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PMID: 19956253 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Forcing cells to change lineages.

Nature ·Vol. 462 ·No. 7273 ·2009-12-03 ·Pages 587-94

Graf T, Enver T

Abstract

The ability to produce stem cells by induced pluripotency (iPS reprogramming) has rekindled an interest in earlier studies showing that transcription factors can directly convert specialized cells from one lineage to another. Lineage reprogramming has become a powerful tool to study cell fate choice during differentiation, akin to inducing mutations for the discovery of gene functions. The lessons learnt provide a rubric for how cells may be manipulated for therapeutic purposes.

MeSH Terms
Animals Cell Differentiation Cell Lineage/physiology Cellular Reprogramming/genetics Gene Expression Regulation, Developmental Gene Regulatory Networks/physiology Humans Pluripotent Stem Cells/cytology,metabolism Transcription Factors/metabolism
Chemicals
Transcription Factors
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Graf Thomas
Center for Genomic Regulation and ICREA, 08003 Barcelona, Spain. thomas.graf@crg.es
Enver Tariq
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Article Info
Journal
Nature
Abbr.
Nature
ISSN
1476-4687
DOI
10.1038/nature08533
Email
thomas.graf@crg.es
Published
2009-12-03
Pages
587-94
Language
English
Region
England
NLM ID
0410462
Subset
IM
Grants
Medical Research Council · MC_U137973817 · United Kingdom
External Links
PubMed source DOI: 10.1038/nature08533 View journal details
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