Home LiteratureArticle Details
PMID: 16421734 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Nuclear transport is becoming crystal clear.

Chromosoma ·Vol. 115 ·No. 2 ·2006-04-00 ·Pages 98-109

Madrid AS, Weis K

Abstract

暂无摘要

MeSH Terms
Active Transport, Cell Nucleus/physiology Animals Crystallography, X-Ray Humans Nuclear Pore/physiology Nuclear Pore Complex Proteins/chemistry,physiology Protein Binding Protein Conformation Receptors, Cytoplasmic and Nuclear/chemistry,physiology ran GTP-Binding Protein/chemistry,physiology
Chemicals
Nuclear Pore Complex Proteins Receptors, Cytoplasmic and Nuclear ran GTP-Binding Protein
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Madrid Alexis S
Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720-3200, USA.
Weis Karsten
References (85)
85 references, click to expand
  1. Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor.
    Mol Cell. 2001 Sep;8(3):645-56 PMID: 11583626
  2. The adoption of a twisted structure of importin-beta is essential for the protein-protein interaction required for nuclear transport.
    J Mol Biol. 2000 Sep 8;302(1):251-64 PMID: 10964573
  3. HEAT repeats in the Huntington's disease protein.
    Nat Genet. 1995 Oct;11(2):115-6 PMID: 7550332
  4. Depletion of a single nucleoporin, Nup107, prevents the assembly of a subset of nucleoporins into the nuclear pore complex.
    Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):981-5 PMID: 12552102
  5. The 1.7 A crystal structure of the regulator of chromosome condensation (RCC1) reveals a seven-bladed propeller.
    Nature. 1998 Mar 5;392(6671):97-101 PMID: 9510255
  6. Importin-beta-like nuclear transport receptors.
    Genome Biol. 2001;2(6):REVIEWS3008 PMID: 11423015
  7. In vitro analysis of nuclear transport mediated by the C-terminal shuttle domain of Tap.
    J Biol Chem. 2001 Nov 9;276(45):42355-63 PMID: 11551912
  8. The N-terminal domain of Nup159 forms a beta-propeller that functions in mRNA export by tethering the helicase Dbp5 to the nuclear pore.
