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PMID: 1533884 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Activation of the human immunodeficiency virus type 1 enhancer is not dependent on NFAT-1.

Journal of virology ·Vol. 66 ·No. 6 ·1992-06-00 ·Pages 3961-5

Markovitz DM, Hannibal MC, Smith MJ, Cossman R, Nabel GJ

Abstract

The function of a putative NFAT-1 site in the human immunodeficiency virus type 1 enhancer has been analyzed. Activation by the T-cell antigen receptor is minimal in Jurkat cells and is mediated by the kappa B sites. The putative NFAT-1 region is not required for the response to anti-CD3 or to mitogens in T-cell, B-cell, or monocyte/macrophage leukemia lines, nor is it a cis-acting negative regulatory element.

MeSH Terms
Antigens, Differentiation, T-Lymphocyte/immunology Base Sequence CD3 Complex DNA Mutational Analysis Gene Expression Regulation, Viral HIV Enhancer/genetics HIV-1/genetics Humans Leukocytes, Mononuclear/microbiology Macrophages/microbiology Mitogens/pharmacology Molecular Sequence Data NF-kappa B/metabolism Receptors, Antigen, T-Cell/immunology Transcription Factors/metabolism
Chemicals
Antigens, Differentiation, T-Lymphocyte CD3 Complex Mitogens NF-kappa B Receptors, Antigen, T-Cell Transcription Factors
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Markovitz D M
Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109-0650.
Hannibal M C
Smith M J
Cossman R
Nabel G J
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.66.6.3961-3965.1992
Published
1992-06-00
Pages
3961-5
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC241190
Subset
IM
Grants
NIAID NIH HHS · AI29179 · United States
NIAID NIH HHS · AI30924 · United States
NCI NIH HHS · CA01479 · United States
External Links
PubMed source DOI: 10.1128/JVI.66.6.3961-3965.1992 PMC Full Text View journal details
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