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PMID: 11532392 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Hematopoietic development: a balancing act.

Current opinion in genetics & development ·Vol. 11 ·No. 5 ·2001-10-00 ·Pages 513-9

Cantor AB, Orkin SH

Abstract

Over the past year, significant new insights have been gained in our understanding of the lineage determination of red blood cells. In particular, evidence has emerged demonstrating that cross-antagonism of lineage-specific transcription factors plays an important role in determining cell phenotype by actively repressing alternate lineage gene programs.

MeSH Terms

Animals Carrier Proteins/metabolism Cell Differentiation Cell Lineage DNA-Binding Proteins/metabolism Erythroid-Specific DNA-Binding Factors Hematopoiesis/genetics Hematopoietic Stem Cells/cytology,metabolism Humans Nuclear Proteins/metabolism Proto-Oncogene Proteins/metabolism Trans-Activators/metabolism Transcription Factors/metabolism

Chemicals

Carrier Proteins DNA-Binding Proteins Erythroid-Specific DNA-Binding Factors Nuclear Proteins Proto-Oncogene Proteins Trans-Activators Transcription Factors ZFPM1 protein, human proto-oncogene protein Spi-1

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Cantor A B

Children's Hospital, Division of Hematology/Oncology, 300 Longwood Avenue, Boston, Massachusetts 02115, USA. alan.cantor@tch.harvard.edu

Orkin S H

Article Info

Journal

Current opinion in genetics & development

Abbr.

Curr Opin Genet Dev

ISSN

0959-437X

DOI

10.1016/s0959-437x(00)00226-4

alan.cantor@tch.harvard.edu

Published

2001-10-00

Pages

513-9

Language

English

Region

England

NLM ID

9111375

Subset

Grants

NCI NIH HHS · KO8 CA 82175-02 · United States

External Links

PubMed source DOI: 10.1016/s0959-437x(00)00226-4 View journal details

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