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PMID: 1984666 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Comparison of the genome organization of toro- and coronaviruses: evidence for two nonhomologous RNA recombination events during Berne virus evolution.

Virology ·Vol. 180 ·No. 1 ·1991-01-00 ·Pages 448-52

Snijder EJ, den Boon JA, Horzinek MC, Spaan WJ

Abstract

Recently, toroviruses and coronaviruses have been found to be ancestrally related by divergence of their polymerase and envelope proteins from common ancestors. In addition, their genome organization and expression strategy, which involves the synthesis of a 3'-coterminal nested set of mRNAs, are comparable. Nucleotide sequence analysis of the genome of the torovirus prototype, Berne virus (BEV), has now revealed the results of two independent nonhomologous RNA recombinations during torovirus evolution. Berne virus open reading frame (ORF) 4 encodes a protein with significant sequence similarity (30-35% identical residues) to a part of the hemagglutinin esterase proteins of coronaviruses and influenza virus C. The sequence of the C-terminal part of the predicted BEV polymerase ORF1a product contains 31-36% identical amino acids when compared with the sequence of a nonstructural 30/32K coronavirus protein. The cluster of coronaviruses which contains this nonstructural gene expresses it not as a part of their polymerase, but by synthesizing an additional subgenomic mRNA.

MeSH Terms
Amino Acid Sequence Base Sequence Biological Evolution Coronaviridae/classification,genetics DNA, Viral Genes, Viral Molecular Sequence Data Open Reading Frames RNA Viruses/classification,genetics RNA, Viral/genetics Recombination, Genetic Sequence Homology, Nucleic Acid Viral Proteins/genetics
Chemicals
DNA, Viral RNA, Viral Viral Proteins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Snijder E J
Department of Virology, State University of Leiden, The Netherlands.
den Boon J A
Horzinek M C
Spaan W J
References (34)
34 references, click to expand
  1. A 3'-coterminal nested set of independently transcribed mRNAs is generated during Berne virus replication.
    J Virol. 1990 Jan;64(1):331-8 PMID: 2293666
  2. A new family of vertebrate viruses: Toroviridae.
    Intervirology. 1987;27(1):17-24 PMID: 3610570
  3. Coronaviruses: structure and genome expression.
    J Gen Virol. 1988 Dec;69 ( Pt 12):2939-52 PMID: 3058868
  4. Studies with an unclassified virus isolated from diarrheic calves.
    Vet Microbiol. 1982 Jul;7(3):221-40 PMID: 7051518
  5. Identification of a new transcriptional initiation site and the corresponding functional gene 2b in the murine coronavirus RNA genome.
    J Virol. 1989 Sep;63(9):3729-36 PMID: 2547994
  6. The sequence of cDNA of bovine coronavirus 32K nonstructural gene.
    Nucleic Acids Res. 1989 Jul 25;17(14):5847 PMID: 2762160
  7. Toroviridae: a taxonomic proposal.
    Zentralbl Veterinarmed B. 1984 Oct;31(9):649-59 PMID: 6393658
  8. Characterization of Berne virus genomic and messenger RNAs.
    J Gen Virol. 1988 Sep;69 ( Pt 9):2135-44 PMID: 3411297
  9. Morphogenesis of Berne virus (proposed family Toroviridae).
    J Gen Virol. 1986 Jul;67 ( Pt 7):1305-14 PMID: 3723110
  10. A morphological study of the replication of Breda virus (proposed family Toroviridae) in bovine intestinal cells.
    J Gen Virol. 1986 Jul;67 ( Pt 7):1293-304 PMID: 3723109
  11. Recombination between nonsegmented RNA genomes of murine coronaviruses.
    J Virol. 1985 Nov;56(2):449-56 PMID: 2997467
  12. Identification and primary structure of the gene encoding the Berne virus nucleocapsid protein.
    J Gen Virol. 1989 Dec;70 ( Pt 12):3363-70 PMID: 2607340
  13. RNAs from two independently isolated defective interfering particles of Sindbis virus contain a cellular tRNA sequence at their 5' ends.