    Mol Cell. 2004 Dec 3;16(5):749-60 PMID: 15574330
  9. Structural basis for Nup2p function in cargo release and karyopherin recycling in nuclear import.
    EMBO J. 2003 Oct 15;22(20):5358-69 PMID: 14532109
  10. The kinetic mechanism of Ran--nucleotide exchange catalyzed by RCC1.
    Biochemistry. 1995 Oct 3;34(39):12543-52 PMID: 7548002
  11. The Saccharomyces cerevisiae nucleoporin Nup2p is a natively unfolded protein.
    J Biol Chem. 2002 Sep 6;277(36):33447-55 PMID: 12065587
  12. Transport into and out of the nucleus.
    Microbiol Mol Biol Rev. 2001 Dec;65(4):570-94, table of contents PMID: 11729264
  13. Architecture of CRM1/Exportin1 suggests how cooperativity is achieved during formation of a nuclear export complex.
    Mol Cell. 2004 Dec 3;16(5):761-75 PMID: 15574331
  14. Proteomic analysis of the mammalian nuclear pore complex.
    J Cell Biol. 2002 Sep 2;158(5):915-27 PMID: 12196509
  15. Nucleocytoplasmic transport: the soluble phase.
    Annu Rev Biochem. 1998;67:265-306 PMID: 9759490
  16. The RCC1 protein, a regulator for the onset of chromosome condensation locates in the nucleus and binds to DNA.
    J Cell Biol. 1989 Oct;109(4 Pt 1):1389-97 PMID: 2677018
  17. A structure/function analysis of Rat7p/Nup159p, an essential nucleoporin of Saccharomyces cerevisiae.
    J Cell Sci. 1997 Dec;110 ( Pt 23):2987-99 PMID: 9359887
  18. Disorder in the nuclear pore complex: the FG repeat regions of nucleoporins are natively unfolded.
    Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2450-5 PMID: 12604785
  19. Structural basis for the interaction between NTF2 and nucleoporin FxFG repeats.
    EMBO J. 2002 Jun 17;21(12):2843-53 PMID: 12065398
  20. NTF2 monomer-dimer equilibrium.
    J Mol Biol. 2001 Nov 30;314(3):465-77 PMID: 11846560
  21. RanGAP mediates GTP hydrolysis without an arginine finger.
    Nature. 2002 Feb 7;415(6872):662-6 PMID: 11832950
  22. Different binding domains for Ran-GTP and Ran-GDP/RanBP1 on nuclear import factor p97.
    J Biol Chem. 1997 Mar 7;272(10):6818-22 PMID: 9045717
  23. Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins.
    Science. 1990 Feb 23;247(4945):939-45 PMID: 2406906
  24. Structural basis of recognition of monopartite and bipartite nuclear localization sequences by mammalian importin-alpha.
    J Mol Biol. 2000 Apr 14;297(5):1183-94 PMID: 10764582
  25. The yeast RNA1 gene product necessary for RNA processing is located in the cytosol and apparently excluded from the nucleus.
    J Cell Biol. 1990 Aug;111(2):309-21 PMID: 2116418
  26. The structure of the Q69L mutant of GDP-Ran shows a major conformational change in the switch II loop that accounts for its failure to bind nuclear transport factor 2 (NTF2).
    J Mol Biol. 1998 Dec 18;284(5):1517-27 PMID: 9878368
  27. Removal of a single pore subcomplex results in vertebrate nuclei devoid of nuclear pores.
    Mol Cell. 2003 Apr;11(4):853-64 PMID: 12718872
  28. Nuclear import of sterol regulatory element-binding protein-2, a basic helix-loop-helix-leucine zipper (bHLH-Zip)-containing transcription factor, occurs through the direct interaction of importin beta with HLH-Zip.
    Mol Biol Cell. 1999 Jul;10(7):2221-33 PMID: 10397761
  29. The structure of the nuclear export receptor Cse1 in its cytosolic state reveals a closed conformation incompatible with cargo binding.
    Mol Cell. 2005 Apr 29;18(3):355-67 PMID: 15866177
  30. Structural basis for the assembly of a nuclear export complex.
    Nature. 2004 Dec 16;432(7019):872-7 PMID: 15602554
  31. An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells.
    J Cell Biol. 2001 Sep 17;154(6):1147-60 PMID: 11564755
  32. Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran.
    J Mol Biol. 1998 Apr 3;277(3):635-46 PMID: 9533885
  33. Crystallographic analysis of the specific yet versatile recognition of distinct nuclear localization signals by karyopherin alpha.
    Structure. 2000 Mar 15;8(3):329-38 PMID: 10745017
  34. GLFG and FxFG nucleoporins bind to overlapping sites on importin-beta.
    J Biol Chem. 2002 Dec 27;277(52):50597-606 PMID: 12372823
  35. Dbp5, a DEAD-box protein required for mRNA export, is recruited to the cytoplasmic fibrils of nuclear pore complex via a conserved interaction with CAN/Nup159p.
    EMBO J. 1999 Aug 2;18(15):4332-47 PMID: 10428971
  36. Prp20, the Saccharomyces cerevisiae homolog of the regulator of chromosome condensation, RCC1, interacts with double-stranded DNA through a multi-component complex containing GTP-binding proteins.
    J Cell Sci. 1993 Sep;106 ( Pt 1):287-98 PMID: 8270631
  37. The yeast nuclear pore complex: composition, architecture, and transport mechanism.
    J Cell Biol. 2000 Feb 21;148(4):635-51 PMID: 10684247
  38. Nuclear export of RNA.
    Biol Cell. 2004 Oct;96(8):639-55 PMID: 15519698
  39. Components of coated vesicles and nuclear pore complexes share a common molecular architecture.
    PLoS Biol. 2004 Dec;2(12):e380 PMID: 15523559
  40. Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha.
    Cell. 1998 Jul 24;94(2):193-204 PMID: 9695948
  41. Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: identification of a class of bipartite nuclear targeting sequence.
