Develop-WNTs in somatic cell reprogramming.

Cell stem cell ·Vol. 3 ·No. 5 ·2008-11-06 ·Pages 465-6

Merrill BJ

Abstract

Two manuscripts published recently in Cell Stem Cell (Lluis et al., 2008 [this issue]; Marson et al., 2008) show that Wnt-beta-catenin signaling stimulates nuclear reprogramming. These two studies, using distinct reprogramming methods, offer insights into the mechanisms underlying acquisition and maintenance of pluripotency.

MeSH Terms

Adult Stem Cells/cytology Animals Cell Differentiation/physiology Cell Fusion/methods Cellular Reprogramming/genetics Embryonic Stem Cells/cytology Fibroblasts/cytology Gene Expression Regulation, Developmental Gene Regulatory Networks/genetics Humans Mice Neurons/cytology Pluripotent Stem Cells/cytology,physiology Proto-Oncogene Proteins c-myc/genetics Retroviridae/genetics Transduction, Genetic/methods Wnt Proteins/metabolism beta Catenin/genetics,metabolism

Chemicals

Proto-Oncogene Proteins c-myc Wnt Proteins beta Catenin

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Merrill Bradley J

Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA. merrillb@uic.edu

Article Info

Journal

Cell stem cell

Abbr.

Cell Stem Cell

ISSN

1875-9777

DOI

10.1016/j.stem.2008.10.011

merrillb@uic.edu

Published

2008-11-06

Pages

465-6

Language

English

Region

United States

NLM ID

101311472

Subset

Corrections

CommentOn

PMID: 18682236

CommentOn

PMID: 18983965

External Links

PubMed source DOI: 10.1016/j.stem.2008.10.011 View journal details

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Develop-WNTs in somatic cell reprogramming.

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