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PMID: 1505860 Published · ppublish English Journal Article Review

Biological effects of the antibiotic brefeldin A (decumbin, cyanein, ascotoxin, synergisidin): a retrospective.

Folia microbiologica ·Vol. 37 ·No. 1 ·1992-00-00 ·Pages 3-11

Betina V

Abstract

Brefeldin A has been recently characterized to act as an inhibitor of intracellular protein export with profound effects on the structure and function of the Golgi apparatus in animal cells. Manifold activities of the antibiotic (under different names) published in the 1960's and 1970's are reviewed: effects on fungal growth and morphogenesis, inhibition of mitosis in plant cells, cytotoxicity, cancerostatic, antiviral and antinematodal activity and peculiar effects on DNA, RNA and protein synthesis in microbial and animal cells.

MeSH Terms
Animals Antibiotics, Antineoplastic/pharmacology Antifungal Agents/pharmacology Antinematodal Agents/pharmacology Antiviral Agents/pharmacology Brefeldin A Cyclopentanes/pharmacology Humans Plants/drug effects
Chemicals
Antibiotics, Antineoplastic Antifungal Agents Antinematodal Agents Antiviral Agents Cyclopentanes Brefeldin A
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Betina V
Department of Microbiology, Biochemistry and Biology, Faculty of Chemical Technology, Slovak Technical University, Bratislava.
References (48)
48 references, click to expand
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Article Info
Journal
Folia microbiologica
Abbr.
Folia Microbiol (Praha)
ISSN
0015-5632
DOI
10.1007/BF02814572
Published
1992-00-00
Pages
3-11
Language
English
Region
United States
NLM ID
0376757
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02814572 View journal details
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