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PMID: 11594450 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Chemokine expression and viral infection of the central nervous system: regulation of host defense and neuropathology.

Immunologic research ·Vol. 24 ·No. 2 ·2001-00-00 ·Pages 111-9

Liu MT, Lane TE

Abstract

An effective host response against viral infection of the central nervous system (CNS) is the principal factor dictating the outcome of infection. It is the responsibility of the immune response to contain and control viral replication. Paradoxically, it is the immune response that may also contribute to the development of neuropathology. We have used mouse hepatitis virus (MHV), apositive-strand RNA virus, infection of the CNS to understand the dynamic interaction between viral replication, protection, and pathology with an emphasis on understanding how chemokines participate in these interrelated processes. Herein, we demonstrate the complexity of the chemokine response to MHV infection of the CNS and the delicate balance that exists between host defense and development of disease.

MeSH Terms
Animals Central Nervous System Infections/immunology,mortality Coronavirus Infections/immunology,mortality Cytokines/biosynthesis Hepatitis, Viral, Animal/immunology,mortality Mice Murine hepatitis virus/immunology
Chemicals
Cytokines
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Liu M T
Department of Molecular Biology and Biochemistry University of California, Irvine 92697-3900, USA.
Lane T E
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34 references, click to expand
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Article Info
Journal
Immunologic research
Abbr.
Immunol Res
ISSN
0257-277X
DOI
10.1385/IR:24:2:111
Published
2001-00-00
Pages
111-9
Language
English
Region
United States
NLM ID
8611087
PMCID
PMC7090560
Subset
IM
Grants
NINDS NIH HHS · NS37336 · United States
NINDS NIH HHS · T32NS07444 · United States
External Links
PubMed source DOI: 10.1385/IR:24:2:111 PMC Full Text View journal details
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