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PMID: 19719478 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

The emerging role of the RAB25 small GTPase in cancer.

Traffic (Copenhagen, Denmark) ·Vol. 10 ·No. 11 ·2009-11-00 ·Pages 1561-8

Agarwal R, Jurisica I, Mills GB, Cheng KW

Abstract

RAB25, a member of the rat sarcoma (RAS) family of small GTPase, has been implicated in the pathophysiology of ovarian, breast and other cancers. Its role in endosomal transport and recycling of cell-surface receptors and signaling proteins presents a novel paradigm for the disruption of cellular pathways and promotion of tumor development and aggressiveness. Variations in structure and post-translational modifications control the localization of RAS superfamily proteins to specific subcellular compartments and recruitment of downstream effectors, allowing these small GTPases to function as sophisticated modulators of a complex and diverse range of cellular processes. Here, we review the link between RAB25 and tumor development and current knowledge regarding its possible roles in cancer.

MeSH Terms
Animals Female Humans Mammary Neoplasms, Experimental/genetics,pathology Models, Biological Monomeric GTP-Binding Proteins/genetics,metabolism Neoplasms/genetics Ovarian Neoplasms/genetics,pathology Rats rab GTP-Binding Proteins/physiology ras Proteins/physiology
Chemicals
Monomeric GTP-Binding Proteins rab GTP-Binding Proteins ras Proteins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Agarwal Roshan
Department of Systems Biology, Unit 950, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
Jurisica Igor
Mills Gordon B
Cheng Kwai Wa
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Article Info
Journal
Traffic (Copenhagen, Denmark)
Abbr.
Traffic
ISSN
1600-0854
DOI
10.1111/j.1600-0854.2009.00969.x
Published
2009-11-00
Epub
2009-00-27
Pages
1561-8
Language
English
Region
England
NLM ID
100939340
PMCID
PMC3258497
Subset
IM
Grants
NCI NIH HHS · P30CA16672 · United States
NCI NIH HHS · P30 CA016672 · United States
NCI NIH HHS · P01CA099031 · United States
NCI NIH HHS · P30 CA016672-33S1 · United States
Cancer Research UK · C2757/A5902 · United Kingdom
NCI NIH HHS · P01 CA099031 · United States
NCI NIH HHS · P50 CA098258 · United States
NCI NIH HHS · P01 CA099031-010003 · United States
External Links
PubMed source DOI: 10.1111/j.1600-0854.2009.00969.x PMC Full Text View journal details
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