Home LiteratureArticle Details
PMID: 18682236 Published · ppublish English Letter Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Wnt signaling promotes reprogramming of somatic cells to pluripotency.

Cell stem cell ·Vol. 3 ·No. 2 ·2008-08-07 ·Pages 132-5

Marson A, Foreman R, Chevalier B, Bilodeau S, Kahn M, Young RA, Jaenisch R

Abstract

暂无摘要

MeSH Terms
Animals Cellular Reprogramming/genetics Gene Transfer Techniques/adverse effects Humans Kruppel-Like Factor 4 Kruppel-Like Transcription Factors/genetics Octamer Transcription Factor-3/genetics Pluripotent Stem Cells/cytology,metabolism Proto-Oncogene Proteins c-myc/genetics,metabolism Retroviridae/genetics SOXB1 Transcription Factors/genetics Signal Transduction/physiology Wnt Proteins/genetics,metabolism beta Catenin/genetics,metabolism
Chemicals
Kruppel-Like Factor 4 Kruppel-Like Transcription Factors MYC protein, human Octamer Transcription Factor-3 POU5F1 protein, human Proto-Oncogene Proteins c-myc SOX2 protein, human SOXB1 Transcription Factors Wnt Proteins beta Catenin
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Marson Alexander
Foreman Ruth
Chevalier Brett
Bilodeau Steve
Kahn Michael
Young Richard A
Jaenisch Rudolf
References (27)
27 references, click to expand
  1. Generation of germline-competent induced pluripotent stem cells.
    Nature. 2007 Jul 19;448(7151):313-7 PMID: 17554338
  2. c-Myc is dispensable for direct reprogramming of mouse fibroblasts.
    Cell Stem Cell. 2008 Jan 10;2(1):10-2 PMID: 18371415
  3. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.
    Cell. 2006 Aug 25;126(4):663-76 PMID: 16904174
  4. An extended transcriptional network for pluripotency of embryonic stem cells.
    Cell. 2008 Mar 21;132(6):1049-61 PMID: 18358816
  5. Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse.
    Cell Stem Cell. 2008 Mar 6;2(3):230-40 PMID: 18371448
  6. Why myc? An unexpected ingredient in the stem cell cocktail.
    Cell Stem Cell. 2008 Jan 10;2(1):18-21 PMID: 18371417
  7. Promoting human embryonic stem cell renewal or differentiation by modulating Wnt signal and culture conditions.
    Cell Res. 2007 Jan;17(1):62-72 PMID: 17211448
  8. Investigating Wnt signaling: a chemogenomic safari.
    Drug Discov Today. 2005 Nov 1;10(21):1467-74 PMID: 16243267
  9. Induction of pluripotent stem cells from adult human fibroblasts by defined factors.
    Cell. 2007 Nov 30;131(5):861-72 PMID: 18035408
  10. Wnt signalling in stem cells and cancer.
    Nature. 2005 Apr 14;434(7035):843-50 PMID: 15829953
  11. Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease.
    Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5856-61 PMID: 18391196
  12. T-cell factor 3 regulates embryonic stem cell pluripotency and self-renewal by the transcriptional control of multiple lineage pathways.
    Stem Cells. 2008 Aug;26(8):2019-31 PMID: 18467660
  13. Identification of c-MYC as a target of the APC pathway.
    Science. 1998 Sep 4;281(5382):1509-12 PMID: 9727977
  14. Induced pluripotent stem cell lines derived from human somatic cells.
    Science. 2007 Dec 21;318(5858):1917-20 PMID: 18029452
  15. Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells.
    Genes Dev. 2008 Mar 15;22(6):746-55 PMID: 18347094
  16. Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming.
    Cell. 2008 Feb 22;132(4):567-82 PMID: 18295576
  17. Specific inhibition of CBP/beta-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation.
    Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12171-6 PMID: 16093313
  18. Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells.
    Nat Biotechnol. 2007 Oct;25(10):1177-81 PMID: 17724450
  19. Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin.
    Science. 2007 Dec 21;318(5858):1920-3 PMID: 18063756
  20. Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts.
    Nat Biotechnol. 2008 Jan;26(1):101-6 PMID: 18059259
  21. In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state.
    Nature. 2007 Jul 19;448(7151):318-24 PMID: 17554336
  22. The ground state of embryonic stem cell self-renewal.
    Nature. 2008 May 22;453(7194):519-23 PMID: 18497825
  23. wnt3a but not wnt11 supports self-renewal of embryonic stem cells.
    Biochem Biophys Res Commun. 2006 Jun 30;345(2):789-95 PMID: 16707109
  24. Synergistic action of Wnt and LIF in maintaining pluripotency of mouse ES cells.
    Biochem Biophys Res Commun. 2006 Apr 28;343(1):159-66 PMID: 16530170
  25. Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor.
    Nat Med. 2004 Jan;10(1):55-63 PMID: 14702635
  26. Tcf3 functions as a steady-state limiter of transcriptional programs of mouse embryonic stem cell self-renewal.
    Stem Cells. 2008 Aug;26(8):1951-60 PMID: 18483421
  27. Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells.
    Cell Stem Cell. 2008 Feb 7;2(2):151-9 PMID: 18371436
Article Info
Journal
Cell stem cell
Abbr.
Cell Stem Cell
ISSN
1875-9777
Published
2008-08-07
Pages
132-5
Language
English
Region
United States
NLM ID
101311472
PMCID
PMC3235673
Subset
IM
Grants
NHGRI NIH HHS · R01 HG002668-05 · United States
NCI NIH HHS · 5-RO1-CA087869 · United States
PHS HHS · 5-RO1-HDO45022 · United States
NIGMS NIH HHS · T32 GM007753 · United States
NCI NIH HHS · 5-R37-CA084198 · United States
NCI NIH HHS · R37 CA084198 · United States
NHGRI NIH HHS · HG002668 · United States
NHGRI NIH HHS · R01 HG002668 · United States
NCI NIH HHS · R01 CA087869 · United States
Corrections
CommentIn
CommentIn
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com