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PMID: 19904298 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Integrins: masters and slaves of endocytic transport.

Nature reviews. Molecular cell biology ·Vol. 10 ·No. 12 ·2009-12-00 ·Pages 843-53

Caswell PT, Vadrevu S, Norman JC

Abstract

Since it has become clear that adhesion receptors are trafficked through the endosomal pathway and that this can influence their function, much effort has been invested in obtaining detailed descriptions of the molecular machinery responsible for internalizing and recycling integrins. New findings indicate that integrin trafficking dictates the nature of Rho GTPase signalling during cytokinesis and cell migration. Furthermore, integrins can exert control over the trafficking of other receptors in a way that drives cancer cell invasion and tumour angiogenesis.

MeSH Terms
Animals Endocytosis Extracellular Matrix/metabolism Humans Integrins/metabolism Protein Transport Signal Transduction rho GTP-Binding Proteins/metabolism
Chemicals
Integrins rho GTP-Binding Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Caswell Patrick T
Beatson Institute for Cancer Research, Cancer Research UK, Glasgow, G61 3BX, Scotland.
Vadrevu Suryakiran
Norman Jim C
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Article Info
Journal
Nature reviews. Molecular cell biology
Abbr.
Nat Rev Mol Cell Biol
ISSN
1471-0080
DOI
10.1038/nrm2799
Published
2009-12-00
Pages
843-53
Language
English
Region
England
NLM ID
100962782
Subset
IM
Grants
Cancer Research UK · United Kingdom
External Links
PubMed source DOI: 10.1038/nrm2799 View journal details
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