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PMID: 17360644 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases.

Bischof J, Maeda RK, Hediger M, Karch F, Basler K

Abstract

Germ-line transformation via transposable elements is a powerful tool to study gene function in Drosophila melanogaster. However, some inherent characteristics of transposon-mediated transgenesis limit its use for transgene analysis. Here, we circumvent these limitations by optimizing a phiC31-based integration system. We generated a collection of lines with precisely mapped attP sites that allow the insertion of transgenes into many different predetermined intergenic locations throughout the fly genome. By using regulatory elements of the nanos and vasa genes, we established endogenous sources of the phiC31 integrase, eliminating the difficulties of coinjecting integrase mRNA and raising the transformation efficiency. Moreover, to discriminate between specific and rare nonspecific integration events, a white gene-based reconstitution system was generated that enables visual selection for precise attP targeting. Finally, we demonstrate that our chromosomal attP sites can be modified in situ, extending their scope while retaining their properties as landing sites. The efficiency, ease-of-use, and versatility obtained here with the phiC31-based integration system represents an important advance in transgenesis and opens up the possibility of systematic, high-throughput screening of large cDNA sets and regulatory elements.

MeSH Terms
Animals Attachment Sites, Microbiological/genetics Base Sequence Computational Biology Cytogenetic Analysis Drosophila melanogaster/genetics Gene Targeting/methods Gene Transfer Techniques Integrases/genetics Molecular Sequence Data Polymerase Chain Reaction Sequence Analysis, DNA Transformation, Genetic/genetics Transgenes/genetics Virus Integration/genetics
Chemicals
Integrases
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Bischof Johannes
Frontiers in Genetics, National Center of Competence in Research, Institute of Molecular Biology, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
Maeda Robert K
Hediger Monika
Karch François
Basler Konrad
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
Published
2007-02-27
Epub
2007-00-22
Pages
3312-7
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC1805588
Subset
IM
Databases
GENBANK
EF362407, EF362408, EF362409
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