strikingly similar, with a shared core gut microbiota. The zebrafish intestinal habitat therefore selects for specific bacterial taxa despite radical differences in host provenance and domestication status.

MeSH Terms
Animals Bacteria/classification,genetics,isolation & purification Gastrointestinal Tract/microbiology Intestines/microbiology Metagenome Molecular Sequence Data RNA, Bacterial/genetics RNA, Ribosomal, 16S/genetics Zebrafish/genetics,microbiology
Chemicals
RNA, Bacterial RNA, Ribosomal, 16S
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Roeselers Guus
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA.
Mittge Erika K
Stephens W Zac
Parichy David M
Cavanaugh Colleen M
Guillemin Karen
Rawls John F
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Article Info
Journal
The ISME journal
Abbr.
ISME J
ISSN
1751-7370
DOI
10.1038/ismej.2011.38
Published
2011-10-00
Epub
2011-00-07
Pages
1595-608
Language
English
Region
England
NLM ID
101301086
PMCID
PMC3176511
Subset
IM
Grants
NIEHS NIH HHS · P30 ES010126 · United States
NCRR NIH HHS · P40 RR012546 · United States
NICHD NIH HHS · HD22486 · United States
NIDDK NIH HHS · R01 DK081426 · United States
NIDDK NIH HHS · DK081426 · United States
NICHD NIH HHS · P01 HD022486 · United States
NIDDK NIH HHS · K01 DK073695 · United States
NIDDK NIH HHS · R01 DK075549 · United States
NIDDK NIH HHS · DK075549 · United States
NCRR NIH HHS · RR012546 · United States
NIDDK NIH HHS · DK073695 · United States
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PubMed source DOI: 10.1038/ismej.2011.38 PMC Full Text View journal details
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