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PMID: 16537428 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Wiring optimization can relate neuronal structure and function.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 103 ·No. 12 ·2006-03-21 ·Pages 4723-8

Chen BL, Hall DH, Chklovskii DB

Abstract

We pursue the hypothesis that neuronal placement in animals minimizes wiring costs for given functional constraints, as specified by synaptic connectivity. Using a newly compiled version of the Caenorhabditis elegans wiring diagram, we solve for the optimal layout of 279 nonpharyngeal neurons. In the optimal layout, most neurons are located close to their actual positions, suggesting that wiring minimization is an important factor. Yet some neurons exhibit strong deviations from "optimal" position. We propose that biological factors relating to axonal guidance and command neuron functions contribute to these deviations. We capture these factors by proposing a modified wiring cost function.

MeSH Terms
Animals Caenorhabditis elegans/cytology,physiology Models, Neurological Neurons/cytology,physiology,ultrastructure Synapses/physiology
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Chen Beth L
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. chenb@cshl.edu
Hall David H
Chklovskii Dmitri B
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.0506806103
Email
chenb@cshl.edu
Published
2006-03-21
Epub
2006-00-14
Pages
4723-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC1550972
Subset
IM
Grants
NIH HHS · R24 OD010943 · United States
NCRR NIH HHS · R24 RR012596 · United States
NIMH NIH HHS · MH 68938 · United States
NCRR NIH HHS · RR 12596 · United States
External Links
PubMed source DOI: 10.1073/pnas.0506806103 PMC Full Text View journal details
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