    Cell. 1991 Feb 8;64(3):615-23 PMID: 1991323
  42. Importin beta contains a COOH-terminal nucleoporin binding region important for nuclear transport.
    J Cell Biol. 2003 Aug 4;162(3):391-401 PMID: 12885761
  43. Structural basis for the specificity of bipartite nuclear localization sequence binding by importin-alpha.
    J Biol Chem. 2003 Jul 25;278(30):27981-7 PMID: 12695505
  44. The C-terminal extension of the small GTPase Ran is essential for defining the GDP-bound form.
    J Mol Biol. 2002 Apr 26;318(2):583-93 PMID: 12051861
  45. Modular self-assembly of a Y-shaped multiprotein complex from seven nucleoporins.
    EMBO J. 2002 Feb 1;21(3):387-97 PMID: 11823431
  46. Molecular basis for the recognition of a nonclassical nuclear localization signal by importin beta.
    Mol Cell. 2002 Dec;10(6):1345-53 PMID: 12504010
  47. Structural basis for the interaction between FxFG nucleoporin repeats and importin-beta in nuclear trafficking.
    Cell. 2000 Jul 7;102(1):99-108 PMID: 10929717
  48. Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1).
    Cell. 2001 Apr 20;105(2):245-55 PMID: 11336674
  49. Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp.
    Nature. 1999 May 20;399(6733):230-7 PMID: 10353245
  50. Protein folds propelled by diversity.
    Prog Biophys Mol Biol. 2001;76(1-2):103-30 PMID: 11389935
  51. Phospholipid scramblase 1 contains a nonclassical nuclear localization signal with unique binding site in importin alpha.
    J Biol Chem. 2005 Mar 18;280(11):10599-606 PMID: 15611084
  52. Two functionally distinct domains generated by in vivo cleavage of Nup145p: a novel biogenesis pathway for nucleoporins.
    EMBO J. 1997 Aug 15;16(16):5086-97 PMID: 9305650
  53. Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1.
    EMBO J. 1995 Feb 15;14(4):705-15 PMID: 7882974
  54. Three-dimensional architecture of the isolated yeast nuclear pore complex: functional and evolutionary implications.
    Mol Cell. 1998 Jan;1(2):223-34 PMID: 9659919
  55. The structure of importin-beta bound to SREBP-2: nuclear import of a transcription factor.
    Science. 2003 Nov 28;302(5650):1571-5 PMID: 14645851
  56. Dominant-negative mutants of importin-beta block multiple pathways of import and export through the nuclear pore complex.
    EMBO J. 1997 Mar 17;16(6):1153-63 PMID: 9135132
  57. Rat8p/Dbp5p is a shuttling transport factor that interacts with Rat7p/Nup159p and Gle1p and suppresses the mRNA export defect of xpo1-1 cells.
    EMBO J. 1999 Oct 15;18(20):5778-88 PMID: 10523319
  58. A gradient of affinity for the karyopherin Kap95p along the yeast nuclear pore complex.
    J Biol Chem. 2003 Oct 24;278(43):42699-709 PMID: 12917401
  59. Architecture of the Xenopus nuclear pore complex revealed by three-dimensional cryo-electron microscopy.
    J Cell Biol. 1993 Jul;122(1):1-19 PMID: 8314837
  60. Biophysical characterization of interactions involving importin-alpha during nuclear import.
    J Biol Chem. 2001 Sep 7;276(36):34189-98 PMID: 11448961
  61. A conserved biogenesis pathway for nucleoporins: proteolytic processing of a 186-kilodalton precursor generates Nup98 and the novel nucleoporin, Nup96.
    J Cell Biol. 1999 Mar 22;144(6):1097-112 PMID: 10087256
  62. SUMO-1 modification and its role in targeting the Ran GTPase-activating protein, RanGAP1, to the nuclear pore complex.
    J Cell Biol. 1998 Feb 9;140(3):499-509 PMID: 9456312
  63. Nuclear pore complex structure and dynamics revealed by cryoelectron tomography.
    Science. 2004 Nov 19;306(5700):1387-90 PMID: 15514115
  64. Structural basis for the interaction between the Tap/NXF1 UBA domain and FG nucleoporins at 1A resolution.
    J Mol Biol. 2003 Feb 21;326(3):849-58 PMID: 12581645
  65. The three-dimensional structure of the autoproteolytic, nuclear pore-targeting domain of the human nucleoporin Nup98.
