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PMID: 16562864 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Natural products from plant-associated microorganisms: distribution, structural diversity, bioactivity, and implications of their occurrence.

Journal of natural products ·Vol. 69 ·No. 3 ·2006-03-00 ·Pages 509-26

Gunatilaka AA

Abstract

A growing body of evidence suggests that plant-associated microorganisms, especially endophytic and rhizosphere bacteria and fungi, represent a huge and largely untapped resource of natural products with chemical structures that have been optimized by evolution for biological and ecological relevance. A diverse array of bioactive small molecule natural products has been encountered in these microorganisms. The structures of over 230 metabolites isolated and characterized from over 70 plant-associated microbial strains during the past four years are presented with information on their hosts, culture conditions, and biological activities. Some significant biological and ecological implications of their occurrence are also reviewed.

MeSH Terms
Bacteria/chemistry Biological Products/chemistry,isolation & purification,pharmacology Fungi/chemistry Molecular Structure Plants/microbiology Symbiosis
Chemicals
Biological Products
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Gunatilaka A A Leslie
Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, University of Arizona, Tucson, 85706-6800, USA. leslieg@ag.arizona.edu
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Article Info
Journal
Journal of natural products
Abbr.
J Nat Prod
ISSN
0163-3864
DOI
10.1021/np058128n
Email
leslieg@ag.arizona.edu
Published
2006-03-00
Pages
509-26
Language
English
Region
United States
NLM ID
7906882
PMCID
PMC3362121
Subset
IM
Grants
NCI NIH HHS · R01 CA090265 · United States
NCI NIH HHS · R01 CA 90265 · United States
External Links
PubMed source DOI: 10.1021/np058128n PMC Full Text View journal details
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