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PMID: 18341986 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Genetic dissection of neural circuits.

Neuron ·Vol. 57 ·No. 5 ·2008-03-13 ·Pages 634-60

Luo L, Callaway EM, Svoboda K

Abstract

Understanding the principles of information processing in neural circuits requires systematic characterization of the participating cell types and their connections, and the ability to measure and perturb their activity. Genetic approaches promise to bring experimental access to complex neural systems, including genetic stalwarts such as the fly and mouse, but also to nongenetic systems such as primates. Together with anatomical and physiological methods, cell-type-specific expression of protein markers and sensors and transducers will be critical to construct circuit diagrams and to measure the activity of genetically defined neurons. Inactivation and activation of genetically defined cell types will establish causal relationships between activity in specific groups of neurons, circuit function, and animal behavior. Genetic analysis thus promises to reveal the logic of the neural circuits in complex brains that guide behaviors. Here we review progress in the genetic analysis of neural circuits and discuss directions for future research and development.

MeSH Terms
Animals Gene Expression Regulation/genetics,physiology Humans Nerve Net/physiology Neural Pathways/physiology Neurons/physiology
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Luo Liqun
Department of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Callaway Edward M
Svoboda Karel
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Article Info
Journal
Neuron
Abbr.
Neuron
ISSN
1097-4199
DOI
10.1016/j.neuron.2008.01.002
Published
2008-03-13
Pages
634-60
Language
English
Region
United States
NLM ID
8809320
PMCID
PMC2628815
Subset
IM
Grants
NEI NIH HHS · R01 EY010742-16 · United States
Howard Hughes Medical Institute · United States
NEI NIH HHS · R01 EY010742 · United States
NIMH NIH HHS · R01 MH063912 · United States
NIMH NIH HHS · R01 MH063912-08 · United States
External Links
PubMed source DOI: 10.1016/j.neuron.2008.01.002 PMC Full Text View journal details
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