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PMID: 15595821 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Oligomerization of G protein-coupled receptors: past, present, and future.

Biochemistry ·Vol. 43 ·No. 50 ·2004-12-21 ·Pages 15643-56

Park PS, Filipek S, Wells JW, Palczewski K

Abstract

G protein-coupled receptor (GPCR)-mediated signal transduction has been studied for more than a century. Despite the intense focus on this class of proteins, a molecular understanding of what constitutes the functional form of the receptor is still uncertain. GPCRs have traditionally been conceptualized as monomeric proteins, and this view has changed little over the years until relatively recently. Recent biochemical and biophysical studies have challenged this traditional concept, and point instead to a mechanistic view of signal transduction wherein the receptor functions as an oligomer. Cooperative interactions within such an oligomeric array may be critical for the propagation of an external signal across the cell membrane and to the G protein, and may therefore underlie the mechanistic basis of signaling.

MeSH Terms
Animals Arrestin/chemistry,metabolism Biopolymers/metabolism Humans Protein Conformation Receptors, G-Protein-Coupled/metabolism Rhodopsin/chemistry,metabolism Signal Transduction Vision, Ocular
Chemicals
Arrestin Biopolymers Receptors, G-Protein-Coupled Rhodopsin
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Park Paul S-H
Department of Ophthalmology, University of Washington, Seattle, Washington 98195-6485, USA. ppark4@u.washington.edu
Filipek Slawomir
Wells James W
Palczewski Krzysztof
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Article Info
Journal
Biochemistry
Abbr.
Biochemistry
ISSN
0006-2960
DOI
10.1021/bi047907k
Email
ppark4@u.washington.edu
Published
2004-12-21
Pages
15643-56
Language
English
Region
United States
NLM ID
0370623
PMCID
PMC1752221
Subset
IM
Grants
NEI NIH HHS · R01 EY008061 · United States
NEI NIH HHS · EY08061 · United States
External Links
PubMed source DOI: 10.1021/bi047907k PMC Full Text View journal details
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