    Mol Cell. 2002 Aug;10(2):347-58 PMID: 12191480
  66. A conditional allele of the novel repeat-containing yeast nucleoporin RAT7/NUP159 causes both rapid cessation of mRNA export and reversible clustering of nuclear pore complexes.
    J Cell Biol. 1995 May;129(4):939-55 PMID: 7744966
  67. The 1.6 angstroms resolution crystal structure of nuclear transport factor 2 (NTF2).
    J Mol Biol. 1996 Jul 19;260(3):422-31 PMID: 8757804
  68. Autoinhibition by an internal nuclear localization signal revealed by the crystal structure of mammalian importin alpha.
    Nat Struct Biol. 1999 Apr;6(4):388-97 PMID: 10201409
  69. Structural basis for nuclear import complex dissociation by RanGTP.
    Nature. 2005 Jun 2;435(7042):693-6 PMID: 15864302
  70. Crystal structure of the nuclear Ras-related protein Ran in its GDP-bound form.
    Nature. 1995 Mar 23;374(6520):378-81 PMID: 7885480
  71. The C terminus of the nuclear RAN/TC4 GTPase stabilizes the GDP-bound state and mediates interactions with RCC1, RAN-GAP, and HTF9A/RANBP1.
    J Biol Chem. 1995 Jun 16;270(24):14405-11 PMID: 7782302
  72. Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport.
    Nature. 1999 Mar 4;398(6722):39-46 PMID: 10078529
  73. Peering through the pore: nuclear pore complex structure, assembly, and function.
    Dev Cell. 2003 Jun;4(6):775-89 PMID: 12791264
  74. Structural basis for the high-affinity binding of nucleoporin Nup1p to the Saccharomyces cerevisiae importin-beta homologue, Kap95p.
    J Mol Biol. 2005 Jun 10;349(3):515-25 PMID: 15878174
  75. The conserved Nup107-160 complex is critical for nuclear pore complex assembly.
    Cell. 2003 Apr 18;113(2):195-206 PMID: 12705868
  76. Ran-unassisted nuclear migration of a 97-kD component of nuclear pore-targeting complex.
    J Cell Biol. 1997 Nov 17;139(4):841-9 PMID: 9362503
  77. Importin beta recognizes parathyroid hormone-related protein with high affinity and mediates its nuclear import in the absence of importin alpha.
    J Biol Chem. 1999 Mar 12;274(11):7391-8 PMID: 10066803
  78. Structural view of the Ran-Importin beta interaction at 2.3 A resolution.
    Cell. 1999 May 28;97(5):635-46 PMID: 10367892
  79. Structure of importin-beta bound to the IBB domain of importin-alpha.
    Nature. 1999 May 20;399(6733):221-9 PMID: 10353244
  80. A repeating amino acid motif shared by proteins with diverse cellular roles.
    Cell. 1994 Mar 11;76(5):789-91 PMID: 7907279
  81. Autoproteolysis in nucleoporin biogenesis.
    Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11370-5 PMID: 10500183
  82. Regulating access to the genome: nucleocytoplasmic transport throughout the cell cycle.
    Cell. 2003 Feb 21;112(4):441-51 PMID: 12600309
  83. Structural and functional analysis of Nup133 domains reveals modular building blocks of the nuclear pore complex.
    J Cell Biol. 2004 Nov 22;167(4):591-7 PMID: 15557116
  84. Isolation of the yeast nuclear pore complex.
    J Cell Biol. 1993 Nov;123(4):771-83 PMID: 8227139
  85. The crystal structure of rna1p: a new fold for a GTPase-activating protein.
    Mol Cell. 1999 Jun;3(6):781-91 PMID: 10394366
Article Info
Journal
Chromosoma
Abbr.
Chromosoma
ISSN
0009-5915
Published
2006-04-00
Epub
2006-00-19
Pages
98-109
Language
English
Region
Austria
NLM ID
2985138R
Subset
IM
Grants
NIGMS NIH HHS · GM58065 · United States
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com