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PMID: 20864994 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Review

Small RNAs are on the move.

Nature ·Vol. 467 ·No. 7314 ·2010-09-23 ·Pages 415-9

Chitwood DH, Timmermans MC

Abstract

A key feature of RNA interference is its ability to spread from cell to cell. Such non-cell-autonomous gene silencing has been characterized extensively in both plants and animals, but the identity of the mobile silencing signal has remained elusive. Several recent studies now shed light on the identity of this signal in plants, and indicate that small RNA molecules-from short-interfering RNAs to microRNAs-are capable of moving between cells and through the vasculature. The movement of small, 21-24-nucleotide RNA species has implications for biological processes ranging from developmental patterning and stress responses to epigenetic inheritance.

MeSH Terms
Biological Transport Epigenesis, Genetic/genetics MicroRNAs/genetics,metabolism Movement Plant Cells Plants/genetics,metabolism RNA Interference RNA, Small Interfering/genetics,metabolism
Chemicals
MicroRNAs RNA, Small Interfering
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Chitwood Daniel H
Section of Plant Biology, University of California at Davis, Davis, California 95616, USA.
Timmermans Marja C P
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Article Info
Journal
Nature
Abbr.
Nature
ISSN
1476-4687
DOI
10.1038/nature09351
Published
2010-09-23
Pages
415-9
Language
English
Region
England
NLM ID
0410462
Subset
IM
External Links
PubMed source DOI: 10.1038/nature09351 View journal details
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