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PMID: 21245830 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Non-coding RNAs as regulators of embryogenesis.

Nature reviews. Genetics ·Vol. 12 ·No. 2 ·2011-02-00 ·Pages 136-49

Pauli A, Rinn JL, Schier AF

Abstract

Non-coding RNAs (ncRNAs) are emerging as key regulators of embryogenesis. They control embryonic gene expression by several means, ranging from microRNA-induced degradation of mRNAs to long ncRNA-mediated modification of chromatin. Many aspects of embryogenesis seem to be controlled by ncRNAs, including the maternal-zygotic transition, the maintenance of pluripotency, the patterning of the body axes, the specification and differentiation of cell types and the morphogenesis of organs. Drawing from several animal model systems, we describe two emerging themes for ncRNA function: promoting developmental transitions and maintaining developmental states. These examples also highlight the roles of ncRNAs in ensuring a robust commitment to one of two possible cell fates.

MeSH Terms
Animals Embryonic Development Embryonic Stem Cells/cytology,metabolism Gene Dosage Gene Expression Regulation Humans RNA, Messenger/genetics RNA, Untranslated/genetics
Chemicals
RNA, Messenger RNA, Untranslated
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Pauli Andrea
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA. pauli@fas.harvard.edu
Rinn John L
Schier Alexander F
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Article Info
Journal
Nature reviews. Genetics
Abbr.
Nat Rev Genet
ISSN
1471-0064
DOI
10.1038/nrg2904
Email
pauli@fas.harvard.edu
Published
2011-02-00
Pages
136-49
Language
English
Region
England
NLM ID
100962779
PMCID
PMC4081495
Subset
IM
Grants
NIGMS NIH HHS · R01 GM056211 · United States
External Links
PubMed source DOI: 10.1038/nrg2904 PMC Full Text View journal details
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