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PMID: 19168672 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Epigenetic reprogramming and induced pluripotency.

Development (Cambridge, England) ·Vol. 136 ·No. 4 ·2009-02-00 ·Pages 509-23

Hochedlinger K, Plath K

Abstract

The cloning of animals from adult cells has demonstrated that the developmental state of adult cells can be reprogrammed into that of embryonic cells by uncharacterized factors within the oocyte. More recently, transcription factors have been identified that can induce pluripotency in somatic cells without the use of oocytes, generating induced pluripotent stem (iPS) cells. iPS cells provide a unique platform to dissect the molecular mechanisms that underlie epigenetic reprogramming. Moreover, iPS cells can teach us about principles of normal development and disease, and might ultimately facilitate the treatment of patients by custom-tailored cell therapy.

MeSH Terms
Animals Cell Differentiation Cell Lineage Cellular Reprogramming/genetics Epigenesis, Genetic Humans Pluripotent Stem Cells/cytology,metabolism Transcription Factors/metabolism
Chemicals
Transcription Factors
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Hochedlinger Konrad
Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Boston, MA 02114, USA. khochedlinger@helix.mgh.harvard.edu
Plath Kathrin
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Article Info
Journal
Development (Cambridge, England)
Abbr.
Development
ISSN
0950-1991
DOI
10.1242/dev.020867
Email
khochedlinger@helix.mgh.harvard.edu
Published
2009-02-00
Pages
509-23
Language
English
Region
England
NLM ID
8701744
PMCID
PMC2685952
Subset
IM
External Links
PubMed source DOI: 10.1242/dev.020867 PMC Full Text View journal details
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