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PMID: 16510164 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

Mouse hepatitis virus pathogenesis in the central nervous system is independent of IL-15 and natural killer cells.

Virology ·Vol. 350 ·No. 1 ·2006-06-20 ·Pages 206-15

Zuo J, Stohlman SA, Hoskin JB, Hinton DR, Atkinson R, Bergmann CC

Abstract

Infection by the neurotropic JHM strain of mouse hepatitis virus (JHMV) results in an acute encephalomyelitis associated with demyelination. T cells are critical in controlling viral replication, but also contribute to central nervous system (CNS) pathogenesis. To reveal a role for innate effectors in anti-viral immunity and neurological disease, JHMV pathogenesis was studied in mice deficient in interleukin-15 (IL-15-/-) and natural killer (NK) cells. Clinical disease, CNS inflammation and demyelination in infected IL-15-/- mice were similar to wild-type mice. Despite the absence of NK cells and suboptimal CD8+ T cell responses, IL-15-/- mice controlled JHMV replication as efficiently as wild-type mice. Similar kinetics of class I and class II upregulation on microglia further suggested no role of NK cells in regulating major histocompatibility complex (MHC) molecule expression on resident CNS cells. IL-15 and NK cells thus appear dispensable for anti-viral immunity and CNS pathogenesis during acute JHMV infection.

MeSH Terms
Animals CD8-Positive T-Lymphocytes/metabolism Central Nervous System/pathology,virology Coronavirus Infections/immunology,virology Encephalomyelitis/immunology,virology Gene Expression Regulation Interleukin-15/deficiency,genetics,metabolism Killer Cells, Natural/metabolism Major Histocompatibility Complex Mice Mice, Inbred C57BL Mice, Knockout Microglia/metabolism Murine hepatitis virus/pathogenicity Receptors, Antigen, T-Cell, gamma-delta/metabolism
Chemicals
Interleukin-15 Receptors, Antigen, T-Cell, gamma-delta
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Zuo Jun
Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA.
Stohlman Stephen A
Hoskin Jason B
Hinton David R
Atkinson Roscoe
Bergmann Cornelia C
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Article Info
Journal
Virology
Abbr.
Virology
ISSN
0042-6822
DOI
10.1016/j.virol.2006.01.027
Published
2006-06-20
Epub
2006-00-28
Pages
206-15
Language
English
Region
United States
NLM ID
0110674
PMCID
PMC7111870
Subset
IM
Grants
NINDS NIH HHS · P01 NS018146 · United States
NINDS NIH HHS · NS 18146 · United States
External Links
PubMed source DOI: 10.1016/j.virol.2006.01.027 PMC Full Text View journal details
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