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PMID: 212587 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Specificity of interferon action in protein synthesis.

Journal of virology ·Vol. 27 ·No. 3 ·1978-09-00 ·Pages 648-58

Yau PM, Godefroy-Colburn T, Birge CH, Ramabhadran TV, Thach RE

Abstract

Inhibitors of elongation steps in protein synthesis such as cycloheximide and anisomycin mimic interferon treatment in that they specifically inhibit the synthesis of certain viral proteins. These specific effects are seen only at very low concentrations of the antibiotics, under conditions where host cellular protein synthesis, as well as cell viability, are not severely reduced. A qualitatively as well as quantitatively close correlation between the effects of the two types of agents has been established for encephalomyocarditis virus, vesicular stomatitis virus and murine leukemia virus protein synthesis. It is concluded that one of the primary mechanisms of interferon action may be a nonspecific retardation of one or more elongation steps, and that this may be sufficient to account for its effects on the replication of certain viruses such as encephalomyocarditis and vesicular stomatitis viruses.

MeSH Terms
Anisomycin/pharmacology Cycloheximide/pharmacology Encephalomyocarditis virus/metabolism Interferons/pharmacology L Cells Leukemia Virus, Murine/metabolism Pactamycin/pharmacology Peptide Chain Elongation, Translational/drug effects Protein Biosynthesis/drug effects Vesicular stomatitis Indiana virus/metabolism Viral Proteins/biosynthesis
Chemicals
Viral Proteins Pactamycin Anisomycin Interferons Cycloheximide
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Yau P M
Godefroy-Colburn T
Birge C H
Ramabhadran T V
Thach R E
References (32)
32 references, click to expand
  1. Interferon-directed inhibition of chronic murine leukemia virus production in cell cultures: lack of effect on intracellular viral markers.
    J Virol. 1975 Sep;16(3):569-74 PMID: 51100
  2. Relationships between intracisternal type A and extracellular oncornavirus-like particles produced in murine MOPC-460 myeloma cells.
    J Virol. 1976 Apr;18(1):344-55 PMID: 56464
  3. Effect of interferon on exogenous, endogenous, and chroniv murine leukemia virus infection.
    Virology. 1976 Apr;70(2):324-38 PMID: 57667
  4. Selective blockage of initiation of host protein synthesis in RNA-virus-infected cells.
    Proc Natl Acad Sci U S A. 1975 Apr;72(4):1258-62 PMID: 165500
  5. Blocks in elongation and initiation of protein synthesis induced by interferon treatment in mouse L cells.
    Eur J Biochem. 1975 May;54(1):1-10 PMID: 168074
  6. Interferon treatment of Ehrlich ascites tumor cells: effects on exogenous mRNA translation and tRNA inactivation in the cell extract.
    J Virol. 1975 Jan;17(1):191-203 PMID: 173882
  7. Differential inhibition of vesicular stomatitis virus polypeptide synthesis by hypertonic initiation block.
    J Virol. 1975 Jan;17(1):283-6 PMID: 173890
  8. Synthesis of type C virus particles from murine-cultured cells induced by iododeoxyuridine. V. Effect of interferon and its interaction with dexamethasone.
    J Virol. 1976 Jul;19(1):108-17 PMID: 181591
  9. Competition between cellular and viral mRNAs in vitro is regulated by a messenger discriminatory initiation factor.
    Proc Natl Acad Sci U S A. 1976 Sep;73(9):3040-4 PMID: 184455
  10. Analysis of VSV mutant with attenuated cytopathogenicity: mutation in viral function, P, for inhibition of protein synthesis.
    Cell. 1977 Jun;11(2):273-81 PMID: 196757
  11. Inhibition of viral protein synthesis in monkey cells treated with interferon late in simian virus 40 lytic cycle.
    Cell. 1977 Sep;12(1):73-81 PMID: 198143
