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PMID: 17466567 Published · ppublish English Journal Article Review

CD36: implications in cardiovascular disease.

The international journal of biochemistry & cell biology ·Vol. 39 ·No. 11 ·2007-00-00 ·Pages 2012-30

Febbraio M, Silverstein RL

Abstract

CD36 is a broadly expressed membrane glycoprotein that acts as a facilitator of fatty acid uptake, a signaling molecule, and a receptor for a wide range of ligands, including apoptotic cells, modified forms of low density lipoprotein, thrombospondins, fibrillar beta-amyloid, components of Gram positive bacterial walls and malaria infected erythrocytes. CD36 expression on macrophages, dendritic and endothelial cells, and in tissues including muscle, heart, and fat, suggest diverse roles, and indeed, this is truly a multi-functional receptor involved in both homeostatic and pathological conditions. Despite an impressive increase in our knowledge of CD36 functions, in depth understanding of the mechanistic aspects of this protein remains elusive. This review focuses on CD36 in cardiovascular disease-what we know, and what we have yet to learn.

MeSH Terms
Animals CD36 Antigens/chemistry,genetics,metabolism Cardiovascular Diseases/metabolism Humans Insulin Resistance/physiology
Chemicals
CD36 Antigens
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Febbraio Maria
Cleveland Clinic, Lerner Research Institute, Department of Cell Biology, NC-10, 9500 Euclid Avenue, Cleveland, OH 44195, United States. febbram@ccf.org
Silverstein Roy L
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Article Info
Journal
The international journal of biochemistry & cell biology
Abbr.
Int J Biochem Cell Biol
ISSN
1357-2725
DOI
10.1016/j.biocel.2007.03.012
Email
febbram@ccf.org
Published
2007-00-00
Epub
2007-00-23
Pages
2012-30
Language
English
Region
Netherlands
NLM ID
9508482
PMCID
PMC2034445
Subset
IM
Grants
NHLBI NIH HHS · R01 HL070083 · United States
NHLBI NIH HHS · R01 HL070083-01 · United States
External Links
PubMed source DOI: 10.1016/j.biocel.2007.03.012 PMC Full Text View journal details
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