Pattern recognition receptors: doubling up for the innate immune response.

Cell ·Vol. 111 ·No. 7 ·2002-12-27 ·Pages 927-30

Gordon S

Abstract

Antigen presenting cells (macrophages and dendritic cells) express pattern recognition molecules that are thought to recognize foreign ligands during early phases of the immune response. The best known of these are probably the Toll-like receptors, but a number of other receptors are also involved. Several of these recognize endogenous as well as exogenous ligands, suggesting that they play a dual role in normal tissue function and host defense.

MeSH Terms

Animals Antigen Presentation/immunology Dendritic Cells/immunology Drosophila Proteins Humans Lectins, C-Type Macrophage-1 Antigen/immunology Macrophages/immunology Mannose Receptor Mannose-Binding Lectins Membrane Glycoproteins/immunology Membrane Proteins/immunology Nerve Tissue Proteins/immunology Receptors, Cell Surface/immunology Receptors, Immunologic/immunology Receptors, Lipoprotein Receptors, Scavenger Scavenger Receptors, Class B Toll-Like Receptors

Chemicals

Drosophila Proteins Lectins, C-Type Macrophage-1 Antigen Mannose Receptor Mannose-Binding Lectins Membrane Glycoproteins Membrane Proteins Nerve Tissue Proteins Receptors, Cell Surface Receptors, Immunologic Receptors, Lipoprotein Receptors, Scavenger Scarb1 protein, mouse Scavenger Receptors, Class B Toll-Like Receptors dectin 1

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Gordon Siamon

Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, England. christine.holt@path.ox.ac.uk

Article Info

Journal

Cell

Abbr.

Cell

ISSN

0092-8674

DOI

10.1016/s0092-8674(02)01201-1

christine.holt@path.ox.ac.uk

Published

2002-12-27

Pages

927-30

Language

English

Region

United States

NLM ID

0413066

Subset

External Links

PubMed source DOI: 10.1016/s0092-8674(02)01201-1 View journal details

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Pattern recognition receptors: doubling up for the innate immune response.

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