  12. Comparison of initiation rates of encephalomyocarditis virus and host protein synthesis in infected cells.
    J Virol. 1978 Sep;27(3):640-7 PMID: 212586
  13. Heterogeneity of purified mouse interferons.
    J Biol Chem. 1975 Jun 10;250(11):4139-44 PMID: 236313
  14. The effect of interferon on the formation of virus polyribosomes in L cells infected with vaccinia virus.
    J Gen Virol. 1975 May;27(2):197-209 PMID: 806660
  15. Identification of the cell multiplication inhibitory factors in interferon preparations as interferons.
    Nature. 1976 Jul 22;262(5566):300-2 PMID: 958376
  16. Antiviral and cell growth inhibitory activities reside in the same glycoprotein of human fibroblast interferon.
    Nature. 1976 Jul 22;262(5566):302-3 PMID: 958377
  17. A comparison of transfer RNA from untreated and interferon-treated murine cells.
    Virology. 1976 Oct 1;74(1):262-4 PMID: 982822
  18. Mechanism of interferon action. Studies on the mechanism of interferon-mediated inhibition of reovirus messenger RNA translation in cell-free protein synthesis systems from mouse ascites tumor cells.
    Virology. 1976 Nov;75(1):166-76 PMID: 982845
  19. Control of messenger RNA translation by minor species of leucyl-transfer RNA in extracts from interferon-treated L cells.
    J Mol Biol. 1976 Nov;108(1):43-54 PMID: 1003485
  20. Simultaneous ribosomal resistance to trichodermin and anisomycin in Saccharomyces cerevisiae mutants.
    Biochim Biophys Acta. 1975 Apr 2;383(4):427-34 PMID: 1092352
  21. The mechanism of inhibition of reovirus replication by interferon.
    Virology. 1975 Jul;66(1):229-40 PMID: 1169850
  22. Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography.
    Eur J Biochem. 1975 Aug 15;56(2):335-41 PMID: 1175627
  23. Semi-micro, dye-binding assay for rabbit interferon.
    Appl Microbiol. 1971 Apr;21(4):723-5 PMID: 4325022
  24. Simple method for the isolation of encephalomyocarditis virus ribonucleic acid.
    J Virol. 1972 Mar;9(3):559-61 PMID: 4335665
  25. Encephalomyocarditis virus infection of mouse plasmacytoma cells. I. Inhibition of cellular protein synthesis.
    J Virol. 1974 Sep;14(3):598-610 PMID: 4368674
  26. Mechanism of the interferon-induced block of mRNA translation in mouse L cells: reversal of the block by transfer RNA.
    FEBS Lett. 1974 Apr 15;41(1):125-30 PMID: 4368899
  27. Influence of interferon on virus-particle synthesis in oncornavirus-carrier lines. II. Evidence for a direct effect on particle release.
    Int J Cancer. 1974 Sep 15;14(3):335-40 PMID: 4376516
  28. Model for the regulation of mRNA translation applied to haemoglobin synthesis.
    Nature. 1974 Oct 4;251(5474):385-8 PMID: 4421673
  29. The effect of an antiviral peptide on the ribosomal reactions of the peptide elongation enzymes, EF-I and EF-II.
    Arch Biochem Biophys. 1973 Apr;155(2):278-89 PMID: 4705425
  30. Alpha and beta globin messenger ribonucleic acid. Different amounts and rates of initiation of translation.
    J Biol Chem. 1971 Dec 10;246(23):7131-8 PMID: 5167019
  31. Studies on protein and nucleic acid metabolism in virus-infected mammalian cells. 1. Encephalomyocarditis virus in Krebs II mouse-ascites-tumour cells.
    Biochem J. 1961 Sep;80:585-97 PMID: 13767335
  32. Inhibition of Protein Synthesis in Cell-Free Systems from Interferon-Treated, Infected Cells: Further Characterization and Effect of Formylmethionyl-tRNA(F).
    J Virol. 1974 Jan;13(1):9-21 PMID: 16789138
Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.27.3.648-658.1978
Published
1978-09-00
Pages
648-58
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC525853
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.27.3.648-658.1978 PMC Full Text View journal details
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