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PMID: 16024794 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Analysis of a polycomb group protein defines regions that link repressive activity on nucleosomal templates to in vivo function.

Molecular and cellular biology ·Vol. 25 ·No. 15 ·2005-08-00 ·Pages 6578-91

King IF, Emmons RB, Francis NJ, Wild B, Müller J, Kingston RE, Wu CT

Abstract

Polycomb group (PcG) genes propagate patterns of transcriptional repression throughout development. The products of several such genes are part of Polycomb repressive complex 1 (PRC1), which inhibits chromatin remodeling and transcription in vitro. Genetic and biochemical studies suggest the product of the Posterior sex combs (Psc) gene plays a central role in both PcG-mediated gene repression in vivo and PRC1 activity in vitro. To dissect the relationship between the in vivo and in vitro activities of Psc, we identified the lesions associated with 11 genetically characterized Psc mutations and asked how the corresponding mutant proteins affect Psc activity on nucleosomal templates in vitro. Analysis of both single-mutant Psc proteins and recombinant complexes containing mutant protein revealed that Psc encodes at least two functions, complex formation and the inhibition of remodeling and transcription, which require different regions of the protein. There is an excellent correlation between the in vivo phenotypes of mutant Psc alleles and the structure and in vitro activities of the corresponding proteins, suggesting that the in vitro activities of PRC1 reflect essential functions of Psc in vivo.

MeSH Terms
Animals Binding Sites Chromatin Assembly and Disassembly/physiology DNA-Binding Proteins/genetics,metabolism Drosophila Proteins/genetics,metabolism Drosophila melanogaster/genetics,growth & development Mutation Nucleosomes/metabolism Phenotype Polycomb Repressive Complex 1 Protein Structure, Tertiary Repressor Proteins/metabolism,physiology Transcription, Genetic/physiology Wings, Animal/embryology
Chemicals
DNA-Binding Proteins Drosophila Proteins Nucleosomes Pc protein, Drosophila Repressor Proteins Psc protein, Drosophila Polycomb Repressive Complex 1
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
King Ian F G
Massachusetts General Hospital, Dept. of Molecular Biology, Welman 10, 50 Blossom St., Boston, MA 02114, USA.
Emmons Richard B
Francis Nicole J
Wild Brigitte
Müller Jürg
Kingston Robert E
Wu Chao-Ting
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
Published
2005-08-00
Pages
6578-91
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC1190323
Subset
IM
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