Genomic amplicons target vesicle recycling in breast cancer.
Aberrant endocytosis, vesicle targeting, and receptor recycling represent emerging hallmarks of cancer. In this issue of the JCI, Zhang and colleagues demonstrate that RAB-coupling protein (RCP; also known as RAB11FIP1) is a "driver" of the 8p11-12 amplicon in human breast cancer and mouse xenograft models of mammary carcinogenesis (see the related article beginning on page 2171). Their finding that RAB GTPase function enables genomic amplification to confer aggressiveness to mammary tumors adds significantly to the body of evidence supporting pivotal roles for receptor trafficking in the proliferation and metastasis of cancer.
18 references, click to expand
-
GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer.Nature. 2009 Jun 25;459(7250):1085-90 PMID: 19553991
-
RCP is a human breast cancer-promoting gene with Ras-activating function.J Clin Invest. 2009 Aug;119(8):2171-83 PMID: 19620787
-
New amplified and highly expressed genes discovered in the ERBB2 amplicon in breast cancer by cDNA microarrays.Cancer Res. 2001 Nov 15;61(22):8235-40 PMID: 11719455
-
Endocytic recycling pathways: emerging regulators of cell migration.Curr Opin Cell Biol. 2006 Oct;18(5):549-57 PMID: 16904305
-
Rab-coupling protein coordinates recycling of alpha5beta1 integrin and EGFR1 to promote cell migration in 3D microenvironments.J Cell Biol. 2008 Oct 6;183(1):143-55 PMID: 18838556
-
The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers.Nat Med. 2004 Nov;10(11):1251-6 PMID: 15502842
-
Derailed endocytosis: an emerging feature of cancer.Nat Rev Cancer. 2008 Nov;8(11):835-50 PMID: 18948996
-
Loss of RAB25 expression in breast cancer.Int J Cancer. 2006 Jun 15;118(12):2957-64 PMID: 16395697
-
Disrupted RabGAP function of the p85 subunit of phosphatidylinositol 3-kinase results in cell transformation.J Biol Chem. 2008 Jun 6;283(23):15861-8 PMID: 18387942
-
Rab11a differentially modulates epidermal growth factor-induced proliferation and motility in immortal breast cells.Breast Cancer Res Treat. 2006 Nov;100(2):127-37 PMID: 16791477
-
The emerging role of the RAB25 small GTPase in cancer.Traffic. 2009 Nov;10(11):1561-8 PMID: 19719478
-
Structural basis for Rab11-mediated recruitment of FIP3 to recycling endosomes.J Mol Biol. 2006 Nov 24;364(2):121-35 PMID: 17007872
-
Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments.Dev Cell. 2007 Oct;13(4):496-510 PMID: 17925226
-
The challenge of drugging undruggable targets in cancer: lessons learned from targeting BCL-2 family members.Clin Cancer Res. 2007 Dec 15;13(24):7264-70 PMID: 18094406
-
Frequency, prognostic impact, and subtype association of 8p12, 8q24, 11q13, 12p13, 17q12, and 20q13 amplifications in breast cancers.BMC Cancer. 2006 Oct 13;6:245 PMID: 17040570
-
Genomic and transcriptional aberrations linked to breast cancer pathophysiologies.Cancer Cell. 2006 Dec;10(6):529-41 PMID: 17157792
-
Integrative genomics identifies RAB23 as an invasion mediator gene in diffuse-type gastric cancer.Cancer Res. 2008 Jun 15;68(12):4623-30 PMID: 18559507
-
Strategies for in vivo siRNA delivery in cancer.Mini Rev Med Chem. 2008 Mar;8(3):248-55 PMID: 18336345
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