    Proc Natl Acad Sci U S A. 1983 Jun;80(11):3279-83 PMID: 6304704
  14. Evolution of plus-strand RNA viruses.
    Intervirology. 1988;29(5):260-7 PMID: 3058643
  15. Cloning and in vitro expression of the gene for the E3 haemagglutinin glycoprotein of bovine coronavirus.
    J Gen Virol. 1989 Jan;70 ( Pt 1):155-64 PMID: 2732684
  16. Characterization of an efficient coronavirus ribosomal frameshifting signal: requirement for an RNA pseudoknot.
    Cell. 1989 May 19;57(4):537-47 PMID: 2720781
  17. Ubiquitin in a togavirus.
    Nature. 1989 Oct 12;341(6242):491 PMID: 2552321
  18. RNA recombination of murine coronaviruses: recombination between fusion-positive mouse hepatitis virus A59 and fusion-negative mouse hepatitis virus 2.
    J Virol. 1988 Jun;62(6):1989-98 PMID: 2835504
  19. The nucleocapsid of Berne virus.
    J Gen Virol. 1985 Jun;66 ( Pt 6):1287-96 PMID: 3925076
  20. High-frequency RNA recombination of murine coronaviruses.
    J Virol. 1986 Mar;57(3):729-37 PMID: 3005623
  21. Purification and partial characterization of a new enveloped RNA virus (Berne virus).
    J Gen Virol. 1983 Sep;64 (Pt 9):1849-58 PMID: 6886677
  22. The mechanism of RNA recombination in poliovirus.
    Cell. 1986 Nov 7;47(3):433-43 PMID: 3021340
  23. Structure and orientation of expressed bovine coronavirus hemagglutinin-esterase protein.
    J Virol. 1990 Apr;64(4):1834-8 PMID: 2319653
  24. Identification and stability of a 30-kDa nonstructural protein encoded by mRNA 2 of mouse hepatitis virus in infected cells.
    Virology. 1990 Mar;175(1):303-6 PMID: 2155511
  25. Primary structure and post-translational processing of the Berne virus peplomer protein.
    Virology. 1990 Oct;178(2):355-63 PMID: 2219698
  26. Western equine encephalitis virus is a recombinant virus.
    Proc Natl Acad Sci U S A. 1988 Aug;85(16):5997-6001 PMID: 3413072
  27. Increased viral pathogenicity after insertion of a 28S ribosomal RNA sequence into the haemagglutinin gene of an influenza virus.
    Nature. 1989 Jul 13;340(6229):156-7 PMID: 2544809
  28. Completion of the sequence of the genome of the coronavirus avian infectious bronchitis virus.
    J Gen Virol. 1987 Jan;68 ( Pt 1):57-77 PMID: 3027249
  29. The primary structure and expression of the second open reading frame of the polymerase gene of the coronavirus MHV-A59; a highly conserved polymerase is expressed by an efficient ribosomal frameshifting mechanism.
    Nucleic Acids Res. 1990 Apr 11;18(7):1825-32 PMID: 2159623
  30. Influenza C virus hemagglutinin: comparison with influenza A and B virus hemagglutinins.
    J Virol. 1984 Apr;50(1):118-24 PMID: 6699942
  31. In vivo RNA-RNA recombination of coronavirus in mouse brain.
    J Virol. 1988 May;62(5):1810-3 PMID: 2833625
  32. Influenza C virus esterase: analysis of catalytic site, inhibition, and possible function.
    J Virol. 1989 May;63(5):2056-62 PMID: 2495370
  33. Evolution of RNA viruses.
    Annu Rev Microbiol. 1988;42:657-83 PMID: 3060004
  34. The carboxyl-terminal part of the putative Berne virus polymerase is expressed by ribosomal frameshifting and contains sequence motifs which indicate that toro- and coronaviruses are evolutionarily related.
    Nucleic Acids Res. 1990 Aug 11;18(15):4535-42 PMID: 2388833
Article Info
Journal
Virology
Abbr.
Virology
ISSN
0042-6822
DOI
10.1016/0042-6822(91)90056-h
Published
1991-01-00
Pages
448-52
Language
English
Region
United States
NLM ID
0110674
PMCID
PMC7126633
Subset
IM
Databases
GENBANK
M34093, M76239, M76240, M76241, M76242, M76243, M76244, M86931, S70464, X52375
External Links
PubMed source DOI: 10.1016/0042-6822(91)90056-h PMC Full Text View journal details
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